HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: TRIPC (Q14669)
E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)
Gene: TRIP12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1992
+	Hs
		1027302 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		HECW2_HUMAN (924-1991): 0: 626: 14.87
+	Hs
		800542 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		HECW2_HUMAN (924-1991): 0: 626: 14.87
+	Hs
		949903 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		HECW2_HUMAN (924-1991): 0: 626: 14.87
+	Hs
		1350506 CDYL_HUMAN (16-165): 6.53e-34: 127: 25.16		HECW2_HUMAN (924-1991): 0: 626: 14.87
+	Hs
		123333 CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52		HECW2_HUMAN (924-1991): 0: 626: 14.87
+	Hs
		134888 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		IMA3_HUMAN (365-866): 1.41e-154: 488: 13.33
+	Hs
		131397 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		IMA4_HUMAN (363-864): 7.19e-155: 489: 13.73
+	Hs
		134845 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		IMA3_HUMAN (365-866): 1.41e-154: 488: 13.33
+	Hs
		131416 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		IMA4_HUMAN (363-864): 7.19e-155: 489: 13.73
+	Hs
		134876 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		IMA3_HUMAN (365-866): 1.41e-154: 488: 13.33
+	At
		285377 Q058P7_ARATH (23-116): 1.44e-23: 98: 31.58		IMPA4_ARATH (347-906): 3.11e-164: 515: 15.99
+	At
		285382 LHP1_ARATH (23-116): 1.44e-23: 98: 31.58		IMPA4_ARATH (347-906): 3.11e-164: 515: 15.99
+	At
		1276955 LHP1_ARATH (23-116): 1.44e-23: 98: 31.58		IMPA1_ARATH (347-905): 5.44e-164: 514: 14.61
+	At
		984992 Q058P7_ARATH (23-116): 1.44e-23: 98: 31.58		IMPA1_ARATH (347-905): 5.44e-164: 514: 14.61
+	At
		97779 Q058P7_ARATH (23-116): 1.44e-23: 98: 31.58		IMPA2_ARATH (347-905): 3.96e-160: 504: 15.32
+	At
		97806 LHP1_ARATH (23-116): 1.44e-23: 98: 31.58		IMPA2_ARATH (347-905): 3.96e-160: 504: 15.32
+	At
		1276959 LHP1_ARATH (23-116): 1.44e-23: 98: 31.58		IMPA6_ARATH (347-906): 2.75e-153: 486: 13.88
+	At
		984993 Q058P7_ARATH (23-116): 1.44e-23: 98: 31.58		IMPA6_ARATH (347-906): 2.75e-153: 486: 13.88
+	Hs
		1335790 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		HECD1_HUMAN (437-1230): 6.18e-77: 287: 15.52
+	Hs
		1192126 CDYL2_HUMAN (28-125): 3.12e-25: 102: 28.43		HUWE1_HUMAN (1616-1992): 2.18e-25: 118: 28.72