HitPredict

Interactor 1: NMDE2 (Q13224)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
Gene: GRIN2B

Interactor 2: LIN7B (Q9HAP6)
Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
Gene: LIN7B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	10341223
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0098839 - postsynaptic density membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1484 Hs			1 207
+	Rn
		962670 NMDE2_RAT (1-1484): 0: 1829: 98.45		LIN7B_RAT (1-207): 2.14e-63: 196: 98.55
+	Hs
		158278 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Mm
		292486 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		LIN7C_MOUSE (1-196): 9.63e-58: 182: 84.69
+	Hs
		1028140 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG2_HUMAN (89-202): 4.85e-25: 103: 29.41
+	Hs
		942337 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG4_HUMAN (86-206): 6.05e-24: 100: 27.78
+	Hs
		1021485 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG1_HUMAN (59-180): 1.67e-23: 99.4: 29.92
+	Hs
		1028145 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG3_HUMAN (29-164): 2.29e-20: 90.3: 25.53
+	Rn
		962666 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG2_RAT (89-202): 4.22e-25: 104: 29.41
+	Rn
		962663 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG1_RAT (57-191): 8.24e-25: 103: 25.71
+	Mm
		963769 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG2_MOUSE (89-202): 4.39e-25: 104: 29.41
+	Rn
		677781 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG4_RAT (86-206): 5.61e-24: 100: 27.78
+	Mm
		963732 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG4_MOUSE (86-206): 2.01e-24: 102: 27.78
+	Mm
		963751 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG1_MOUSE (67-191): 1.67e-22: 96.7: 29.77
+	Rn
		962664 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG3_RAT (59-164): 2.5e-21: 93: 31.53
+	Mm
		936175 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG3_MOUSE (59-164): 2.62e-21: 93: 31.53
+	Mm
		963735 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		INADL_MOUSE (90-174): 1.1e-14: 73.9: 33.33
+	Mm
		723533 NMDE1_MOUSE (9-1484): 0: 1516: 52.79		DLG4_MOUSE (86-206): 2.01e-24: 102: 27.78
+	Rn
		677780 NMDE1_RAT (9-1484): 0: 1506: 52.59		DLG4_RAT (86-206): 5.61e-24: 100: 27.78
+	Mm
		723534 NMDE1_MOUSE (9-1484): 0: 1516: 52.79		INADL_MOUSE (90-174): 1.1e-14: 73.9: 33.33
+	Rn
		291500 NMDE1_RAT (9-1484): 0: 1506: 52.59		MAGI2_RAT (41-203): 1.97e-15: 76: 14.46