Protein: SSF1
Ribosome biogenesis protein SSF1

Gene: SSF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 172
UniProt ID: P38789

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005730 - nucleolus
GO:0008361 - regulation of cell size
GO:0019843 - rRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

780259

EBP2
rRNA-processing protein EBP2

9

2

Small-scale

0.964

High

782325

RPF2
Ribosome biogenesis protein RPF2

7

1

Small-scale

0.952

High

804660

ERB1
Ribosome biogenesis protein ERB1

6

2

Small-scale

0.932

High

804669

RRP15
Ribosomal RNA-processing protein 15

5

1

High-throughput

0.920

High

804608

RPF1
Ribosome production factor 1

5

2

Small-scale

0.903

High

780674

RRP14
Ribosomal RNA-processing protein 14

5

0

Small-scale

0.865

High

804681

RRS1
Regulator of ribosome biosynthesis

2

1

High-throughput

0.776

High

804687

SSF2
Ribosome biogenesis protein SSF2

2

2

High-throughput

0.776

High

804649

NOG1
Nucleolar GTP-binding protein 1

14

3

Small-scale

0.759

High

804634

PESC
Pescadillo homolog

14

1

Small-scale

0.757

High

570004

RL3
Large ribosomal subunit protein uL3

12

1

Small-scale

0.755

High

804694

IF6
Eukaryotic translation initiation factor 6

11

1

Small-scale

0.754

High

534106

MAK16
Protein MAK16

2

3

Small-scale

0.754

High

684715

RL5
Large ribosomal subunit protein uL18

2

1

Small-scale

0.754

High

804607

SSF1
Ribosome biogenesis protein SSF1

2

2

Small-scale

0.754

High

804675

BRX1
Ribosome biogenesis protein BRX1

2

11

Small-scale

0.754

High

804689

MAK21
Ribosome biogenesis protein MAK21

11

4

Small-scale

0.752

High

804650

HAS1
ATP-dependent RNA helicase HAS1

10

10

Small-scale

0.749

High

804658

PUF6
Pumilio homology domain family member 6

8

3

Small-scale

0.742

High

804632

NSA1
Ribosome biogenesis protein NSA1

8

2

Small-scale

0.742

High

804685

YTM1
Ribosome biogenesis protein YTM1

7

3

Small-scale

0.740

High

804611

NOC2
Nucleolar complex protein 2

7

1

Small-scale

0.739

High

804621

RLP7
Ribosome biogenesis protein RLP7

7

4

Small-scale

0.737

High

804622

NOP2
25S rRNA

7

3

Small-scale

0.737

High

804692

DBP10
ATP-dependent RNA helicase DBP10

7

6

Small-scale

0.737

High

791053

NOP4
Nucleolar protein 4

6

2

Small-scale

0.722

High

803856

CIC1
Proteasome-interacting protein CIC1

6

3

Small-scale

0.722

High

515252

RL35A
Large ribosomal subunit protein uL29A

6

1

Small-scale

0.721

High

746623

DRS1
ATP-dependent RNA helicase DRS1

5

9

Small-scale

0.703

High

804662

RRP5
rRNA biogenesis protein RRP5

5

2

Small-scale

0.699

High

804617

NSA2
Ribosome biogenesis protein NSA2

4

1

Small-scale

0.686

High

804667

DBP9
ATP-dependent RNA helicase DBP9

4

5

Small-scale

0.678

High

804683

NIP7
60S ribosome subunit biogenesis protein NIP7

4

2

Small-scale

0.678

High

758208

URB1
Nucleolar pre-ribosomal-associated protein 1

5

0

High-throughput

0.676

High

750076

MRT4
Ribosome assembly factor MRT4

4

2

Small-scale

0.676

High

804615

NUG1
Nuclear GTP-binding protein NUG1

4

3

Small-scale

0.676

High

804672

NOC3
Nucleolar complex-associated protein 3

4

3

Small-scale

0.676

High

804673

RLP24
Ribosome biogenesis protein RLP24

4

2

Small-scale

0.676

High

793474

MAK5
ATP-dependent RNA helicase MAK5

3

10

Small-scale

0.643

High

682272

SPB4
ATP-dependent rRNA helicase SPB4

3

8

High-throughput

0.640

High

763068

RRP1
Ribosomal RNA-processing protein 1

3

3

Small-scale

0.640

High

781620

DBP7
ATP-dependent RNA helicase DBP7

3

7

Small-scale

0.640

High

804625

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

1

Small-scale

0.640

High

804642

NOP15
Ribosome biogenesis protein 15

3

3

High-throughput

0.640

High

433199

RL17A
Large ribosomal subunit protein uL22A

1

1

Small-scale

0.618

High

601040

RL8A
Large ribosomal subunit protein eL8A

3

4

Small-scale

0.585

High

633157

MAK11
Protein MAK11

2

4

Small-scale

0.584

High

677197

SPB1
27S pre-rRNA

2

2

High-throughput

0.584

High

804666

FKBP4
FK506-binding protein 4

2

1

Small-scale

0.584

High

585271

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.576

High

677926

YCQ6
Uncharacterized protein YCR016W

2

0

High-throughput

0.576

High

410116

RL25
