Protein: MDM4
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)

Gene: MDM4
Organism: Homo sapiens
Interactions: 108
UniProt ID: O15151

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003170 - heart valve development
GO:0003181 - atrioventricular valve morphogenesis
GO:0003203 - endocardial cushion morphogenesis
GO:0003281 - ventricular septum development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

179710

MDM2
E3 ubiquitin-protein ligase Mdm2

73

5

Small-scale

0.998

High

179650

MDM4
Protein Mdm4

5

5

Small-scale

0.922

High

179703

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

14

Small-scale

0.799

High

179692

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

14

Small-scale

0.778

High

179660

P53
Cellular tumor antigen p53

68

10

Small-scale

0.773

High

179666

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

4

Small-scale

0.768

High

179689

KC1A
Casein kinase I isoform alpha

13

5

Small-scale

0.761

High

179699

1433G
14-3-3 protein gamma

6

11

Small-scale

0.733

High

179651

P73
Tumor protein p73

6

10

Small-scale

0.732

High

179716

MKRN3
E3 ubiquitin-protein ligase makorin-3

4

1

High-throughput

0.706

High

179677

1433B
14-3-3 protein beta/alpha

5

11

Small-scale

0.706

High

179733

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

8

Small-scale

0.700

High

179705

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.691

High

179702

1433E
14-3-3 protein epsilon

5

0

Small-scale

0.686

High

179674

1433T
14-3-3 protein theta

4

11

Small-scale

0.672

High

179712

PPARD
Peroxisome proliferator-activated receptor delta

3

8

High-throughput

0.667

High

179725

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

0

High-throughput

0.663

High

179706

1433Z
14-3-3 protein zeta/delta

3

11

Small-scale

0.656

High

179735

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

3

0

Small-scale

0.652

High

179695

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

14

Small-scale

0.647

High

179748

CBLC
E3 ubiquitin-protein ligase CBL-C

1

1

High-throughput

0.647

High

179663

CDK1
Cyclin-dependent kinase 1

2

1

Small-scale

0.646

High

179662

RB
Retinoblastoma-associated protein

2

1

Small-scale

0.641

High

179678

1433S
14-3-3 protein sigma

3

11

Small-scale

0.640

High

179745

E2AK4
eIF-2-alpha kinase GCN2

2

3

High-throughput

0.628

High

179653

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

8

Small-scale

0.624

High

179682

CDN1A
Cyclin-dependent kinase inhibitor 1

2

2

Small-scale

0.624

High

179667

BCL2
Apoptosis regulator Bcl-2

2

1

Small-scale

0.611

High

179730

KC1AL
Casein kinase I isoform alpha-like

2

7

Small-scale

0.611

High

179698

WDR5
WD repeat-containing protein 5

2

2

High-throughput

0.606

High

179738

ZKSC3
Zinc finger protein with KRAB and SCAN domains 3

2

2

High-throughput

0.606

High

179659

S100B
Protein S100-B

2

9

Small-scale

0.602

High

179654

CCDB1
Cyclin-D1-binding protein 1

2

0

High-throughput

0.602

High

179726

ASGL1
Isoaspartyl peptidase/L-asparaginase

2

0

High-throughput

0.602

High

179713

1433F
14-3-3 protein eta

2

11

Small-scale

0.601

High

163013

CHK1
Serine/threonine-protein kinase Chk1

2

0

Small-scale

0.598

High

179685

CDN2A
Cyclin-dependent kinase inhibitor 2A

2

7

Small-scale

0.595

High

171048

VP26C
Vacuolar protein sorting-associated protein 26C

2

0

High-throughput

0.580

High

179683

NAA10
N-alpha-acetyltransferase 10

2

0

High-throughput

0.580

High

179744

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

179750

RN115
E3 ubiquitin-protein ligase RNF115

1

2

High-throughput

0.573

High

179714

UBE3A
Ubiquitin-protein ligase E3A

1

7

Small-scale

0.561

High

179719

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

Small-scale

0.561

High

179751

RA54B
DNA repair and recombination protein RAD54B

1

5

Small-scale

0.561

High

179723

Q3YBA8
14-3-3 tau splice variant

2

12

Small-scale

0.558

High

179728

TRI46
Tripartite motif-containing protein 46

1

6

High-throughput

0.541

High

179739

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.541

High

179668

TOP2A
DNA topoisomerase 2-alpha

1

0

Small-scale

0.537

High

179696

RL15
Large ribosomal subunit protein eL15

1

1

High-throughput

0.536

High

179711

E2F1
Transcription factor E2F1

