Protein: E2F6
Transcription factor E2F6 (E2F-6)

Gene: E2F6
Organism: Homo sapiens
Interactions: 181
UniProt ID: O75461

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

282715

TFDP2
Transcription factor Dp-2

13

20

Small-scale

0.986

High

282714

TFDP1
Transcription factor Dp-1

13

20

Small-scale

0.985

High

282750

RYBP
RING1 and YY1-binding protein

8

4

Small-scale

0.753

High

282764

LMBL2
Lethal(3)malignant brain tumor-like protein 2

7

10

Small-scale

0.747

High

282776

PCGF6
Polycomb group RING finger protein 6

7

15

Small-scale

0.746

High

282694

WDR5
WD repeat-containing protein 5

6

4

Small-scale

0.735

High

282769

RING2
E3 ubiquitin-protein ligase RING2

6

17

Small-scale

0.733

High

282693

MAX
Protein max

5

6

Small-scale

0.718

High

282709

CBX3
Chromobox protein homolog 3

5

6

Small-scale

0.718

High

282746

MGAP
MAX gene-associated protein

5

4

High-throughput

0.718

High

282748

YAF2
YY1-associated factor 2

5

4

High-throughput

0.718

High

282711

HDAC1
Histone deacetylase 1

4

6

High-throughput

0.699

High

282780

COMD4
COMM domain-containing protein 4

5

0

High-throughput

0.686

High

282705

RING1
E3 ubiquitin-protein ligase RING1

3

17

Small-scale

0.681

High

282741

COMD6
COMM domain-containing protein 6

4

0

High-throughput

0.670

High

282790

COMD8
COMM domain-containing protein 8

4

0

High-throughput

0.667

High

282665

PRS6A
26S proteasome regulatory subunit 6A

3

4

High-throughput

0.667

High

282749

MIER2
Mesoderm induction early response protein 2

3

3

High-throughput

0.667

High

282751

COMD1
COMM domain-containing protein 1

3

0

High-throughput

0.646

High

282804

CARD8
Caspase recruitment domain-containing protein 8

3

0

High-throughput

0.638

High

282689

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

8

Small-scale

0.631

High

282700

CBX1
Chromobox protein homolog 1

2

6

High-throughput

0.628

High

282760

HDAC2
Histone deacetylase 2

2

6

High-throughput

0.628

High

143374

E2F3
Transcription factor E2F3

1

14

High-throughput

0.618

High

282654

RB
Retinoblastoma-associated protein

1

20

High-throughput

0.618

High

282702

E2F1
Transcription factor E2F1

1

14

High-throughput

0.618

High

282716

E2F2
Transcription factor E2F2

1

14

High-throughput

0.618

High

282723

E2F5
Transcription factor E2F5

1

14

High-throughput

0.618

High

282727

E2F4
Transcription factor E2F4

1

14

High-throughput

0.618

High

282787

CBX8
Chromobox protein homolog 8

2

6

High-throughput

0.611

High

282783

EPC1
Enhancer of polycomb homolog 1

2

1

Small-scale

0.606

High

282681

KDM5C
Lysine-specific demethylase 5C

2

0

Small-scale

0.602

High

282685

LEG7
Galectin-7

2

0

High-throughput

0.602

High

282803

TCF19
Transcription factor 19

2

0

High-throughput

0.602

High

282679

BMI1
Polycomb complex protein BMI-1

2

15

Small-scale

0.601

High

282726

EZH2
Histone-lysine N-methyltransferase EZH2

2

6

Small-scale

0.601

High

282646

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.584

High

282656

NFIC
Nuclear factor 1 C-type

2

17

High-throughput

0.584

High

282680

PCGF2
Polycomb group RING finger protein 2

2

15

Small-scale

0.584

High

282691

KLF3
Krueppel-like factor 3

2

9

High-throughput

0.584

High

282707

NFIA
Nuclear factor 1 A-type

2

16

High-throughput

0.584

High

282719

NFIX
Nuclear factor 1 X-type

2

17

High-throughput

0.584

High

282706

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

1

High-throughput

0.574

High

282789

ASB6
Ankyrin repeat and SOCS box protein 6

2

1

High-throughput

0.574

High

282759

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

2

High-throughput

0.542

High

282650

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.536

High

282666

FILA
Filaggrin

1

3

High-throughput

0.536

High

282675

S10A7
Protein S100-A7

1

2

High-throughput

0.536

High

282676

CASPE
Caspase-14

1

1

High-throughput

0.536

High

282677

S10AB
Protein S100-A11

1

2

High-throughput

0.536

High

282713

TRI29
Tripartite motif-containing protein 29

1

2

High-throughput

0.536

High

282717

RRP5
Protein RRP5 homolog

1

3

High-throughput

0.536

High

282773

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.536

High

282652

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

282657

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.513

High

282664

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

282728

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.513

High

282778