Large ribosomal subunit protein uL23

2

1

High-throughput

0.571

High

597455

EF3A
Elongation factor 3A

2

0

High-throughput

0.563

High

798207

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

804614

NOP16
Nucleolar protein 16

2

0

Small-scale

0.559

High

804627

URB2
Nucleolar pre-ribosomal-associated protein 2

2

0

High-throughput

0.559

High

804647

RL6A
Large ribosomal subunit protein eL6A

1

0

High-throughput

0.546

High

585928

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.536

High

513497

RL1A
Large ribosomal subunit protein uL1A

2

5

Small-scale

0.533

High

751394

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

2

High-throughput

0.533

High

792031

GBLP
Small ribosomal subunit protein RACK1

2

2

High-throughput

0.533

High

569778

RL30
Large ribosomal subunit protein eL30

2

1

Small-scale

0.521

High

804648

RNT1
Ribonuclease 3

1

1

High-throughput

0.515

High

526627

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.504

High

804679

DIA2
Protein DIA2

1

1

High-throughput

0.489

High

427266

RLA0
Large ribosomal subunit protein uL10

1

2

Small-scale

0.479

High

435948

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

441895

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

512426

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

637217

PWP1
Periodic tryptophan protein 1

1

1

Small-scale

0.479

High

674608

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

677384

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

689025

RL16A
Large ribosomal subunit protein uL13A

1

2

Small-scale

0.479

High

738208

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

4

High-throughput

0.479

High

804609

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.479

High

804613

SNU13
13 kDa ribonucleoprotein-associated protein

1

4

High-throughput

0.479

High

804623

RL10
Large ribosomal subunit protein uL16

1

1

Small-scale

0.479

High

804637

YG5X
Putative methyltransferase YGR283C

1

2

High-throughput

0.479

High

804639

DBP6
ATP-dependent RNA helicase DBP6

1

6

High-throughput

0.479

High

804655

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

804656

RRB1
Ribosome assembly protein RRB1

1

1

High-throughput

0.479

High

804670

NOC4
Nucleolar complex protein 4

1

4

High-throughput

0.479

High

804674

NOP12
Nucleolar protein 12

1

4

High-throughput

0.479

High

804676

REXO4
RNA exonuclease 4

1

2

High-throughput

0.479

High

804686

NOP53
Ribosome biogenesis protein NOP53

1

3

High-throughput

0.479

High

804693

NOP58
Nucleolar protein 58

1

1

High-throughput

0.479

High

804616

IMB4
Importin subunit beta-4

1

1

High-throughput

0.470

High

149748

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

514626

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

670678

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

672882

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

673560

NLE1
Ribosome assembly protein 4

1

0

High-throughput

0.458

High

689440

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

782160

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

804618

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

804624

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

804635

SDA1
Protein SDA1

1

0

High-throughput

0.458

High

804636

PXR1
Protein PXR1

1

0

Small-scale

0.458

High

804640

NOP13
Nucleolar protein 13

1

0

High-throughput

0.458

High

804651

ARX1
Probable metalloprotease ARX1

1

0

High-throughput

0.458

High

804653

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

804654

UTP5
U3 small nucleolar RNA-associated protein 5

1

0

High-throughput

0.458

High

804659

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

804664

RSA3
Ribosome assembly protein 3

1

0

High-throughput

0.458

High

804668

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

804677

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

432570

RL7A
Large ribosomal subunit protein uL30A

1

4

High-throughput

0.445

High

804690

RL7B
Large ribosomal subunit protein uL30B

1

4

High-throughput

0.445

High

382085

H4
Histone H4

1

1

High-throughput

0.437

High

433626

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

435074

