Protein: MED1
Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)

Gene: MED1
Organism: Homo sapiens
Interactions: 174
UniProt ID: Q15648

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0000785 - chromatin
GO:0000902 - cell morphogenesis
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1076205

MED9
Mediator of RNA polymerase II transcription subunit 9

9

0

Small-scale

0.923

High

1076203

MED4
Mediator of RNA polymerase II transcription subunit 4

9

0

Small-scale

0.922

High

826280

CDK8
Cyclin-dependent kinase 8

17

10

Small-scale

0.765

High

740530

PPARG
Peroxisome proliferator-activated receptor gamma

18

20

Small-scale

0.760

High

48671

MED19
Mediator of RNA polymerase II transcription subunit 19

11

1

Small-scale

0.758

High

369678

ESR1
Estrogen receptor

9

20

Small-scale

0.757

High

1076182

MED12
Mediator of RNA polymerase II transcription subunit 12

10

16

Small-scale

0.755

High

500430

THA
Thyroid hormone receptor alpha

9

20

Small-scale

0.753

High

1076213

MED13
Mediator of RNA polymerase II transcription subunit 13

9

4

Small-scale

0.752

High

225382

MED14
Mediator of RNA polymerase II transcription subunit 14

8

10

Small-scale

0.751

High

509957

VDR
Vitamin D3 receptor

8

20

Small-scale

0.750

High

1076201

MED20
Mediator of RNA polymerase II transcription subunit 20

7

1

Small-scale

0.748

High

1076199

MED28
Mediator of RNA polymerase II transcription subunit 28

7

1

Small-scale

0.747

High

265328

MED24
Mediator of RNA polymerase II transcription subunit 24

8

1

Small-scale

0.747

High

1076189

MED15
Mediator of RNA polymerase II transcription subunit 15

7

7

Small-scale

0.746

High

1076198

CDK19
Cyclin-dependent kinase 19

7

9

High-throughput

0.746

High

1076172

MED25
Mediator of RNA polymerase II transcription subunit 25

8

3

Small-scale

0.744

High

624435

CCNC
Cyclin-C

7

3

Small-scale

0.741

High

313429

MED26
Mediator of RNA polymerase II transcription subunit 26

6

1

Small-scale

0.738

High

244487

BRD4
Bromodomain-containing protein 4

7

13

Small-scale

0.738

High

1076216

MED23
Mediator of RNA polymerase II transcription subunit 23

6

2

Small-scale

0.733

High

1076196

MED10
Mediator of RNA polymerase II transcription subunit 10

9

0

Small-scale

0.722

High

1076206

MED29
Mediator of RNA polymerase II transcription subunit 29

8

0

Small-scale

0.721

High

1076204

MED17
Mediator of RNA polymerase II transcription subunit 17

9

0

Small-scale

0.721

High

487975

RARA
Retinoic acid receptor alpha

5

20

Small-scale

0.717

High

206622

MED7
Mediator of RNA polymerase II transcription subunit 7

7

0

Small-scale

0.715

High

270504

MED6
Mediator of RNA polymerase II transcription subunit 6

7

0

Small-scale

0.714

High

1076219

MED16
Mediator of RNA polymerase II transcription subunit 16

7

0

Small-scale

0.714

High

1076171

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

5

4

Small-scale

0.712

High

1076197

MED18
Mediator of RNA polymerase II transcription subunit 18

6

0

Small-scale

0.709

High

1037053

MED21
Mediator of RNA polymerase II transcription subunit 21

6

0

Small-scale

0.705

High

587174

RXRA
Retinoic acid receptor RXR-alpha

5

20

Small-scale

0.705

High

1076166

MED27
Mediator of RNA polymerase II transcription subunit 27

6

0

Small-scale

0.702

High

1076185

MED8
Mediator of RNA polymerase II transcription subunit 8

6

0

Small-scale

0.702

High

1076186

MED30
Mediator of RNA polymerase II transcription subunit 30

6

0

Small-scale

0.702

High

1074701

MED22
Mediator of RNA polymerase II transcription subunit 22

6

0

Small-scale

0.699

High

1076180

ESR2
Estrogen receptor beta

4

20

Small-scale

0.693

High

1076220

MED31
Mediator of RNA polymerase II transcription subunit 31

5

0

Small-scale

0.691

High

1076208

MED11
Mediator of RNA polymerase II transcription subunit 11

5

0

Small-scale

0.688

High

377348

GCR
Glucocorticoid receptor

4

20

Small-scale

0.683

High

1076155

MED1
Mediator of RNA polymerase II transcription subunit 1

4

12

Small-scale

0.680

High

386799

P53
Cellular tumor antigen p53

3

6

Small-scale

0.678

High

1061325

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

20

High-throughput

0.667

High

1076175

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

3

16

High-throughput

0.667

High

624907

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

2

Small-scale

0.656

High

897522

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

1

Small-scale

0.656

High

1076212

DPOLL
DNA polymerase lambda

3

1

High-throughput

0.656

High

1076176

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.646

