HitPredict

Interactor 1: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Interactor 2: MK67I (Q9BYG3)
MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK)
Gene: NIFK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 344 Hs			1 293
+	Hs
		992916 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		MK67I_HUMAN (1-293): 8.07e-53: 176: 100.00
+	Mm
		857324 Q542V3_MOUSE (1-343): 1.15e-52: 182: 51.93		TIA1_MOUSE (40-289): 5.79e-47: 163: 12.50
+	Mm
		857340 SRSF1_MOUSE (3-188): 3.02e-54: 180: 36.65		TIA1_MOUSE (40-289): 5.79e-47: 163: 12.50
+	Mm
		936481 SRSF1_MOUSE (3-188): 3.02e-54: 180: 36.65		TIAR_MOUSE (39-289): 1.35e-44: 157: 13.43
+	Hs
		1028804 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		MK67I_HUMAN (1-293): 8.07e-53: 176: 100.00
+	Hs
		1308758 RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23		MK67I_HUMAN (1-293): 8.07e-53: 176: 100.00
+	Hs
		516478 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		PABP1_HUMAN (35-225): 1.96e-40: 150: 14.14
+	Hs
		516674 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		PABP1_HUMAN (35-225): 1.96e-40: 150: 14.14
+	Hs
		516493 SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22		PABP1_HUMAN (35-225): 1.96e-40: 150: 14.14
+	Hs
		992875 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		PABP5_HUMAN (49-222): 2.56e-35: 132: 12.07
+	Hs
		992984 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		PUF60_HUMAN (31-234): 4.14e-30: 120: 17.96
+	Hs
		1028593 SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22		PABP5_HUMAN (49-222): 2.56e-35: 132: 12.07
+	Mm
		1207996 RBM4_MOUSE (1-343): 1.34e-43: 155: 18.18		CSTFT_MOUSE (46-219): 1.38e-37: 142: 20.11
+	Hs
		993005 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		RBMX2_HUMAN (14-235): 3.77e-30: 117: 17.54
+	Hs
		992743 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		ELAV2_HUMAN (38-128): 7.23e-24: 101: 26.37
+	Hs
		1028881 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		RBMX2_HUMAN (14-235): 3.77e-30: 117: 17.54
+	Hs
		1308809 RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23		RBMX2_HUMAN (14-235): 3.77e-30: 117: 17.54
+	Hs
		1020247 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		ELAV2_HUMAN (38-128): 7.23e-24: 101: 26.37
+	Hs
		474020 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		PAB4L_HUMAN (1-123): 1.69e-22: 97.5: 21.95
+	Hs
		1073633 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		SF3B4_HUMAN (26-283): 2.83e-17: 83.3: 11.92