Protein: TWF1
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)

Gene: TWF1
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q12792

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0003785 - actin monomer binding
GO:0005524 - ATP binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1085885

DREB
Drebrin

3

3

High-throughput

0.855

High

952782

ACTB
Actin, cytoplasmic 1

3

20

High-throughput

0.847

High

867081

CAPZB
F-actin-capping protein subunit beta

3

5

High-throughput

0.839

High

1085890

TWF2
Twinfilin-2

2

13

High-throughput

0.737

High

660046

COF1
Cofilin-1

1

12

High-throughput

0.691

High

837214

ACTY
Beta-centractin

1

20

High-throughput

0.691

High

958093

ARP3
Actin-related protein 3

1

20

High-throughput

0.691

High

958254

ARP2
Actin-related protein 2

1

20

High-throughput

0.691

High

993148

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.691

High

1054101

BTK
Tyrosine-protein kinase BTK

1

2

Small-scale

0.691

High

1085933

ARP10
Actin-related protein 10

1

20

High-throughput

0.691

High

995558

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.665

High

866659

CAZA2
F-actin-capping protein subunit alpha-2

3

6

High-throughput

0.662

High

1085927

ANLN
Anillin

3

3

High-throughput

0.656

High

123680

MYO1C
Unconventional myosin-Ic

2

11

High-throughput

0.628

High

920433

DAPK1
Death-associated protein kinase 1

2

6

High-throughput

0.628

High

1085937

LIMA1
LIM domain and actin-binding protein 1

2

4

High-throughput

0.628

High

1085926

TIGAR
Fructose-2,6-bisphosphatase TIGAR

2

1

High-throughput

0.621

High

363196

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.618

High

411825

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.618

High

958420

ACTZ
Alpha-centractin

1

20

High-throughput

0.618

High

995007

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.580

High

277922

SH3L1
Adapter SH3BGRL

2

3

High-throughput

0.571

High

395996

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

635713

RASA1
Ras GTPase-activating protein 1

2

8

High-throughput

0.571

High

1085889

A16L1
Autophagy-related protein 16-1

2

5

High-throughput

0.571

High

132467

CDC7
Cell division cycle 7-related protein kinase

1

5

High-throughput

0.536

High

179197

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

3

High-throughput

0.536

High

427882

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.536

High

637478

FLNA
Filamin-A

1

4

High-throughput

0.536

High

772767

MYH9
Myosin-9

1

4

High-throughput

0.536

High

818793

CAP2
Adenylyl cyclase-associated protein 2

1

10

High-throughput

0.536

High

862819

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.536

High

915070

CAZA1
F-actin-capping protein subunit alpha-1

1

6

High-throughput

0.536

High

968272

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

4

High-throughput

0.536

High

983463

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

High-throughput

0.536

High

984087

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.536

High

1030722

CAP1
Adenylyl cyclase-associated protein 1

1

10

High-throughput

0.536

High

1052000

CALD1
Caldesmon

1

11

High-throughput

0.536

High

1085876

SQSTM
Sequestosome-1

1

2

High-throughput

0.536

High

1085879

SCRB2
Lysosome membrane protein 2

1

2

High-throughput

0.536

High

1085881

DCTN1
Dynactin subunit 1

1

6

High-throughput

0.536

High

1085882

SRC8
Src substrate cortactin

1

4

High-throughput

0.536

High

1085892

RHGBA
Rho GTPase-activating protein 11A

1

1

High-throughput

0.536

High

1085898

SYNPO
Synaptopodin

1

4

High-throughput

0.536

High

1085908

MY18A
Unconventional myosin-XVIIIa

1

8

High-throughput

0.536

High

1085913

MYO19
Unconventional myosin-XIX

1

7

High-throughput

0.536

High

1085923

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

2

High-throughput

0.536

High

1085932

TMOD3
Tropomodulin-3

1

4

High-throughput

0.536

High

1085936

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

1

High-throughput

0.536

High

1085939

COR1C
Coronin-1C

1

7

High-throughput

0.536

High

1085943

SCIN
Scinderin

1

1

High-throughput

0.536

High

460811

CATB
Cathepsin B

1

1

High-throughput

0.515

High

692944

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

391017

TRFL
Lactotransferrin

1

0

High-throughput

0.513

High

948417

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.513

High

1010291

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.513

High

1085877

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.513

High

1085912

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

1085915

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1085938

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.513

High

422004

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1085901

FBX25
F-box only protein 25

1

3

Small-scale

0.501

High

390555

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

230630

PRIC3
Prickle planar cell polarity protein 3

1

1

High-throughput

0.489

High

1085884

AINX
Alpha-internexin

1

4

High-throughput

0.489

High

1085902

BPIB1
BPI fold-containing family B member 1

1

1

High-throughput

0.489

High

1085904

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

3

High-throughput

0.489

High

1085924

MUC5B
Mucin-5B

1

2

High-throughput

0.489

High

1085925

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.489

High

136083

PLK4
Serine/threonine-protein kinase PLK4

1

2

Small-scale

