HitPredict

Interactor 1: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	29513927, 32814053
Identification Methods	pull down, two hybrid array, two hybrid pooling approach, protein array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0031398 - positive regulation of protein ubiquitination GO:0035556 - intracellular signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 982 Hs			1 2527
+	Hs
		203231 SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		782847 CBLB_MOUSE (1-982): 0: 873: 95.12		CSK_MOUSE (1722-2140): 1.39e-102: 339: 21.20
+	Hs
		1027610 CBLB_HUMAN (1-982): 0: 877: 100.00		LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38
+	Hs
		610276 CBL_HUMAN (25-976): 0: 675: 47.10		CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74
+	Mm
		610555 CBL_MOUSE (25-976): 0: 674: 47.47		CSK_MOUSE (1722-2140): 1.39e-102: 339: 21.20
+	Hs
		1027632 CBLB_HUMAN (1-982): 0: 877: 100.00		MFHA1_HUMAN (838-1119): 1.5e-30: 134: 16.95
+	Mm
		101430 F8VPR5_MOUSE (420-869): 2.47e-09: 63.9: 9.29		CSK_MOUSE (1722-2140): 1.39e-102: 339: 21.20
+	Hs
		201365 CRBG2_HUMAN (419-932): 5.3e-10: 65.8: 11.09		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83