HitPredict

Interactor 1: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Interactor 2: RNPC3 (Q96LT9)
RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K)
Gene: RNPC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 344 Hs			1 517
+	Hs
		446597 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		SNRPA_HUMAN (417-513): 2.71e-33: 129: 25.77
+	Hs
		446613 SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22		SNRPA_HUMAN (417-513): 2.71e-33: 129: 25.77
+	Hs
		446599 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		SNRPA_HUMAN (417-513): 2.71e-33: 129: 25.77
+	Hs
		446765 RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23		SNRPA_HUMAN (417-513): 2.71e-33: 129: 25.77
+	Hs
		992875 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		PABP5_HUMAN (325-507): 2.57e-14: 76.6: 15.85
+	Hs
		992961 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		RBM28_HUMAN (29-512): 6.11e-14: 76.6: 15.71
+	Hs
		1314631 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		RBM28_HUMAN (29-512): 6.11e-14: 76.6: 15.71
+	Hs
		1028593 SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22		PABP5_HUMAN (325-507): 2.57e-14: 76.6: 15.85
+	Hs
		993850 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		RBM28_HUMAN (29-512): 6.11e-14: 76.6: 15.71
+	Hs
		1028845 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		RBM28_HUMAN (29-512): 6.11e-14: 76.6: 15.71
+	Hs
		993879 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		RBM19_HUMAN (2-502): 4.44e-12: 70.8: 14.57
+	Hs
		474020 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		PAB4L_HUMAN (242-502): 1.9e-14: 77: 16.18
+	Hs
		1028887 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		RBM19_HUMAN (2-502): 4.44e-12: 70.8: 14.57
+	Hs
		1308813 RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23		RBM19_HUMAN (2-502): 4.44e-12: 70.8: 14.57
+	Hs
		1029129 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		RBM28_HUMAN (29-512): 6.11e-14: 76.6: 15.71
+	Hs
		1029175 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		RBM19_HUMAN (2-502): 4.44e-12: 70.8: 14.57
+	Hs
		474034 PAB4L_HUMAN (1-196): 1.97e-35: 134: 15.94		PABP5_HUMAN (325-507): 2.57e-14: 76.6: 15.85
+	Hs
		1119141 PAP1L_HUMAN (1-195): 2.15e-31: 126: 15.53		PABP5_HUMAN (325-507): 2.57e-14: 76.6: 15.85
+	Hs
		474021 PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88		PAB4L_HUMAN (242-502): 1.9e-14: 77: 16.18
+	Hs
		1347061 RBM28_HUMAN (4-248): 1.53e-12: 70.6: 14.61		RBM19_HUMAN (2-502): 4.44e-12: 70.8: 14.57