HitPredict

Interactor 1: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Interactor 2: PAN2 (Q504Q3)
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2)
Gene: PAN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 23398456
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 644 Hs			1 1202
+	Hs
		516542 PABP1_HUMAN (1-644): 0: 542: 74.54		PAN2_HUMAN (1-1202): 0: 1136: 100.00
+	Hs
		582323 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		PAN2_HUMAN (1-1202): 0: 1136: 100.00
+	Hs
		516625 PABP1_HUMAN (1-644): 0: 542: 74.54		UBP7_HUMAN (340-1038): 1.3e-89: 315: 12.02
+	Hs
		516747 PABP1_HUMAN (1-644): 0: 542: 74.54		UBP22_HUMAN (462-854): 5.81e-86: 291: 12.30
+	Sc
		376857 PABP_YEAST (2-290): 4.28e-66: 228: 30.07		PAN2_YEAST (71-1186): 5.22e-176: 550: 22.50
+	Sc
		376803 PABP_YEAST (2-290): 4.28e-66: 228: 30.07		UTP7_YEAST (35-461): 8e-81: 278: 15.37
+	Hs
		171727 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		WDR46_HUMAN (35-483): 2.12e-94: 317: 12.19
+	Hs
		69565 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		B0UZZ8_HUMAN (35-483): 2.12e-94: 317: 12.19
+	Hs
		582419 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		UBP7_HUMAN (340-1038): 1.3e-89: 315: 12.02
+	Hs
		1220120 PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33		GOR_HUMAN (951-1156): 1.52e-46: 180: 21.91