Protein: BI2L1
BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)

Gene: BI2L1, BAIAP2L1
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q9UHR4

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460059

BAIP2
BAR/IMD domain-containing adapter protein 2

7

16

High-throughput

0.968

High

72939

ESPN
Espin

1

5

High-throughput

0.691

High

856972

BAG6
Large proline-rich protein BAG6

1

8

High-throughput

0.691

High

1417983

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

10

Small-scale

0.647

High

1460058

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

9

Small-scale

0.647

High

1460062

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

13

Small-scale

0.647

High

1090381

EPS8
Epidermal growth factor receptor kinase substrate 8

2

11

Small-scale

0.646

High

243222

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.618

High

363986

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

463824

LYN
Tyrosine-protein kinase Lyn

1

7

High-throughput

0.618

High

541744

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

640319

EPHA1
Ephrin type-A receptor 1

1

18

High-throughput

0.618

High

648718

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

710552

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

710913

EPHB2
Ephrin type-B receptor 2

1

18

High-throughput

0.618

High

932150

EPHA4
Ephrin type-A receptor 4

1

19

High-throughput

0.618

High

1034199

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.618

High

1034371

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

1147458

EPHA7
Ephrin type-A receptor 7

1

18

High-throughput

0.618

High

1157104

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

953164

ACTB
Actin, cytoplasmic 1

2

14

High-throughput

0.611

High

1180077

PWP3A
PWWP domain-containing DNA repair factor 3A

2

0

High-throughput

0.602

High

1251697

T184A
Transmembrane protein 184A

2

0

High-throughput

0.602

High

1446827

GPC5C
G-protein coupled receptor family C group 5 member C

2

0

High-throughput

0.602

High

260581

BRD4
Bromodomain-containing protein 4

2

2

Small-scale

0.584

High

376065

RASK
GTPase KRas

2

17

High-throughput

0.584

High

540738

LAMP1
Lysosome-associated membrane glycoprotein 1

2

4

High-throughput

0.584

High

891862

GSK3B
Glycogen synthase kinase-3 beta

2

5

High-throughput

0.584

High

978381

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

70529

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

228521

LANC1
Glutathione S-transferase LANCL1

2

0

High-throughput

0.580

High

347980

BAG3
BAG family molecular chaperone regulator 3

2

0

High-throughput

0.580

High

1028438

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.578

High

1326785

MALD2
MARVEL domain-containing protein 2

2

2

High-throughput

0.574

High

414792

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

138332

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

High-throughput

0.536

High

273590

DJC13
DnaJ homolog subfamily C member 13

1

5

High-throughput

0.536

High

281113

TACC1
Transforming acidic coiled-coil-containing protein 1

1

6

High-throughput

0.536

High

730333

1433B
14-3-3 protein beta/alpha

1

18

High-throughput

0.536

High

854372

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

930814

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.536

High

972104

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.536

High

990842

1433Z
14-3-3 protein zeta/delta

1

18

High-throughput

0.536

High

993371

ACTG
Actin, cytoplasmic 2

1

13

High-throughput

0.536

High

1036700

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

11

High-throughput

0.536

High

1399535

IP6K3
Inositol hexakisphosphate kinase 3

1

1

High-throughput

0.536

High

1460060

NTNG1
Netrin-G1

1

1

High-throughput

0.536

High

1460061

KIF3A
Kinesin-like protein KIF3A

1

6

High-throughput

0.536

High

1460064

KC1G3
Casein kinase I isoform gamma-3

1

6

High-throughput

0.536

High

1027829

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

2

High-throughput

0.515

High

225718

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

329993

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.513

High

1161808

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.513

High

1369509

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1389123

KBP
KIF-binding protein

1

0

High-throughput

0.513

High

1405067

SORT
Sortilin

1

0

High-throughput

0.513

High

842670

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.501

High

861827

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

8

High-throughput

0.501

High

869525

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

7

Small-scale

0.501

High

1389519

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.489

High

1454194

NHSL3
NHS-like protein 3

1

12

High-throughput

0.489

High

126861

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

164465

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

189913

STX7
Syntaxin-7

1

6

High-throughput

0.479

High

374264

RASN
GTPase NRas

1

17

High-throughput

0.479

High

374993

RASH
GTPase HRas

1

13

High-throughput

0.479

High

459790

PROF1
Profilin-1

1

3

High-throughput

0.479

High

466514

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

556403

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

560549

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

562470

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.479

High

581361

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

583011

EZRI
Ezrin

1

3

High-throughput

0.479

High

601485

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

643125

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

664824

CCND1
G1/S-specific cyclin-D1

1

1

High-throughput

0.479

High

693122

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

714498

PML
Protein PML

1

5

High-throughput

0.479

High

715833

MARCS
Myristoylated alanine-rich C-kinase substrate

1

11

High-throughput

0.479

High

728468

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.479

High

845846

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

891346

GSK3A
Glycogen synthase kinase-3 alpha

1

5

High-throughput

0.479

High

896660

VASP
Vasodilator-stimulated phosphoprotein

1

5

High-throughput

0.479

High

928578

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.479

High

935253

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

941853

ARL4C
ADP-ribosylation factor-like protein 4C

1

7

High-throughput

0.479

High

942944

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

16

High-throughput

0.479

High

953744

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955727

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

962610

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962852

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

975298

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

976639

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.479

High

986798

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

988802

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

995878

ACTC
Actin, alpha cardiac muscle 1

1

11

High-throughput

0.479

High

1015886

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1031585

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

1045880

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1049884

1433F
14-3-3 protein eta

1

18

High-throughput

0.479

High

1138727

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1145157

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.479

High

1150016

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.479

High

1151920

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1156616

CCDC6
Coiled-coil domain-containing protein 6

1

4

High-throughput

0.479

High

1227649

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

1350493

BICD2
Protein bicaudal D homolog 2

1

9

High-throughput

0.479

High

1381993

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.479

High

1400348

FMNL2
Formin-like protein 2

1

5

High-throughput

0.479

High

1418501

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

1418830

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

1433564

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1438225

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1438732

CPAP
Centrosomal P4.1-associated protein

1

3

High-throughput

0.479

High

1447402

ANLN
Anillin

1

4

High-throughput

0.479

High

1460063

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

1

High-throughput

0.479

High

184333

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

867492

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1249303

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1453022

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

62270

GRD2I
Delphilin

1

5

Small-scale

0.457

High

1207211

IQEC2
IQ motif and SEC7 domain-containing protein 2

1

3

Small-scale

0.457

High

330362

VENTX
Homeobox protein VENTX

1

4

High-throughput

0.445

High

1226309

CP135
Centrosomal protein of 135 kDa

1

4

High-throughput

0.445

High

1352138

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

12

High-throughput

0.445

High

1367522

ESR2
Estrogen receptor beta

1

9

High-throughput

0.445

High

1293191

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1454765

HECW2
E3 ubiquitin-protein ligase HECW2

1

8

High-throughput

0.437

High

1460057

XPO7
Exportin-7

1

1

High-throughput

0.437

High

1453420

MAT2B
Methionine adenosyltransferase 2 subunit beta

1

0

High-throughput

0.426

High

1059991

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

8

Small-scale

0.408

High

51334

NTM2F
NUT family member 2F

1

0

High-throughput

0.279

Low

1338683

T185A
Transmembrane protein 185A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025