HitPredict

Interactor 1: ILK (Q13418)
Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK)
Gene: ILK

Interactor 2: SH2B3 (Q9UQQ2)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22441983
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 452 Hs			1 575
+	Hs
		411892 LCK_HUMAN (167-449): 1.86e-109: 334: 21.99		SH2B3_HUMAN (1-575): 4.13e-166: 486: 100.00
+	Hs
		209048 ILK_HUMAN (1-452): 1.6e-146: 427: 100.00		NCK2_HUMAN (237-453): 3.16e-38: 146: 16.07
+	Hs
		666098 ILK_HUMAN (1-452): 1.6e-146: 427: 100.00		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Hs
		788963 ILK_HUMAN (1-452): 1.6e-146: 427: 100.00		MATK_HUMAN (343-444): 6e-22: 101: 32.35
+	Mm
		411932 LCK_MOUSE (167-449): 1.31e-109: 334: 21.99		SOCS6_MOUSE (77-464): 1.03e-51: 187: 16.71
+	Hs
		411580 LCK_HUMAN (167-449): 1.86e-109: 334: 21.99		VAV_HUMAN (192-573): 3.94e-49: 184: 11.77
+	Hs
		411573 LCK_HUMAN (167-449): 1.86e-109: 334: 21.99		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Hs
		411552 LCK_HUMAN (167-449): 1.86e-109: 334: 21.99		YES_HUMAN (229-557): 2.62e-45: 169: 13.20
+	Hs
		522734 SRC_HUMAN (173-448): 1.71e-98: 307: 24.56		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Gg
		337663 SRC_CHICK (173-448): 8.64e-99: 307: 24.56		SRC_CHICK (225-539): 1.19e-45: 170: 14.68
+	Hs
		433231 SRC_HUMAN (173-448): 1.71e-98: 307: 24.56		YES_HUMAN (229-557): 2.62e-45: 169: 13.20
+	Hs
		411626 LCK_HUMAN (167-449): 1.86e-109: 334: 21.99		CSK_HUMAN (354-444): 2.06e-32: 131: 29.67
+	Hs
		411633 LCK_HUMAN (167-449): 1.86e-109: 334: 21.99		KSYK_HUMAN (363-573): 4.78e-25: 111: 15.57
+	Hs
		522833 SRC_HUMAN (173-448): 1.71e-98: 307: 24.56		CSK_HUMAN (354-444): 2.06e-32: 131: 29.67
+	Hs
		522805 SRC_HUMAN (173-448): 1.71e-98: 307: 24.56		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Hs
		129163 LCK_HUMAN (167-449): 1.86e-109: 334: 21.99		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38
+	Hs
		522845 SRC_HUMAN (173-448): 1.71e-98: 307: 24.56		KSYK_HUMAN (363-573): 4.78e-25: 111: 15.57
+	Hs
		522839 SRC_HUMAN (173-448): 1.71e-98: 307: 24.56		MATK_HUMAN (343-444): 6e-22: 101: 32.35
+	Hs
		522758 SRC_HUMAN (173-448): 1.71e-98: 307: 24.56		PLCG1_HUMAN (348-575): 7.81e-20: 96.2: 14.96
+	Hs
		129185 SRC_HUMAN (173-448): 1.71e-98: 307: 24.56		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38