Protein: RPF1
Ribosome production factor 1 (Ribosome biogenesis protein RPF1)

Gene: RPF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 165
UniProt ID: P38805

Gene Ontology (top 5):
GO:0000055 - ribosomal large subunit export from nucleus
GO:0000460 - maturation of 5.8S rRNA
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 - maturation of LSU-rRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

782327

RPF2
Ribosome biogenesis protein RPF2

5

2

Small-scale

0.908

High

804608

SSF1
Ribosome biogenesis protein SSF1

5

2

Small-scale

0.903

High

534107

MAK16
Protein MAK16

4

2

High-throughput

0.881

High

805104

BRX1
Ribosome biogenesis protein BRX1

3

8

High-throughput

0.848

High

805098

RRP15
Ribosomal RNA-processing protein 15

3

0

Small-scale

0.775

High

780260

EBP2
rRNA-processing protein EBP2

2

1

High-throughput

0.759

High

805069

NSA1
Ribosome biogenesis protein NSA1

8

2

Small-scale

0.749

High

805091

ERB1
Ribosome biogenesis protein ERB1

2

1

High-throughput

0.737

High

805108

RRS1
Regulator of ribosome biosynthesis

2

1

High-throughput

0.737

High

805084

HAS1
ATP-dependent RNA helicase HAS1

6

6

High-throughput

0.729

High

805070

PESC
Pescadillo homolog

6

1

Small-scale

0.727

High

805117

IF6
Eukaryotic translation initiation factor 6

5

1

Small-scale

0.714

High

805112

SSF2
Ribosome biogenesis protein SSF2

2

2

High-throughput

0.712

High

805073

NOP15
Ribosome biogenesis protein 15

5

3

High-throughput

0.712

High

805055

NOP2
25S rRNA

5

4

Small-scale

0.709

High

780675

RRP14
Ribosomal RNA-processing protein 14

2

0

High-throughput

0.699

High

805081

NOG1
Nucleolar GTP-binding protein 1

5

1

Small-scale

0.699

High

805047

NOC2
Nucleolar complex protein 2

6

0

High-throughput

0.695

High

805110

YTM1
Ribosome biogenesis protein YTM1

4

1

High-throughput

0.691

High

803858

CIC1
Proteasome-interacting protein CIC1

4

4

High-throughput

0.687

High

805054

RLP7
Ribosome biogenesis protein RLP7

4

2

Small-scale

0.678

High

805115

DBP10
ATP-dependent RNA helicase DBP10

4

3

High-throughput

0.672

High

793475

MAK5
ATP-dependent RNA helicase MAK5

3

5

High-throughput

0.670

High

682274

SPB4
ATP-dependent rRNA helicase SPB4

3

5

High-throughput

0.656

High

684717

RL5
Large ribosomal subunit protein uL18

2

0

High-throughput

0.649

High

805089

PUF6
Pumilio homology domain family member 6

4

0

Small-scale

0.649

High

677199

SPB1
27S pre-rRNA

3

1

High-throughput

0.646

High

763069

RRP1
Ribosomal RNA-processing protein 1

3

3

Small-scale

0.643

High

805059

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

0

High-throughput

0.622

High

746624

DRS1
ATP-dependent RNA helicase DRS1

2

5

High-throughput

0.611

High

805050

NUG1
Nuclear GTP-binding protein NUG1

2

2

High-throughput

0.611

High

633159

MAK11
Protein MAK11

3

0

Small-scale

0.606

High

432572

RL7A
Large ribosomal subunit protein uL30A

2

2

High-throughput

0.601

High

805113

MAK21
Ribosome biogenesis protein MAK21

2

4

High-throughput

0.594

High

798211

ENP1
Essential nuclear protein 1

2

1

High-throughput

0.584

High

433200

RL17A
Large ribosomal subunit protein uL22A

1

2

High-throughput

0.575

High

149750

RS9A
Small ribosomal subunit protein uS4A

2

3

High-throughput

0.571

High

410118

RL25
Large ribosomal subunit protein uL23

2

1

High-throughput

0.571

High

512428

RS6A
Small ribosomal subunit protein eS6A

2

2

High-throughput

0.571

High

689026

RL16A
Large ribosomal subunit protein uL13A

2

2

High-throughput

0.571

High

750078

MRT4
Ribosome assembly factor MRT4

2

2

High-throughput

0.571

High

805045

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

2

High-throughput

0.571

High

805094

FKBP4
FK506-binding protein 4

2

2

High-throughput

0.571

High

805096

DBP9
ATP-dependent RNA helicase DBP9

2

2

High-throughput

0.571

High

805101

NOC3
Nucleolar complex-associated protein 3

2

3

High-throughput

0.571

High

805109

NIP7
60S ribosome subunit biogenesis protein NIP7

2

1

High-throughput

0.571

High

805062

URB2
Nucleolar pre-ribosomal-associated protein 2

2

0

High-throughput

0.569

High

689442

RS7A
Small ribosomal subunit protein eS7A

2

0

High-throughput

0.563

High

805085

RRP17
Ribosomal RNA-processing protein 17

