Protein: REEP2
Receptor expression-enhancing protein 2

Gene: REEP2
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q9BRK0

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005881 - cytoplasmic microtubule
GO:0005886 - plasma membrane
GO:0008017 - microtubule binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

941369

CAV3
Caveolin-3

2

5

High-throughput

0.628

High

1411239

REEP4
Receptor expression-enhancing protein 4

2

11

High-throughput

0.628

High

1411241

REEP1
Receptor expression-enhancing protein 1

2

11

High-throughput

0.628

High

1411243

KCIP2
A-type potassium channel modulatory protein KCNIP2

2

1

High-throughput

0.628

High

155499

C2C2L
Phospholipid transfer protein C2CD2L

2

1

High-throughput

0.606

High

325591

YIF1A
Protein YIF1A

2

3

High-throughput

0.606

High

539490

ITAM
Integrin alpha-M

2

1

High-throughput

0.606

High

549461

CD20
B-lymphocyte antigen CD20

2

1

High-throughput

0.606

High

1005410

CP4F2
Cytochrome P450 4F2

2

2

High-throughput

0.606

High

1238078

CP4FN
Ultra-long-chain fatty acid omega-hydroxylase

2

2

High-throughput

0.606

High

1322833

ORML3
ORM1-like protein 3

2

1

High-throughput

0.606

High

1411235

TM208
Transmembrane protein 208

2

3

High-throughput

0.606

High

1411247

PRAF1
Prenylated Rab acceptor protein 1

2

9

High-throughput

0.606

High

1411250

TMX2
Thioredoxin-related transmembrane protein 2

2

1

High-throughput

0.606

High

1286464

DSG4
Desmoglein-4

2

0

High-throughput

0.602

High

144478

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

934275

BI1
Bax inhibitor 1

2

0

High-throughput

0.580

High

1092084

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

2

0

High-throughput

0.580

High

1411246

NAT8
N-acetyltransferase 8

2

0

High-throughput

0.580

High

49692

T120B
Transmembrane protein 120B

2

2

High-throughput

0.553

High

339230

SFT2B
Vesicle transport protein SFT2B

2

2

High-throughput

0.553

High

885181

TTPA
Alpha-tocopherol transfer protein

2

5

High-throughput

0.553

High

1229449

TMM42
Transmembrane protein 42

2

2

High-throughput

0.553

High

1382923

S2546
Mitochondrial outer membrane protein SLC25A46

2

1

High-throughput

0.553

High

1388172

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

4

High-throughput

0.553

High

1411238

TMM60
Transmembrane protein 60

2

1

High-throughput

0.553

High

158304

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.536

High

971938

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.536

High

1049720

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1238312

REEP3
Receptor expression-enhancing protein 3

1

11

High-throughput

0.536

High

1244860

KCIP4
Kv channel-interacting protein 4

1

1

High-throughput

0.536

High

188085

MOT5
Monocarboxylate transporter 5

1

3

High-throughput

0.515

High

322055

ENDD1
Endonuclease domain-containing 1 protein

1

1

High-throughput

0.489

High

552868

TPR
Nucleoprotein TPR

1

1

High-throughput

0.489

High

617578

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

1

High-throughput

0.489

High

634601

LMNB1
Lamin-B1

1

2

High-throughput

0.489

High

730199

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.489

High

966812

1433G
14-3-3 protein gamma

1

20

High-throughput

0.489

High

990670

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.489

High

1393196

TM169
Transmembrane protein 169

1

1

High-throughput

0.489

High

48764

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.479

High

174070

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

275819

CAD16
Cadherin-16

1

2

High-throughput

0.479

High

530298

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.479

High

847664

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

895013

EMD
Emerin

1

2

High-throughput

0.479

High

1027156

REEP5
Receptor expression-enhancing protein 5

1

14

High-throughput

0.479

High

1058622

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

1326886

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.479

High

1333973

DHB11
Estradiol 17-beta-dehydrogenase 11

1

5

High-throughput

0.479

High

1383034

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1404175

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

1411237

DERL1
Derlin-1

1

3

High-throughput

0.479

High

1411240

RETR1
Reticulophagy regulator 1

1

7

Small-scale

0.479

High

1411248

AMFR
E3 ubiquitin-protein ligase AMFR

1

2

Small-scale

0.479

High

1372288

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.470

High

190253

MOT4
Monocarboxylate transporter 4

1

3

High-throughput

0.445

High

303276

S22A5
Organic cation/carnitine transporter 2

1

2

High-throughput

0.445

High

1207760

TMM31
Transmembrane protein 31

1

1

High-throughput

0.439

High

1238796

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

1252199

SYNE3
Nesprin-3

1

1

High-throughput

0.437

High

1392445

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

1411242

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1411244

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.437

High

1411245

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1227356

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

1337929

ZNT7
Zinc transporter 7

1

2

High-throughput

0.407

High

1359034

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

1381391

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

0

High-throughput

0.316

High

329165

RCBT2
RCC1 and BTB domain-containing protein 2

1

0

High-throughput

0.279

Low

1411236

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.279

Low

1411249

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025