Protein: E2F1
Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)

Gene: E2F1
Organism: Homo sapiens
Interactions: 235
UniProt ID: Q01094

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000228 - nuclear chromosome
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

442675

RB
Retinoblastoma-associated protein

72

20

Small-scale

0.998

High

1029083

TFDP1
Transcription factor Dp-1

23

20

Small-scale

0.991

High

1029084

TFDP2
Transcription factor Dp-2

9

20

Small-scale

0.972

High

704943

RBL1
Retinoblastoma-like protein 1

9

20

Small-scale

0.967

High

1029125

TOPB1
DNA topoisomerase 2-binding protein 1

8

4

Small-scale

0.757

High

143425

E2F3
Transcription factor E2F3

2

14

High-throughput

0.754

High

1029096

E2F4
Transcription factor E2F4

2

14

Small-scale

0.754

High

1029074

SKP2
S-phase kinase-associated protein 2

7

4

Small-scale

0.743

High

1029129

KAT2B
Histone acetyltransferase KAT2B

6

11

Small-scale

0.724

High

629104

CCNA2
Cyclin-A2

5

9

Small-scale

0.720

High

667785

CDK2
Cyclin-dependent kinase 2

5

15

Small-scale

0.717

High

464912

SP1
Transcription factor Sp1

4

9

Small-scale

0.705

High

1029068

EP300
Histone acetyltransferase p300

5

14

Small-scale

0.704

High

1029080

HDAC1
Histone deacetylase 1

5

6

Small-scale

0.702

High

1029128

KAT2A
Histone acetyltransferase KAT2A

5

15

Small-scale

0.699

High

766460

PHB1
Prohibitin 1

5

0

Small-scale

0.694

High

1029078

BIRC2
Baculoviral IAP repeat-containing protein 2

3

7

Small-scale

0.681

High

628751

TBP
TATA-box-binding protein

3

1

Small-scale

0.678

High

1029116

MCPH1
Microcephalin

3

1

Small-scale

0.678

High

842730

CDN2A
Cyclin-dependent kinase inhibitor 2A

3

1

Small-scale

0.664

High

1028152

MDM2
E3 ubiquitin-protein ligase Mdm2

3

1

Small-scale

0.664

High

1029181

TRRAP
Transformation/transcription domain-associated protein

3

4

Small-scale

0.650

High

1029133

SIR1
NAD-dependent protein deacetylase sirtuin-1

3

0

Small-scale

0.649

High

1029143

NECD
Necdin

2

6

Small-scale

0.649

High

138070

PSDE
26S proteasome non-ATPase regulatory subunit 14

3

3

Small-scale

0.640

High

666976

CCNE1
G1/S-specific cyclin-E1

3

11

Small-scale

0.640

High

1029066

RBL2
Retinoblastoma-like protein 2

3

20

Small-scale

0.633

High

799000

BRCA1
Breast cancer type 1 susceptibility protein

3

5

Small-scale

0.631

High

1007624

CCNA1
Cyclin-A1

2

9

Small-scale

0.629

High

1029185

NCOA3
Nuclear receptor coactivator 3

2

3

Small-scale

0.629

High

1029118

SETD7
Histone-lysine N-methyltransferase SETD7

3

0

Small-scale

0.627

High

138479

BIN1
Myc box-dependent-interacting protein 1

2

1

Small-scale

0.624

High

413640

P53
Cellular tumor antigen p53

2

3

Small-scale

0.624

High

1029172

FZR1
Fizzy-related protein homolog

2

4

Small-scale

0.624

High

830579

CCNF
Cyclin-F

2

16

Small-scale

0.620

High

905380

HCFC1
Host cell factor 1

2

3

Small-scale

0.620

High

282702

E2F6
Transcription factor E2F6

1

14

High-throughput

0.618

High

1029087

E2F2
Transcription factor E2F2

1

14

High-throughput

0.618

High

1029093

E2F5
Transcription factor E2F5

1

14

High-throughput

0.618

High

487200

PARP1
Poly [ADP-ribose] polymerase 1

2

5

Small-scale

0.611

High

1029065

RING1
E3 ubiquitin-protein ligase RING1

2

17

Small-scale

0.611

High

744651

TF2H1
General transcription factor IIH subunit 1

2

0

Small-scale

0.603

High

246538

KDM1A
Lysine-specific histone demethylase 1A

2

7

Small-scale

0.602

High

1025681

PURA
Transcriptional activator protein Pur-alpha

2

1

Small-scale

0.602

High

1022694

XIAP
E3 ubiquitin-protein ligase XIAP

2

6

Small-scale

0.601

High

1029138

LMBL3
Lethal(3)malignant brain tumor-like protein 3

2

13

Small-scale

0.601

High

873942

NRIP1
Nuclear receptor-interacting protein 1

2

0

Small-scale

0.598

High

1029127

CBP
CREB-binding protein

2

13

Small-scale

0.594

High

626183

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

8

Small-scale

0.589

High

848856

MAGAB
Melanoma-associated antigen 11

2

6

Small-scale

0.584

High

897240

CDK7
Cyclin-dependent kinase 7

2

14

Small-scale

0.584

High

1029069

CDC20
Cell division cycle protein 20 homolog

2

4

Small-scale

0.584

High

1029073

TIF1B
Transcription intermediary factor 1-beta

2

8

Small-scale

0.584

High

1029095

EZH2
Histone-lysine N-methyltransferase EZH2

2

6

Small-scale

0.584

High

1029126

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

3

Small-scale

0.584

High

1029175

PA2G4
Proliferation-associated protein 2G4

2

3

Small-scale

0.584

High

838060