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.513

High

282798

DNM3L
DNA

1

4

Small-scale

0.501

High

282662

ARAF
Serine/threonine-protein kinase A-Raf

1

3

High-throughput

0.494

High

210627

KLK10
Kallikrein-10

1

1

High-throughput

0.489

High

261573

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

282645

CYTS
Cystatin-S

1

2

High-throughput

0.489

High

282653

APOD
Apolipoprotein D

1

1

High-throughput

0.489

High

282658

CYTT
Cystatin-SA

1

2

High-throughput

0.489

High

282659

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

282669

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.489

High

282674

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

282687

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

282725

CYTM
Cystatin-M

1

2

High-throughput

0.489

High

282734

ZMYM4
Zinc finger MYM-type protein 4

1

1

High-throughput

0.489

High

282767

CPNS2
Calpain small subunit 2

1

2

High-throughput

0.489

High

282672

DNMT1
DNA

1

3

Small-scale

0.481

High

282730

BRDT
Bromodomain testis-specific protein

1

16

Small-scale

0.481

High

282757

FOG2
Zinc finger protein ZFPM2

1

1

Small-scale

0.481

High

282791

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

5

Small-scale

0.481

High

282805

ZBT32
Zinc finger and BTB domain-containing protein 32

1

1

Small-scale

0.481

High

142755

NFIB
Nuclear factor 1 B-type

1

15

High-throughput

0.479

High

161383

KMT2D
Histone-lysine N-methyltransferase 2D

1

12

Small-scale

0.479

High

190761

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

209924

CRX
Cone-rod homeobox protein

1

6

High-throughput

0.479

High

239906

SOX15
Transcription factor SOX-15

1

6

High-throughput

0.479

High

246343

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.479

High

274270

SIN3B
Paired amphipathic helix protein Sin3b

1

2

Small-scale

0.479

High

282640

EED
Polycomb protein EED

1

3

Small-scale

0.479

High

282641

DNJC8
DnaJ homolog subfamily C member 8

1

3

High-throughput

0.479

High

282642

KLF8
Krueppel-like factor 8

1

11

High-throughput

0.479

High

282649

ESR1
Estrogen receptor

1

6

Small-scale

0.479

High

282655

LYN
Tyrosine-protein kinase Lyn

1

1

Small-scale

0.479

High

282661

MYB
Transcriptional activator Myb

1

6

High-throughput

0.479

High

282663

IRF1
Interferon regulatory factor 1

1

1

High-throughput

0.479

High

282673

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.479

High

282678

ELF1
ETS-related transcription factor Elf-1

1

6

High-throughput

0.479

High

282682

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

High-throughput

0.479

High

282683

ELK3
ETS domain-containing protein Elk-3

1

6

High-throughput

0.479

High

282686

CENPA
Histone H3-like centromeric protein A

1

3

High-throughput

0.479

High

282688

LHX2
LIM/homeobox protein Lhx2

1

3

High-throughput

0.479

High

282695

H4
Histone H4

1

1

High-throughput

0.479

High

282699

PHC1
Polyhomeotic-like protein 1

1

11

High-throughput

0.479

High

282703

KMT2A
Histone-lysine N-methyltransferase 2A

1

10

Small-scale

0.479

High

282704

MAD1
Max dimerization protein 1

1

7

Small-scale

0.479

High

282712

KLF9
Krueppel-like factor 9

1

11

High-throughput

0.479

High

282718

CBX2
Chromobox protein homolog 2

1

6

High-throughput

0.479

High

282720

BRD3
Bromodomain-containing protein 3

1

15

High-throughput

0.479

High

282721

IRF4
Interferon regulatory factor 4

1

1

High-throughput

0.479

High

282722

ZMY11
Zinc finger MYND domain-containing protein 11

1

13

Small-scale

0.479

High

282724

ELF2
ETS-related transcription factor Elf-2

1

5

High-throughput

0.479

High

282729

PCGF3
Polycomb group RING finger protein 3

1

15

High-throughput

0.479

High

282731

BCORL
BCL-6 corepressor-like protein 1

1

2

High-throughput

0.479

High

282736

BCOR
BCL-6 corepressor

1

2

High-throughput

0.479

High

282740

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

282742

PCGF5
Polycomb group RING finger protein 5

1

15

High-throughput

0.479

High

282743

PB1
Protein polybromo-1

1

10

Small-scale

0.479

High

282752

PHC3
Polyhomeotic-like protein 3

1

14

High-throughput

0.479

High

282754

NUP43
Nucleoporin Nup43

1

9

High-throughput

0.479

High

282755

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

282761

EZH1
Histone-lysine N-methyltransferase EZH1

1

6

Small-scale

0.479

High

282762

SMRC1
SWI/SNF complex subunit SMARCC1

1

9

Small-scale

0.479

High

282763

LHX4
LIM/homeobox protein Lhx4

1

3

High-throughput

0.479

High

