Protein: MK09
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)

Gene: MK09, MAPK9
Organism: Homo sapiens
Interactions: 171
UniProt ID: P45984

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004705 - JUN kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

853845

DUS16
Dual specificity protein phosphatase 16

8

20

Small-scale

0.970

High

853615

MK08
Mitogen-activated protein kinase 8

6

18

Small-scale

0.949

High

853875

DUS10
Dual specificity protein phosphatase 10

6

20

Small-scale

0.942

High

853765

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

6

20

Small-scale

0.940

High

853797

SF3B4
Splicing factor 3B subunit 4

4

12

High-throughput

0.911

High

853764

MK09
Mitogen-activated protein kinase 9

4

17

Small-scale

0.904

High

853786

DUS8
Dual specificity protein phosphatase 8

4

20

High-throughput

0.903

High

853843

RSLAB
Ras-like protein family member 10B

4

9

High-throughput

0.902

High

853841

LMBL3
Lethal(3)malignant brain tumor-like protein 3

3

3

High-throughput

0.871

High

362941

EGFR
Epidermal growth factor receptor

3

13

High-throughput

0.843

High

853785

DUS4
Dual specificity protein phosphatase 4

3

20

High-throughput

0.843

High

161961

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

3

20

Small-scale

0.820

High

853833

LRC15
Leucine-rich repeat-containing protein 15

3

0

High-throughput

0.816

High

703916

DUS1
Dual specificity protein phosphatase 1

2

20

Small-scale

0.776

High

853772

MK10
Mitogen-activated protein kinase 10

2

18

High-throughput

0.776

High

326677

DUS14
Dual specificity protein phosphatase 14

3

20

High-throughput

0.770

High

719297

MPIP3
M-phase inducer phosphatase 3

2

10

Small-scale

0.768

High

853787

M3K1
Mitogen-activated protein kinase kinase kinase 1

2

20

Small-scale

0.767

High

429478

JUN
Transcription factor Jun

19

20

Small-scale

0.767

High

583493

ATF2
Cyclic AMP-dependent transcription factor ATF-2

10

20

Small-scale

0.758

High

853771

ZN138
Zinc finger protein 138

2

0

High-throughput

0.742

High

853838

MCRS1
Microspherule protein 1

2

0

High-throughput

0.742

High

853844

ZN559
Zinc finger protein 559

2

0

High-throughput

0.742

High

214552

WDR62
WD repeat-containing protein 62

6

16

Small-scale

0.742

High

853870

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

5

9

Small-scale

0.726

High

732469

ARRB2
Beta-arrestin-2

5

9

High-throughput

0.724

High

853766

ARRB1
Beta-arrestin-1

5

9

High-throughput

0.722

High

853779

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

20

Small-scale

0.710

High

853829

LNX1
E3 ubiquitin-protein ligase LNX

4

14

High-throughput

0.705

High

853847

CEP44
Centrosomal protein of 44 kDa

4

1

High-throughput

0.705

High

664369

ZBT25
Zinc finger and BTB domain-containing protein 25

1

3

High-throughput

0.698

High

853868

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

10

High-throughput

0.698

High

760820

GLYC
Serine hydroxymethyltransferase, cytosolic

4

1

High-throughput

0.698

High

853769

MEOX1
Homeobox protein MOX-1

4

6

High-throughput

0.698

High

853777

SRSF2
Serine/arginine-rich splicing factor 2

1

12

High-throughput

0.691

High

853793

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

12

High-throughput

0.691

High

853821

STK40
Serine/threonine-protein kinase 40

1

14

High-throughput

0.691

High

413368

P53
Cellular tumor antigen p53

4

11

Small-scale

0.676

High

622421

ELK1
ETS domain-containing protein Elk-1

3

20

Small-scale

0.674

High

595339

H15
Histone H1.5

3

8

High-throughput

0.667

High

787618

SPB5
Serpin B5

3

4

High-throughput

0.667

High

853874

PKP3
Plakophilin-3

3

11

High-throughput

0.667

High

853826

DTX3
Probable E3 ubiquitin-protein ligase DTX3

4

0

High-throughput

0.663

High

853822

LNX2
Ligand of Numb protein X 2

3

14

High-throughput

0.658

High

853869

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

3

20

Small-scale

0.651

High

719197

MPIP2
M-phase inducer phosphatase 2

1

10

Small-scale

0.647

High

728096

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.647

High

853834

DUS19
Dual specificity protein phosphatase 19

1

20

Small-scale

0.647

High

853805

EFHC2
EF-hand domain-containing family member C2

4

11

High-throughput

0.637

High

244657

ZC3H1
Zinc finger C3H1 domain-containing protein

2

1

High-throughput

0.628

High

279300

TULP3
Tubby-related protein 3

2

5

High-throughput

0.628

High

853830

