HitPredict

Interactor 1: IKZF1 (Q13422)
DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
Gene: IKZF1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	30760870, 12015313, 35583604, 10204490
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 519 Hs			1 488
+	Hs
		1033633 IKZF1_HUMAN (1-519): 0: 664: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177285 IKZF1_HUMAN (1-519): 0: 664: 100.00		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		1270517 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270436 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270518 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038804 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038805 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		936415 Q8C5P6_MOUSE (1-254): 8.48e-111: 331: 94.88		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Mm
		140300 Q8C5P6_MOUSE (1-254): 8.48e-111: 331: 94.88		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1033686 IKZF1_HUMAN (1-519): 0: 664: 100.00		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37
+	Hs
		1193248 ZSCA2_HUMAN (277-519): 8.68e-36: 142: 13.17		HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40
+	Hs
		1260190 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37
+	Hs
		1260200 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37