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

High-throughput

0.578

High

1029122

DDB2
DNA damage-binding protein 2

1

3

Small-scale

0.578

High

1029182

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.578

High

1029183

NCOR2
Nuclear receptor corepressor 2

1

5

High-throughput

0.578

High

690913

1433T
14-3-3 protein theta

1

6

Small-scale

0.573

High

1029064

GABP1
GA-binding protein subunit beta-1

1

1

Small-scale

0.573

High

1029091

NCOA6
Nuclear receptor coactivator 6

1

10

Small-scale

0.573

High

1029090

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

Small-scale

0.573

High

674137

BRD2
Bromodomain-containing protein 2

2

13

Small-scale

0.571

High

520558

RARA
Retinoic acid receptor alpha

1

4

Small-scale

0.561

High

1029057

SP2
Transcription factor Sp2

1

10

Small-scale

0.561

High

1029058

SP4
Transcription factor Sp4

1

9

Small-scale

0.561

High

1029059

SP3
Transcription factor Sp3

1

9

Small-scale

0.561

High

1029062

UBE3A
Ubiquitin-protein ligase E3A

1

2

Small-scale

0.561

High

1029070

TP53B
TP53-binding protein 1

1

3

Small-scale

0.561

High

1029076

MTA1
Metastasis-associated protein MTA1

1

3

Small-scale

0.561

High

1029081

CUL1
Cullin-1

1

2

Small-scale

0.561

High

1029082

CUL2
Cullin-2

1

2

Small-scale

0.561

High

1029094

CEBPE
CCAAT/enhancer-binding protein epsilon

1

6

Small-scale

0.561

High

1029105

ATAD2
ATPase family AAA domain-containing protein 2

1

3

Small-scale

0.561

High

1029139

NSE3
Non-structural maintenance of chromosomes element 3 homolog

1

6

Small-scale

0.561

High

1029145

ARI3A
AT-rich interactive domain-containing protein 3A

1

9

Small-scale

0.561

High

1029177

KDM2A
Lysine-specific demethylase 2A

1

9

Small-scale

0.561

High

262061

NBN
Nibrin

2

0

Small-scale

0.559

High

1029168

APC5
Anaphase-promoting complex subunit 5

2

0

Small-scale

0.559

High

162544

ANM5
Protein arginine N-methyltransferase 5

1

4

Small-scale

0.554

High

1029086

BTG3
Protein BTG3

1

0

Small-scale

0.554

High

822614

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.537

High

1029147

RN126
E3 ubiquitin-protein ligase RNF126

1

0

Small-scale

0.537

High

1029109

CARM1
Histone-arginine methyltransferase CARM1

1

4

Small-scale

0.536

High

1029174

PHF8
Histone lysine demethylase PHF8

1

2

Small-scale

0.536

High

179711

MDM4
Protein Mdm4

1

1

Small-scale

0.527

High

334342

TRI16
Tripartite motif-containing protein 16

1

2

Small-scale

0.515

High

887413

CEBPD
CCAAT/enhancer-binding protein delta

1

6

Small-scale

0.515

High

938093

ANM2
Protein arginine N-methyltransferase 2

1

4

Small-scale

0.515

High

1029077

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

Small-scale

0.515

High

1029137

DCAF5
DDB1- and CUL4-associated factor 5

1

4

Small-scale

0.515

High

421938

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

1029164

STML1
Stomatin-like protein 1

1

1

High-throughput

0.512

High

443311

CDK1
Cyclin-dependent kinase 1

1

14

Small-scale

0.501

High

622795

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

5

Small-scale

0.501

High

1029075

ATM
Serine-protein kinase ATM

1

4

Small-scale

0.501

High

1029079

ATR
Serine/threonine-protein kinase ATR

1

4

Small-scale

0.501

High

1029176

FBW1A
F-box/WD repeat-containing protein 1A

1

6

Small-scale

0.501

High

1029114

ARF
Tumor suppressor ARF

1

0

Small-scale

0.493

High

1029136

PAWR
PRKC apoptosis WT1 regulator protein

1

0

Small-scale

0.493

High

519486

MYBB
Myb-related protein B

1

6

Small-scale

0.481

High

898223

R144A
E3 ubiquitin-protein ligase RNF144A

1

3

Small-scale

0.481

High

1029056

SPIB
Transcription factor Spi-B

1

8

Small-scale

0.481

High

1029085

FHL2
Four and a half LIM domains protein 2

1

5

Small-scale

0.481

High

1029110

MGAP
MAX gene-associated protein

1

4

Small-scale

0.481

High

1029142

TEAD3
Transcriptional enhancer factor TEF-5

1

2

Small-scale

0.481

High

1029150

IPKB
cAMP-dependent protein kinase inhibitor beta

1

1

Small-scale

0.481

High

1029071

PRDM2
PR domain zinc finger protein 2

1

0

Small-scale

0.480

High

175875

SET1A
Histone-lysine N-methyltransferase SETD1A

1

10

Small-scale

0.479

High

279145

ULK1
Serine/threonine-protein kinase ULK1

1

3

Small-scale

0.479

High

283460

TAD2A
Transcriptional adapter 2-alpha

1

9

High-throughput

0.479

High

334545

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

1

Small-scale

0.479

High

371786

MYC
Myc proto-oncogene protein

1

11

Small-scale

0.479

High

395928

ESR1
Estrogen receptor

1

6

Small-scale

0.479

