HitPredict

Interactor 1: TMED1 (Q13445)
Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1)
Gene: TMED1

Interactor 2: SPP2B (Q8TCT7)
Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)
Gene: SPPL2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 227 Hs			1 592
+	Hs
		1253878 TMED9_HUMAN (14-225): 3.54e-69: 213: 16.81		SPP2B_HUMAN (25-592): 0: 704: 100.00
+	Hs
		1071800 TMED2_HUMAN (32-225): 3.29e-69: 212: 22.17		SPP2B_HUMAN (25-592): 0: 704: 100.00
+	Hs
		1192841 TMED4_HUMAN (27-225): 4.41e-67: 208: 17.84		SPP2B_HUMAN (25-592): 0: 704: 100.00
+	Hs
		1253929 TMED3_HUMAN (30-225): 9.47e-65: 201: 31.12		SPP2B_HUMAN (25-592): 0: 704: 100.00
+	Hs
		833278 TMEDA_HUMAN (31-226): 1.71e-56: 180: 19.90		SPPL3_HUMAN (162-509): 3.71e-104: 321: 23.76
+	Sc
		711134 ERP4_YEAST (18-224): 3.99e-55: 176: 19.91		YKK0_YEAST (296-500): 2.31e-54: 196: 29.09
+	Sc
		711109 ERP2_YEAST (35-224): 3.27e-50: 164: 23.83		YKK0_YEAST (296-500): 2.31e-54: 196: 29.09