0.479

High

241523

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

247863

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

293629

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

319715

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

330913

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.479

High

371882

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

457393

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

474637

VIME
Vimentin

1

4

High-throughput

0.479

High

556046

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

629817

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

862076

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

897771

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.479

High

929923

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

966249

1433G
14-3-3 protein gamma

1

5

High-throughput

0.479

High

976231

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

1031353

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1085875

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

High-throughput

0.479

High

1085880

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

5

High-throughput

0.479

High

1085883

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

1085888

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

1085894

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1085895

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1085896

CUL9
Cullin-9

1

3

High-throughput

0.479

High

1085899

FBXW8
F-box/WD repeat-containing protein 8

1

3

High-throughput

0.479

High

1085900

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1085903

STYX
Serine/threonine/tyrosine-interacting protein

1

6

High-throughput

0.479

High

1085907

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

1085909

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1085917

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1085919

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

1085920

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1085921

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

1085931

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.479

High

1085935

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

842343

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.458

High

959142

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1085893

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1085910

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1085922

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1085928

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

529709

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

563690

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

765449

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

1085891

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

1085897

PALS1
Protein PALS1

1

2

High-throughput

0.445

High

1085906

SSH1
Protein phosphatase Slingshot homolog 1

1

6

High-throughput

0.445

High

1085929

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

1085941

COR2B
Coronin-2B

1

8

High-throughput

0.445

High

213121

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

Small-scale

0.438

High

105830

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

560382

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

588560

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

695315

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

768056

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

944983

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.437

High

1085905

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1085911

KCD12
BTB/POZ domain-containing protein KCTD12

1

8

Small-scale

0.437

High

1085914

RHOV
Rho-related GTP-binding protein RhoV

1

3

High-throughput

0.437

High

1085918

RHBT2
Rho-related BTB domain-containing protein 2

1

5

High-throughput

0.437

High

1085930

CCD87
Coiled-coil domain-containing protein 87

1

1

High-throughput

0.437

High

1085940

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

379637

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.407

High

379735

IGHA2
Immunoglobulin heavy constant alpha 2

1

2

High-throughput

0.407

High

1022239

MUC5A
Mucin-5AC

1

3

High-throughput

0.407

High

1085886

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

3

High-throughput

0.407

High

1085916

ZBT18
Zinc finger and BTB domain-containing protein 18

1

3

High-throughput

0.407

High

369455

AACT
Alpha-1-antichymotrypsin

1

0

High-throughput

0.279

Low

378681

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

378984

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.279

Low

484509

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

963173

LYSC
Lysozyme C

1

0

High-throughput

0.279

Low

1085874

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.279

Low

1085878

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

1085934

GBG12

1

0

High-throughput

0.279

Low

142968

NFIB
Nuclear factor 1 B-type

1

0

High-throughput

0.249

Low

188873

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.249

Low

378073

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

680697

CATS
Cathepsin S

1

0

High-throughput

0.249

Low

1085942

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

379096

IGKC
Immunoglobulin kappa constant

1

0

High-throughput

0.232

Low

1085887

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025