High

487468

ANDR
Androgen receptor

2

20

Small-scale

0.641

High

1076181

KAT2A
Histone acetyltransferase KAT2A

3

19

Small-scale

0.633

High

782552

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.629

High

583716

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

1

High-throughput

0.611

High

738970

SRBP1
Sterol regulatory element-binding protein 1

2

6

Small-scale

0.608

High

181419

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.602

High

874383

NR1H2
Oxysterols receptor LXR-beta

2

20

Small-scale

0.594

High

552815

RFA2
Replication protein A 32 kDa subunit

2

4

High-throughput

0.586

High

854421

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.585

High

913899

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.585

High

917328

H4
Histone H4

2

6

High-throughput

0.584

High

992421

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.584

High

1076183

FBXW7
F-box/WD repeat-containing protein 7

2

6

Small-scale

0.584

High

554454

GATA1
Erythroid transcription factor

1

9

Small-scale

0.581

High

374282

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

7

High-throughput

0.571

High

620353

GATA2
Endothelial transcription factor GATA-2

1

9

Small-scale

0.561

High

656406

PIT1
Pituitary-specific positive transcription factor 1

1

5

Small-scale

0.561

High

987772

GABPA
GA-binding protein alpha chain

1

12

Small-scale

0.561

High

1076210

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.561

High

1076165

TET2
Methylcytosine dioxygenase TET2

1

1

High-throughput

0.552

High

1076190

TGS1
Trimethylguanosine synthase

1

0

Small-scale

0.537

High

331298

CHK2
Serine/threonine-protein kinase Chk2

1

1

Small-scale

0.536

High

177687

BIRC5
Baculoviral IAP repeat-containing protein 5

1

2

High-throughput

0.536

High

266361

TAD2A
Transcriptional adapter 2-alpha

1

5

High-throughput

0.536

High

861767

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.536

High

962795

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.534

High

831357

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.527

High

1066973

BRD3
Bromodomain-containing protein 3

1

18

High-throughput

0.515

High

1076164

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

1076167

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

346874

MYC
Myc proto-oncogene protein

1

12

Small-scale

0.501

High

475806

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

646917

1433T
14-3-3 protein theta

1

20

Small-scale

0.501

High

647588

MK03
Mitogen-activated protein kinase 3

1

3

Small-scale

0.501

High

1025255

NR1H3
Oxysterols receptor LXR-alpha

1

20

Small-scale

0.501

High

1037944

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.501

High

1057761

NCOA6
Nuclear receptor coactivator 6

1

12

Small-scale

0.501

High

1076157

EZH2
Histone-lysine N-methyltransferase EZH2

1

16

Small-scale

0.501

High

1076222

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

Small-scale

0.501

High

1016066

SRBP2
Sterol regulatory element-binding protein 2

1

10

Small-scale

0.500

High

312716

CXB5
Gap junction beta-5 protein

1

1

High-throughput

0.494

High

1076184

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.493

High

1062526

EMC2
ER membrane protein complex subunit 2

1

9

High-throughput

0.489

High

1076188

SPAG5
Sperm-associated antigen 5

1

10

High-throughput

0.489

High

1076221

TRRAP
Transformation/transcription domain-associated protein

1

6

Small-scale

0.484

High

159216

CSKP
Peripheral plasma membrane protein CASK

1

8

High-throughput

0.481

High

856076

RBM5
RNA-binding protein 5

1

4

High-throughput

0.481

High

1076209

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.481

High

154191

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.480

High

148862

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.479

High

227549

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

304619

SCAF4
SR-related and CTD-associated factor 4

1

4

High-throughput

0.479

High

319849

HERC2
E3 ubiquitin-protein ligase HERC2

1

8

High-throughput

0.479

High

322685

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

13

High-throughput

0.479

High

324411

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

361575

APOA2
Apolipoprotein A-II

1

1

High-throughput

0.479

High

384900

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

455479

PARP1
Poly [ADP-ribose] polymerase 1

1

11

Small-scale

0.479

High

500488

THB
Thyroid hormone receptor beta

1

20

Small-scale

0.479

High

523782

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.479