2

0

High-throughput

0.559

High

435951

RS13
Small ribosomal subunit protein uS15

2

0

High-throughput

0.547

High

441896

RS14A
Small ribosomal subunit protein uS11A

2

0

High-throughput

0.547

High

805049

NOP16
Nucleolar protein 16

2

0

High-throughput

0.547

High

805051

NSA2
Ribosome biogenesis protein NSA2

2

0

High-throughput

0.547

High

805087

RRB1
Ribosome assembly protein RRB1

2

0

High-throughput

0.547

High

805044

RPF1
Ribosome production factor 1

1

0

High-throughput

0.546

High

712562

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.536

High

721920

XPO1
Exportin-1

1

2

High-throughput

0.536

High

433628

RL26A
Large ribosomal subunit protein uL24A

2

4

High-throughput

0.521

High

435077

RS3
Small ribosomal subunit protein uS3

2

1

High-throughput

0.521

High

436405

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

2

2

High-throughput

0.521

High

455050

RS19A
Small ribosomal subunit protein eS19A

2

2

High-throughput

0.521

High

503031

RS22A
Small ribosomal subunit protein uS8A

2

2

High-throughput

0.521

High

511194

RL20B
Large ribosomal subunit protein eL20B

2

2

High-throughput

0.521

High

523870

HSP71
Heat shock protein SSA1

2

3

High-throughput

0.521

High

747350

RSSA1
Small ribosomal subunit protein uS2A

2

2

High-throughput

0.521

High

434158

RL36A
Large ribosomal subunit protein eL36A

1

2

High-throughput

0.514

High

514138

RS16B
Small ribosomal subunit protein uS9B

1

1

High-throughput

0.514

High

805068

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.513

High

805065

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.489

High

805079

RL6A
Large ribosomal subunit protein eL6A

1

0

High-throughput

0.481

High

805082

KA120
Importin beta-like protein KAP120

1

2

Small-scale

0.481

High

674611

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

677388

KRR1
KRR1 small subunit processome component

1

3

High-throughput

0.479

High

805058

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

805061

MTR4
ATP-dependent RNA helicase DOB1

1

1

Small-scale

0.479

High

805071

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.479

High

805075

RCM1
25S rRNA

1

4

High-throughput

0.479

High

805086

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

805090

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.479

High

805095

JIP5
WD repeat-containing protein JIP5

1

1

High-throughput

0.479

High

805099

NOC4
Nucleolar complex protein 4

1

4

High-throughput

0.479

High

805102

RLP24
Ribosome biogenesis protein RLP24

1

1

High-throughput

0.479

High

805103

NOP12
Nucleolar protein 12

1

3

High-throughput

0.479

High

805111

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.479

High

805116

NOP58
Nucleolar protein 58

1

5

High-throughput

0.479

High

791055

NOP4
Nucleolar protein 4

1

0

High-throughput

0.458

High

795815

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

805072

NOP13
Nucleolar protein 13

1

0

High-throughput

0.458

High

509539

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.457

High

805048

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

Small-scale

0.457

High

805060

NMD5
Nonsense-mediated mRNA decay protein 5

1

3

Small-scale

0.457

High

805067

IMB5
Importin subunit beta-5

1

2

Small-scale

0.457

High

513498

RL1A
Large ribosomal subunit protein uL1A

1

6

High-throughput

0.445

High

515253

RL35A
Large ribosomal subunit protein uL29A

1

1

High-throughput

0.445

High

585272

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.445

High

601041

RL8A
Large ribosomal subunit protein eL8A

1

3

High-throughput

0.445

High

781184

RL14A
Large ribosomal subunit protein eL14A

1

2

High-throughput

0.445

High

381094

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

381510

H2B2
Histone H2B.2

1

1

High-throughput

0.437

High

419725

H2A2
Histone H2A.2

1

2

High-throughput

0.437

High

707031

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

708730

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

734967

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.437

High

794972

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

805046

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

805053

