HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: ZN462 (Q96JM2)
Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP)
Gene: ZNF462

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	27705803, 34079125, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 2506
+	Hs
		64140 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN729_HUMAN (439-1479): 0: 604: 11.72
+	Hs
		64135 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		ZN729_HUMAN (439-1479): 0: 604: 11.72
+	Hs
		1027217 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN184_HUMAN (575-1166): 9.89e-115: 385: 10.40
+	Hs
		800409 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		ZN569_HUMAN (606-1166): 3.09e-109: 367: 9.86
+	Hs
		800406 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		Z585B_HUMAN (582-1136): 1.18e-96: 333: 10.70
+	Hs
		970657 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZNF45_HUMAN (1657-1959): 2.74e-48: 187: 14.75
+	Hs
		1027143 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN420_HUMAN (2390-2505): 1.28e-37: 155: 17.95
+	Hs
		67424 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN850_HUMAN (470-948): 7.42e-35: 148: 13.16
+	Hs
		800350 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		ZNF45_HUMAN (1657-1959): 2.74e-48: 187: 14.75
+	Hs
		1027126 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN615_HUMAN (597-909): 9.26e-28: 124: 13.10
+	Hs
		1027294 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN226_HUMAN (470-889): 6.76e-27: 121: 13.83
+	Hs
		1027211 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN607_HUMAN (2390-2505): 7.76e-24: 111: 13.10
+	Hs
		1026995 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN267_HUMAN (1869-2348): 6.74e-14: 79.7: 22.73
+	Hs
		563302 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZNF16_HUMAN (2006-2436): 1.72e-12: 75.1: 23.25
+	Hs
		983755 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZNF91_HUMAN (439-838): 5.85e-12: 73.8: 12.41
+	Hs
		1027102 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN227_HUMAN (470-841): 5.38e-11: 70.4: 11.89
+	Hs
		1027345 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ZN337_HUMAN (2006-2436): 1.4e-10: 68.9: 24.84
+	Mm
		69863 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		ZN462_MOUSE (2330-2471): 2.84e-10: 68.4: 12.50
+	Hs
		64158 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		ZN726_HUMAN (1469-1820): 7e-15: 82.9: 17.27
+	Mm
		69859 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		ZN462_MOUSE (2330-2471): 2.84e-10: 68.4: 12.50