282765

PF21A
PHD finger protein 21A

1

5

High-throughput

0.479

High

282766

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

13

Small-scale

0.479

High

282768

CIC
Protein capicua homolog

1

6

High-throughput

0.479

High

282770

FEV
Protein FEV

1

5

High-throughput

0.479

High

282771

ELF4
ETS-related transcription factor Elf-4

1

6

High-throughput

0.479

High

282774

PCGF1
Polycomb group RING finger protein 1

1

15

High-throughput

0.479

High

282775

KLF16
Krueppel-like factor 16

1

11

High-throughput

0.479

High

282784

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

8

High-throughput

0.479

High

282785

SOX17
Transcription factor SOX-17

1

8

High-throughput

0.479

High

282788

DJC17
DnaJ homolog subfamily C member 17

1

2

High-throughput

0.479

High

282792

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

282793

LHX3
LIM/homeobox protein Lhx3

1

3

High-throughput

0.479

High

282794

ZMYM2
Zinc finger MYM-type protein 2

1

1

High-throughput

0.479

High

282795

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

282797

KLF15
Krueppel-like factor 15

1

11

High-throughput

0.479

High

282799

RCOR1
REST corepressor 1

1

6

High-throughput

0.479

High

282800

ELF5
ETS-related transcription factor Elf-5

1

5

High-throughput

0.479

High

282801

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

9

Small-scale

0.479

High

282802

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

3

Small-scale

0.479

High

282807

KLF12
Krueppel-like factor 12

1

10

High-throughput

0.479

High

282670

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.460

High

282708

ZBT17
Zinc finger and BTB domain-containing protein 17

1

0

Small-scale

0.460

High

282738

CENPU
Centromere protein U

1

0

Small-scale

0.460

High

282777

IN80B
INO80 complex subunit B

1

0

Small-scale

0.460

High

282781

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

Small-scale

0.460

High

279244

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

282671

DNJB1
DnaJ homolog subfamily B member 1

1

0

High-throughput

0.458

High

282690

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

High-throughput

0.458

High

282696

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

282698

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

282732

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.458

High

282758

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

282779

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

282806

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

282651

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

282710

PD2R
Prostaglandin D2 receptor

1

1

Small-scale

0.437

High

282744

MIB1
E3 ubiquitin-protein ligase MIB1

1

4

High-throughput

0.437

High

282747

DHX40
Probable ATP-dependent RNA helicase DHX40

1

3

High-throughput

0.437

High

282647

IGHG1
Immunoglobulin heavy constant gamma 1

1

1

High-throughput

0.407

High

282756

POF1B
Protein POF1B

2

0

High-throughput

0.328

High

282692

KR107
Keratin-associated protein 10-7

1

0

High-throughput

0.299

High

276545

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

282643

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.279

Low

282644

PLMN
Plasminogen

1

0

High-throughput

0.279

Low

282648

SMR3B
Submaxillary gland androgen-regulated protein 3B

1

0

High-throughput

0.279

Low

282667

SPR1B
Cornifin-B

1

0

High-throughput

0.279

Low

282668

SPR2E
Small proline-rich protein 2E

1

0

High-throughput

0.279

Low

282684

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.279

Low

282697

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.279

Low

282733

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.279

Low

282735

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

282737

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

282739

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

282745

SPA12
Serpin A12

1

0

High-throughput

0.279

Low

282753

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

0

High-throughput

0.279

Low

282772

DHB14
L-fucose dehydrogenase

1

0

High-throughput

0.279

Low

282782

RNAS7
Ribonuclease 7

1

0

High-throughput

0.279

Low

282796

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

156767

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

282701

REEP5
Receptor expression-enhancing protein 5

1

0

Small-scale

0.249

Low

282786

FBRS
Probable fibrosin-1

1

0

High-throughput

0.249

Low

282660

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025