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

805076

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.437

High

805093

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

805097

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

805105

SGO1
Shugoshin

1

1

High-throughput

0.437

High

805107

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

383306

RL28
Large ribosomal subunit protein uL15

1

1

High-throughput

0.407

High

394532

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

434369

RL15A
Large ribosomal subunit protein eL15A

1

1

High-throughput

0.407

High

503386

RL11A
Large ribosomal subunit protein uL5A

1

2

High-throughput

0.407

High

504199

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.407

High

511416

RL43B
Large ribosomal subunit protein eL43B

1

2

High-throughput

0.407

High

513682

RL2A
Large ribosomal subunit protein uL2A

1

2

High-throughput

0.407

High

513995

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.407

High

526633

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.407

High

531730

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.407

High

544793

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.407

High

569779

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.407

High

570007

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.407

High

741532

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.407

High

805057

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.407

High

805118

RL13A
Large ribosomal subunit protein eL13A

1

2

High-throughput

0.407

High

383690

RS17A
Small ribosomal subunit protein eS17A

2

0

High-throughput

0.298

High

514628

RS18A
Small ribosomal subunit protein uS13A

2

0

High-throughput

0.298

High

753358

RS3A1
Small ribosomal subunit protein eS1A

2

0

High-throughput

0.298

High

792033

GBLP
Small ribosomal subunit protein RACK1

2

0

High-throughput

0.298

High

802158

RS20
Small ribosomal subunit protein uS10

2

0

High-throughput

0.298

High

805063

RS12
Small ribosomal subunit protein eS12

2

0

High-throughput

0.298

High

805083

PKH3
Serine/threonine-protein kinase PKH3

1

0

High-throughput

0.279

Low

805106

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.279

Low

704599

SBA1
Co-chaperone protein SBA1

1

0

Small-scale

0.261

Low

805092

IMB1
Importin subunit beta-1

1

0

Small-scale

0.261

Low

805114

GIN4
Serine/threonine-protein kinase GIN4

1

0

High-throughput

0.261

Low

792515

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.253

Low

382086

H4
Histone H4

1

0

High-throughput

0.249

Low

512998

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

558711

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

752232

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

778318

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

805052

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.249

Low

805074

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.249

Low

805077

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

805078

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

805088

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

805100

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

432837

RL9A
Large ribosomal subunit protein uL6A

1

0

High-throughput

0.232

Low

434016

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.232

Low

502726

RS21A
Small ribosomal subunit protein eS21A

1

0

High-throughput

0.232

Low

503789

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.232

Low

511792

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.232

Low

512073

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.232

Low

514283

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.232

Low

515095

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.232

Low

688882

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.232

Low

805056

RS29A
Small ribosomal subunit protein uS14A

1

0

High-throughput

0.232

Low

805064

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.232

Low

805066

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low

805080

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.232

Low

805119

RS28A
Small ribosomal subunit protein eS28A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025