RHPN1
Rhophilin-1

2

8

High-throughput

0.628

High

853857

HXC10
Homeobox protein Hox-C10

2

7

High-throughput

0.628

High

241008

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.618

High

830297

CCNF
Cyclin-F

1

10

High-throughput

0.618

High

853767

KC1E
Casein kinase I isoform epsilon

1

14

High-throughput

0.618

High

853796

KPCD1
Serine/threonine-protein kinase D1

1

20

Small-scale

0.618

High

853850

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.618

High

853813

DSG4
Desmoglein-4

2

3

High-throughput

0.611

High

505088

BNIP5
Protein BNIP5

3

2

High-throughput

0.607

High

138648

IMA4
Importin subunit alpha-4

2

3

High-throughput

0.606

High

140168

SDCB1
Syntenin-1

2

15

High-throughput

0.606

High

192363

GSC2
Homeobox protein goosecoid-2

2

4

High-throughput

0.606

High

211629

ZNHI1
Zinc finger HIT domain-containing protein 1

2

2

High-throughput

0.606

High

221242

DCX
Neuronal migration protein doublecortin

2

1

High-throughput

0.606

High

570374

GFAP
Glial fibrillary acidic protein

2

7

High-throughput

0.606

High

789426

PPARG
Peroxisome proliferator-activated receptor gamma

2

17

High-throughput

0.606

High

853775

PO6F2
POU domain, class 6, transcription factor 2

2

2

High-throughput

0.606

High

853778

PAX5
Paired box protein Pax-5

2

2

High-throughput

0.606

High

853784

CDC16
Cell division cycle protein 16 homolog

2

4

High-throughput

0.606

High

853807

MLIP
Muscular LMNA-interacting protein

2

4

High-throughput

0.606

High

853825

CBLL2
E3 ubiquitin-protein ligase CBLL2

2

1

High-throughput

0.606

High

853846

PBX4
Pre-B-cell leukemia transcription factor 4

2

4

High-throughput

0.606

High

853859

KLHL8
Kelch-like protein 8

2

3

High-throughput

0.606

High

853861

LHX3
LIM/homeobox protein Lhx3

2

3

High-throughput

0.606

High

853871

LZTS1
Leucine zipper putative tumor suppressor 1

2

9

High-throughput

0.606

High

529292

TAU
Microtubule-associated protein tau

2

19

Small-scale

0.602

High

603625

JUNB
Transcription factor JunB

2

20

Small-scale

0.602

High

853774

GRB2
Growth factor receptor-bound protein 2

2

8

Small-scale

0.602

High

853795

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

13

Small-scale

0.602

High

144085

WNT7A
Protein Wnt-7a

2

0

High-throughput

0.602

High

853840

ZN414
Zinc finger protein 414

2

0

High-throughput

0.602

High

853776

PRKDC
DNA-dependent protein kinase catalytic subunit

2

6

Small-scale

0.595

High

764521

CTNB1
Catenin beta-1

1

9

Small-scale

0.586

High

853791

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

2

11

Small-scale

0.584

High

853788

CENPR
Centromere protein R

2

0

High-throughput

0.580

High

853831

TCP1L
T-complex protein 10A homolog 1

2

0

High-throughput

0.580

High

853848

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

853854

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

853770

TOB1
Protein Tob1

1

3

Small-scale

0.578

High

853811

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

853817

LRC56
Leucine-rich repeat-containing protein 56

2

2

High-throughput

0.574

High

853789

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.573

High

853790

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

12

Small-scale

0.561

High

853866

HDAC9
Histone deacetylase 9

1

13

Small-scale

0.561

High

827695

STAT3
Signal transducer and activator of transcription 3

1

8

Small-scale

0.554

High

853801

RSPO4
R-spondin-4

2

3

High-throughput

0.553

High

853814

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

9

High-throughput

0.553

High

853856

GOG6A
Golgin subfamily A member 6A

2

9

High-throughput

0.553

High

853853

XPP1
Xaa-Pro aminopeptidase 1

1

3

High-throughput

0.541

High

853864

XPO7
Exportin-7

1

2

High-throughput

0.541

High

605059

JUND
Transcription factor JunD

1

20

Small-scale

0.536

High

299747

MPDZ
Multiple PDZ domain protein

1

14

High-throughput

0.536

High

391584

FRIH
Ferritin heavy chain

1

1

High-throughput

0.536

High

853794

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.536

High

567205

PPA5
Tartrate-resistant acid phosphatase type 5

1

0

High-throughput

0.518

High

853860

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.518

High

353850

BCL10
B-cell lymphoma/leukemia 10

1

1

Small-scale

0.515

High

853855

PP14D
Protein phosphatase 1 regulatory subunit 14D

1

0

High-throughput

0.513

High

239414

3BP5
SH3 domain-binding protein 5