1

1

Small-scale

0.527

High

179693

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.518

High

179656

CHK2
Serine/threonine-protein kinase Chk2

1

4

Small-scale

0.501

High

179661

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

179669

CDK4
Cyclin-dependent kinase 4

1

2

High-throughput

0.501

High

179673

S10A1
Protein S100-A1

1

9

Small-scale

0.501

High

179679

S10A5
Protein S100-A5

1

9

Small-scale

0.501

High

179680

MERL
Merlin

1

1

High-throughput

0.501

High

179686

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

6

High-throughput

0.501

High

179691

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

2

Small-scale

0.501

High

179709

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.501

High

179715

EP300
Histone acetyltransferase p300

1

4

Small-scale

0.501

High

179718

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

3

High-throughput

0.501

High

179720

SMAD4
Mothers against decapentaplegic homolog 4

1

1

Small-scale

0.501

High

179740

GLIS2
Zinc finger protein GLIS2

1

2

High-throughput

0.501

High

179742

P63
Tumor protein 63

1

10

Small-scale

0.501

High

179743

LATS2
Serine/threonine-protein kinase LATS2

1

6

High-throughput

0.501

High

179687

MAGA1
Melanoma-associated antigen 1

1

5

Small-scale

0.481

High

179734

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

3

High-throughput

0.481

High

179752

CAN7
Calpain-7

1

1

High-throughput

0.481

High

179670

HGF
Hepatocyte growth factor

1

0

High-throughput

0.480

High

179671

CD44
CD44 antigen

1

0

High-throughput

0.480

High

179717

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

Small-scale

0.480

High

179721

BECN1
Beclin-1

1

0

High-throughput

0.480

High

138592

IMA4
Importin subunit alpha-4

1

2

Small-scale

0.479

High

179652

NBN
Nibrin

1

2

Small-scale

0.479

High

179657

ABL1
Tyrosine-protein kinase ABL1

1

5

Small-scale

0.479

High

179658

ALBU
Albumin

1

1

Small-scale

0.479

High

179664

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

179665

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

179681

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

Small-scale

0.479

High

179684

MTOR
Serine/threonine-protein kinase mTOR

1

1

Small-scale

0.479

High

179688

MAGB1
Melanoma-associated antigen B1

1

5

Small-scale

0.479

High

179690

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.479

High

179694

RS20
Small ribosomal subunit protein uS10

1

1

Small-scale

0.479

High

179697

RL37
Large ribosomal subunit protein eL37

1

1

Small-scale

0.479

High

179700

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

Small-scale

0.479

High

179701

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

Small-scale

0.479

High

179704

RS15
Small ribosomal subunit protein uS19

1

1

Small-scale

0.479

High

179722

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

Small-scale

0.479

High

179731

COP1
E3 ubiquitin-protein ligase COP1

1

4

Small-scale

0.479

High

179732

RAD50
DNA repair protein RAD50

1

2

Small-scale

0.479

High

179736

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

Small-scale

0.479

High

179737

RING2
E3 ubiquitin-protein ligase RING2

1

6

Small-scale

0.479

High

179741

HIPK2
Homeodomain-interacting protein kinase 2

1

8

Small-scale

0.479

High

179749

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

6

Small-scale

0.479

High

179727

Q7Z479
Calpain-7

1

1

High-throughput

0.470

High

179729

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.458

High

179747

XPO7
Exportin-7

1

0

High-throughput

0.458

High

179672

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.457

High

179675

S10A2
Protein S100-A2

1

9

Small-scale

0.457

High

179676

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.457

High

3635

A0A0S2Z6X0
Zinc finger with KRAB and SCAN domains 4 isoform 3

1

3

High-throughput

0.457

High

179746

DAXX
Death domain-associated protein 6

1

2

Small-scale

0.445

High

179655

BY55
CD160 antigen

3

0

High-throughput

0.352

High

179724

SPT46
Spermatogenesis-associated protein 46

3

0

High-throughput

0.347

High

179707

HBB
Hemoglobin subunit beta

2

0

High-throughput

0.328

High

179708

F193A
Protein FAM193A

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025