HitPredict

Interactor 1: ERCC8 (Q13216)
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)
Gene: ERCC8

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.975

The method score is based on:

Property Details
Experiments 29531219, 35271311, 37689310, 16949367, 26826127, 16751180, 17392787, 31970402, 34581821, 12732143, 22232169, 22902626
Identification Methods affinity chromatography technology, proximity labelling technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CPSF_A~WD40, MMS1_N~WD40
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006974 - DNA damage response
GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex
GO:0032991 - protein-containing complex
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 396
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024