1

2

Small-scale

0.501

High

572787

NCF1
Neutrophil cytosol factor 1

1

7

Small-scale

0.501

High

840017

CASP3
Caspase-3

1

11

Small-scale

0.501

High

853780

B2CL1
Bcl-2-like protein 1

1

13

Small-scale

0.501

High

853836

JDP2
Jun dimerization protein 2

1

20

Small-scale

0.501

High

853873

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

819

A0A096LNW4
PRAME family member 9

1

1

High-throughput

0.489

High

60637

CI170
Uncharacterized protein encoded by LINC02872

1

1

High-throughput

0.489

High

673758

LAMA1
Laminin subunit alpha-1

1

1

High-throughput

0.489

High

853806

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

5

High-throughput

0.489

High

853827

F110D
Protein FAM110D

1

1

High-throughput

0.489

High

853863

CS025
UPF0449 protein C19orf25

1

2

High-throughput

0.489

High

853865

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.489

High

853867

AT7L1
Ataxin-7-like protein 1

1

3

High-throughput

0.489

High

699641

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

2

Small-scale

0.484

High

533618

CLUS
Clusterin

1

1

High-throughput

0.481

High

853782

LMAN2
Vesicular integral-membrane protein VIP36

1

1

High-throughput

0.481

High

853783

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

12

Small-scale

0.481

High

853852

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

1

High-throughput

0.481

High

853872

FBW1A
F-box/WD repeat-containing protein 1A

1

14

Small-scale

0.481

High

853768

PSN1
Presenilin-1

1

0

Small-scale

0.480

High

853837

NICA
Nicastrin

1

0

Small-scale

0.480

High

184055

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

1

High-throughput

0.479

High

370596

FOS
Protein c-Fos

1

20

High-throughput

0.479

High

597864

LYAM2
E-selectin

1

2

Small-scale

0.479

High

697033

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

Small-scale

0.479

High

767626

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

853773

SEC13
Protein SEC13 homolog

1

5

High-throughput

0.479

High

853792

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.479

High

853799

NF2L2
Nuclear factor erythroid 2-related factor 2

1

20

Small-scale

0.479

High

853800

NFE2
Transcription factor NF-E2 45 kDa subunit

1

20

Small-scale

0.479

High

853808

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

853820

AHI1
Jouberin

1

16

High-throughput

0.479

High

853828

RIN3
Ras and Rab interactor 3

1

9

High-throughput

0.479

High

853832

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

8

Small-scale

0.479

High

853835

STAB2
Stabilin-2

1

7

Small-scale

0.479

High

853842

SCLT1
Sodium channel and clathrin linker 1

1

6

High-throughput

0.479

High

853849

CDT1
DNA replication factor Cdt1

1

2

Small-scale

0.479

High

853851

DHX33
ATP-dependent RNA helicase DHX33

1

1

High-throughput

0.479

High

853858

WWOX
WW domain-containing oxidoreductase

1

3

Small-scale

0.479

High

853862

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

9

Small-scale

0.479

High

853803

NHSL2
NHS-like protein 2

1

3

High-throughput

0.470

High

296692

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.460

High

326531

MFN2
Mitofusin-2

1

0

Small-scale

0.458

High

853798

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

853823

SIM20
Small integral membrane protein 20

1

0

High-throughput

0.458

High

853781

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

13

Small-scale

0.445

High

105520

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

853810

FBX42
F-box only protein 42

1

4

High-throughput

0.437

High

60648

SMCO3
Single-pass membrane and coiled-coil domain-containing protein 3

3

0

High-throughput

0.352

High

853816

TEX11
Testis-expressed protein 11

3

0

High-throughput

0.352

High

853812

CE024
UPF0461 protein C5orf24

2

0

High-throughput

0.328

High

853839

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.328

High

339195

CA105
Uncharacterized protein C1orf105

2

0

High-throughput

0.316

High

853802

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

853815

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.316

High

853818

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

853809

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.299

High

853804

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

853819

FAM9C
Protein FAM9C

1

0

High-throughput

0.279

Low

853824

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025