High

519952

ANDR
Androgen receptor

1

5

Small-scale

0.479

High

718543

CDC27
Cell division cycle protein 27 homolog

1

1

Small-scale

0.479

High

777265

AHR
Aryl hydrocarbon receptor

1

3

Small-scale

0.479

High

789473

PPARG
Peroxisome proliferator-activated receptor gamma

1

5

Small-scale

0.479

High

881509

CDK8
Cyclin-dependent kinase 8

1

14

Small-scale

0.479

High

886761

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

Small-scale

0.479

High

891460

GSK3B
Glycogen synthase kinase-3 beta

1

10

Small-scale

0.479

High

892750

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

4

Small-scale

0.479

High

903131

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

7

Small-scale

0.479

High

907382

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

Small-scale

0.479

High

996911

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.479

High

1029060

TF65
Transcription factor p65

1

4

Small-scale

0.479

High

1029061

UBXN1
UBX domain-containing protein 1

1

2

High-throughput

0.479

High

1029067

RBBP4
Histone-binding protein RBBP4

1

6

Small-scale

0.479

High

1029088

BECN1
Beclin-1

1

1

Small-scale

0.479

High

1029092

SUZ12
Polycomb protein SUZ12

1

2

Small-scale

0.479

High

1029097

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.479

High

1029100

IF16
Gamma-interferon-inducible protein 16

1

1

Small-scale

0.479

High

1029103

ARI4B
AT-rich interactive domain-containing protein 4B

1

10

High-throughput

0.479

High

1029106

CWC27
Spliceosome-associated protein CWC27 homolog

1

3

High-throughput

0.479

High

1029107

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

10

High-throughput

0.479

High

1029113

DRAM1
DNA damage-regulated autophagy modulator protein 1

1

1

Small-scale

0.479

High

1029124

SNX19
Sorting nexin-19

1

1

Small-scale

0.479

High

1029130

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.479

High

1029140

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

6

Small-scale

0.479

High

1029141

PHF12
PHD finger protein 12

1

4

High-throughput

0.479

High

1029144

KLF6
Krueppel-like factor 6

1

12

Small-scale

0.479

High

1029149

PCGF6
Polycomb group RING finger protein 6

1

15

High-throughput

0.479

High

1029151

EPC1
Enhancer of polycomb homolog 1

1

1

High-throughput

0.479

High

1029152

CSR2B
Cysteine-rich protein 2-binding protein

1

2

High-throughput

0.479

High

1029161

APC11
Anaphase-promoting complex subunit 11

1

1

Small-scale

0.479

High

1029165

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

3

Small-scale

0.479

High

1029166

LEF1
Lymphoid enhancer-binding factor 1

1

5

Small-scale

0.479

High

1029167

APC7
Anaphase-promoting complex subunit 7

1

1

Small-scale

0.479

High

1029171

YETS2
YEATS domain-containing protein 2

1

4

High-throughput

0.479

High

1029180

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

10

Small-scale

0.479

High

341027

DIRA3
GTP-binding protein Di-Ras3

1

5

Small-scale

0.470

High

420278

IGF1
Insulin-like growth factor 1

1

0

Small-scale

0.460

High

1029153

BRMS1
Breast cancer metastasis-suppressor 1

1

0

Small-scale

0.460

High

219155

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.458

High

284822

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.458

High

294627

ZMY10
Zinc finger MYND domain-containing protein 10

1

0

Small-scale

0.458

High

370633

FOS
Protein c-Fos

1

0

Small-scale

0.458

High

507850

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

556019

CADH1
Cadherin-1

1

0

Small-scale

0.458

High

608550

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

611720

BMP7
Bone morphogenetic protein 7

1

0

Small-scale

0.458

High

771873

CBS
Cystathionine beta-synthase

1

0

Small-scale

0.458

High

775411

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.458

High

876829

KC1A
Casein kinase I isoform alpha

1

0

Small-scale

0.458

High

880286

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.458

High

951620

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

1029063

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

0

Small-scale

0.458

High

1029098

PDK4
[Pyruvate dehydrogenase

1

0

Small-scale

0.458

High

1029112

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.458

High

1029117

HASP
Serine/threonine-protein kinase haspin

1

0

Small-scale

0.458

High

1029119

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1029120

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1029134

SGF29
SAGA-associated factor 29

1

0

High-throughput

0.458

High

1029156

NGRN
Neugrin

1

0

High-throughput