High

583484

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.479

High

631439

BRD2
Bromodomain-containing protein 2

1

18

High-throughput

0.479

High

651297

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

668712

PML
Protein PML

1

11

High-throughput

0.479

High

676891

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.479

High

707643

H2B1B
Histone H2B type 1-B

1

15

High-throughput

0.479

High

720551

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

808638

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

818082

SOX2
Transcription factor SOX-2

1

12

Small-scale

0.479

High

841748

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.479

High

932181

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.479

High

934799

H31
Histone H3.1

1

20

High-throughput

0.479

High

944802

RED1
Double-stranded RNA-specific editase 1

1

11

High-throughput

0.479

High

952359

H33
Histone H3.3

1

20

High-throughput

0.479

High

959938

TF2B
Transcription initiation factor IIB

1

3

Small-scale

0.479

High

964340

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

971734

IRF8
Interferon regulatory factor 8

1

2

Small-scale

0.479

High

1018967

TP53B
TP53-binding protein 1

1

12

High-throughput

0.479

High

1027012

CBX3
Chromobox protein homolog 3

1

8

High-throughput

0.479

High

1031534

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.479

High

1032427

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.479

High

1076156

TRIP4
Activating signal cointegrator 1

1

1

High-throughput

0.479

High

1076158

DCAF6
DDB1- and CUL4-associated factor 6

1

9

High-throughput

0.479

High

1076160

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

16

High-throughput

0.479

High

1076161

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

11

High-throughput

0.479

High

1076173

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1076174

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1076177

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

1076178

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

1076179

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

15

Small-scale

0.479

High

1076192

T22D3
TSC22 domain family protein 3

1

1

Small-scale

0.479

High

1076193

TBX5
T-box transcription factor TBX5

1

6

High-throughput

0.479

High

1076194

EPAS1
Endothelial PAS domain-containing protein 1

1

6

Small-scale

0.479

High

1076207

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1076211

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1076214

HERC5
E3 ISG15--protein ligase HERC5

1

4

Small-scale

0.479

High

1076215

NUP50
Nuclear pore complex protein Nup50

1

1

High-throughput

0.479

High

1076217

HECD1
E3 ubiquitin-protein ligase HECTD1

1

9

High-throughput

0.479

High

266482

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

297909

ST65G
STAGA complex 65 subunit gamma

1

0

Small-scale

0.458

High

303266

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

534112

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.458

High

589869

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

738846

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

854306

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

921120

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1076170

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1076187

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1076200

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1076202

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

73029

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

8

High-throughput

0.445

High

91299

E5RFK5
Cyclin-C

1

2

High-throughput

0.445

High

728924

AHR
Aryl hydrocarbon receptor

1

7

Small-scale

0.445

High

1076159

Q5JQP4
DNA polymerase

1

1

High-throughput

0.445

High

1076218

TR150
Thyroid hormone receptor-associated protein 3

1

10

Small-scale

0.445

High

1015754

KIF1A
Kinesin-like protein KIF1A

1

4

High-throughput

0.439

High

1076195

AKAP9
A-kinase anchor protein 9

1

12

High-throughput

0.439

High

445161

IBP1
Insulin-like growth factor-binding protein 1

1

1

Small-scale

0.437

High

1076162

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.437

High

1076169

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1076191

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

329032

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

1076163

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1076168

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

473904

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024