HitPredict - High confidence protein-protein interactions

Interactor 1: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Interactor 2: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	17254749, 22770219
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	F-box-like~F-box-like
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0000086 - G2/M transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus and 14 others more... GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0033148 - positive regulation of intracellular estrogen receptor signaling pathway GO:0042981 - regulation of apoptotic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045087 - innate immune response GO:0051607 - defense response to virus GO:0051726 - regulation of cell cycle GO:0070534 - protein K63-linked ubiquitination GO:0070936 - protein K48-linked ubiquitination GO:1902916 - positive regulation of protein polyubiquitination GO:1905168 - positive regulation of double-strand break repair via homologous recombination GO:1990756 - ubiquitin-like ligase-substrate adaptor activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	424
Hs

1	424

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Last updated: 15 Jul 2024