HitPredict

Interactor 1: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Interactor 2: SETD2 (Q9BYW2)
Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)
Gene: SETD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 344 Hs			1 2564
+	Hs
		331795 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		331802 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		331871 RBM4B_HUMAN (1-343): 2.62e-45: 160: 18.23		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		331803 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Sc
		633962 GBP2_YEAST (4-203): 4.8e-23: 100: 19.05		SET2_YEAST (1455-2006): 3.08e-92: 319: 23.74
+	Sc
		376833 PABP_YEAST (99-194): 1.33e-11: 67.6: 19.80		SET2_YEAST (1455-2006): 3.08e-92: 319: 23.74
+	Hs
		516645 PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79		NSD1_HUMAN (1458-1727): 5.38e-73: 275: 32.73
+	Hs
		992789 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Hs
		1028558 SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Hs
		1028670 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Hs
		1031345 PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Hs
		1080399 RBM28_HUMAN (4-248): 1.53e-12: 70.6: 14.61		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Hs
		516536 PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Hs
		963528 TIAR_HUMAN (102-272): 2.65e-09: 59.9: 13.19		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Mm
		952203 SRSF3_MOUSE (3-78): 2.4e-09: 57.4: 46.84		Q6AXH7_MOUSE (1539-1670): 3.81e-17: 90.5: 36.36
+	Hs
		951979 SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36