HitPredict

Interactor 1: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Interactor 2: JIP3 (Q9UPT6)
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Gene: MAPK8IP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10523642
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1512 Hs			1 1336
+	Mm
		861669 M3K1_MOUSE (1-1512): 0: 1911: 88.47		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Hs
		725153 M3K1_HUMAN (1-1512): 0: 1994: 100.00		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		1305603 M3K5_HUMAN (1249-1503): 1.95e-40: 166: 37.31		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Mm
		192203 M3K5_MOUSE (1249-1503): 1.68e-40: 166: 37.31		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Hs
		229727 M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Mm
		192189 M3K5_MOUSE (1249-1503): 1.68e-40: 166: 37.31		JIP4_MOUSE (6-1336): 0: 681: 54.61
+	Hs
		1082021 PKN2_HUMAN (785-1509): 6.77e-150: 485: 16.27		CC136_HUMAN (23-567): 3.52e-09: 63.5: 12.89
+	Dm
		397193 KPC1_DROME (963-1509): 1.35e-126: 412: 17.24		MYSN_DROME (82-656): 4.06e-20: 99.7: 11.63
+	Hs
		551713 KPCD1_HUMAN (852-1510): 2.29e-124: 413: 16.89		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		566469 KPCA_HUMAN (963-1509): 9.28e-133: 428: 18.93		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56
+	Hs
		1081965 PKN1_HUMAN (777-1512): 3.49e-122: 407: 14.62		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56
+	Hs
		1081960 PKN1_HUMAN (777-1512): 3.49e-122: 407: 14.62		CC136_HUMAN (23-567): 3.52e-09: 63.5: 12.89
+	Hs
		625530 CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85		MY18A_HUMAN (189-793): 1.74e-25: 117: 9.00
+	Hs
		625177 CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		625176 CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		551610 CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		725229 M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		724983 M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		149212 M3K5_HUMAN (1249-1503): 1.95e-40: 166: 37.31		CTRO_HUMAN (1-425): 1.46e-17: 91.4: 9.17
+	Hs
		111262 J3KNB8_HUMAN (1242-1505): 2.6e-38: 159: 33.21		KI21A_HUMAN (40-567): 1.66e-13: 78: 9.65