0.458

High

1029159

RASF1
Ras association domain-containing protein 1

1

0

Small-scale

0.458

High

1029160

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

1029173

TIM
Protein timeless homolog

1

0

Small-scale

0.458

High

1029178

NOP16
Nucleolar protein 16

1

0

High-throughput

0.458

High

728178

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

High-throughput

0.457

High

131160

CLIC1
Chloride intracellular channel protein 1

1

1

High-throughput

0.445

High

135174

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

2

High-throughput

0.445

High

162819

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

2

High-throughput

0.445

High

175650

SR140
U2 snRNP-associated SURP motif-containing protein

1

1

High-throughput

0.445

High

259807

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.445

High

290306

KS6A4
Ribosomal protein S6 kinase alpha-4

1

3

High-throughput

0.445

High

300139

GLRX3
Glutaredoxin-3

1

2

High-throughput

0.445

High

690477

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.445

High

813454

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

2

High-throughput

0.445

High

827746

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.445

High

858892

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.445

High

859574

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.445

High

903320

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

8

High-throughput

0.445

High

1029104

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.445

High

1029111

SUGP1
SURP and G-patch domain-containing protein 1

1

1

High-throughput

0.445

High

1029131

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.445

High

1029132

MGN2
Protein mago nashi homolog 2

1

1

High-throughput

0.445

High

1029135

SPF45
Splicing factor 45

1

3

High-throughput

0.445

High

1029146

FERM1
Fermitin family homolog 1

1

1

High-throughput

0.445

High

1029169

RALY
RNA-binding protein Raly

1

1

High-throughput

0.445

High

1029170

MKLN1
Muskelin

1

4

High-throughput

0.445

High

1029184

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

2

High-throughput

0.445

High

464439

TSP1
Thrombospondin-1

1

1

Small-scale

0.437

High

1029121

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.437

High

344921

WIZ
Protein Wiz

1

0

High-throughput

0.426

High

460501

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

High-throughput

0.426

High

562588

RINI
Ribonuclease inhibitor

1

0

High-throughput

0.426

High

725777

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.426

High

834427

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

851873

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.426

High

913470

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.426

High

961260

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.426

High

969188

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.426

High

1029072

RED
Protein Red

1

0

High-throughput

0.426

High

1029089

PLSI
Plastin-1

1

0

High-throughput

0.426

High

1029099

FSCN1
Fascin

1

0

High-throughput

0.426

High

1029101

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.426

High

1029123

H1X
Histone H1.10

1

0

High-throughput

0.426

High

1029148

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

0

High-throughput

0.426

High

1029155

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

0

High-throughput

0.426

High

1029162

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.426

High

1029179

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.426

High

1013983

RL36A
Large ribosomal subunit protein eL42

1

1

High-throughput

0.407

High

1029158

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

Small-scale

0.391

High

1029157

NPDC1
Neural proliferation differentiation and control protein 1

1

0

Small-scale

0.275

Low

139375

NCHL1
Neural cell adhesion molecule L1-like protein

1

0

High-throughput

0.249

Low

1029108

LAP4B
Lysosomal-associated transmembrane protein 4B

1

0

Small-scale

0.249

Low

1029163

ATS9
A disintegrin and metalloproteinase with thrombospondin motifs 9

1

0

Small-scale

0.249

Low

446406

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.232

Low

875854

GSHB
Glutathione synthetase

1

0

High-throughput

0.232

Low

877319

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.232

Low

1029102

D19L1
Protein C-mannosyl-transferase DPY19L1

1

0

High-throughput

0.232

Low

1029115

GPT11
G patch domain-containing protein 11

1

0

High-throughput

0.232

Low

1029154

RM47
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025