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

455049

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

504198

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

511415

RL43B
Large ribosomal subunit protein eL43B

1

1

Small-scale

0.437

High

512995

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

531729

RL4A
Large ribosomal subunit protein uL4A

1

3

High-throughput

0.437

High

707021

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

747349

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

753356

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

804644

H3
Histone H3

1

2

High-throughput

0.437

High

804661

YM91
Putative methyltransferase YMR310C

1

2

High-throughput

0.437

High

804678

SGO1
Shugoshin

1

1

High-throughput

0.437

High

804680

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

434368

RL15A
Large ribosomal subunit protein eL15A

1

1

High-throughput

0.407

High

523862

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

712561

RL8B
Large ribosomal subunit protein eL8B

1

4

High-throughput

0.407

High

804630

RL4B
Large ribosomal subunit protein uL4B

1

3

High-throughput

0.407

High

804682

HSP33
Probable glutathione-independent glyoxalase HSP33

1

1

High-throughput

0.407

High

804684

HSP32
Probable glutathione-independent glyoxalase HSP32

1

1

High-throughput

0.407

High

804619

ULP2
Ubiquitin-like-specific protease 2

2

0

High-throughput

0.306

High

436402

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

2

0

High-throughput

0.305

High

792514

RL32
Large ribosomal subunit protein eL32

2

0

Small-scale

0.305

High

804620

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

804646

RS15
Small ribosomal subunit protein uS19

2

0

High-throughput

0.305

High

804612

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.292

High

544781

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.288

High

449411

SPT2
Protein SPT2

1

0

High-throughput

0.279

Low

721918

XPO1
Exportin-1

1

0

High-throughput

0.279

Low

804638

COPA
Coatomer subunit alpha

1

0

High-throughput

0.269

Low

804641

RN35
Large ribosomal subunit protein bL35m

1

0

High-throughput

0.269

Low

804688

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.269

Low

383305

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.249

Low

383689

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

503029

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

503788

RL27A
Large ribosomal subunit protein eL27A

1

0

Small-scale

0.249

Low

513362

RL23B
Large ribosomal subunit protein uL14B

1

0

Small-scale

0.249

Low

734965

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

739629

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

778316

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

802155

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

804107

RPP1
Ribonuclease P/MRP protein subunit RPP1

1

0

High-throughput

0.249

Low

804610

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

804628

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

804629

RL38
Large ribosomal subunit protein eL38

1

0

Small-scale

0.249

Low

804633

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

804643

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.249

Low

804645

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

804652

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

804657

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

804663

HRQ1
ATP-dependent helicase HRQ1

1

0

Small-scale

0.249

Low

804665

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

804671

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

444510

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.232

Low

450583

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.232

Low

510465

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low

645404

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.232

Low

676723

GBP2
Serine/arginine

1

0

High-throughput

0.232

Low

752227

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

804626

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

804631

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low

804691

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025