HitPredict

Interactor 1: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	26725010, 29845934
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 835 Hs			1 582
+	Hs
		1029838 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Hs
		1029459 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		584976 RO52_HUMAN (104-502): 1.58e-48: 180: 12.94		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		668779 PML_HUMAN (29-609): 1.21e-57: 214: 14.00		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		403371 TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		1102496 LIN41_HUMAN (142-395): 1.53e-66: 240: 24.19		PABP5_HUMAN (12-206): 7.64e-32: 128: 14.15
+	Hs
		1174875 TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		170212 TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		516745 TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		262171 TRIM3_HUMAN (122-628): 2.47e-53: 200: 15.85		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Mm
		1207399 TRIM8_MOUSE (59-590): 3.71e-48: 181: 15.52		LARP4_MOUSE (22-216): 3.47e-40: 157: 21.32
+	Dm
		582655 Q9W378_DROME (4-422): 4.17e-56: 211: 18.44		SXL_DROME (59-259): 1.13e-24: 107: 20.29
+	Mm
		857386 TRIM2_MOUSE (109-628): 3.73e-52: 196: 14.63		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		668769 PML_HUMAN (29-609): 1.21e-57: 214: 14.00		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		170377 TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		584970 RO52_HUMAN (104-502): 1.58e-48: 180: 12.94		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50