Protein: NAAA
N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.60) (Acid ceramidase-like protein) (Acylsphingosine deacylase NAAA) (EC 3.5.1.23) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta]

Gene: NAAA
Organism: Homo sapiens
Interactions: 220
UniProt ID: Q02083

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0006631 - fatty acid metabolic process
GO:0006670 - sphingosine metabolic process
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

249040

NRP2
Neuropilin-2

3

2

High-throughput

0.667

High

565354

ITA4
Integrin alpha-4

3

3

High-throughput

0.667

High

586372

ARSB
Arylsulfatase B

3

7

High-throughput

0.667

High

756543

GALNS
N-acetylgalactosamine-6-sulfatase

3

6

High-throughput

0.667

High

1034738

TBB8
Tubulin beta-8 chain

3

3

High-throughput

0.667

High

1034760

ARSK
Arylsulfatase K

3

6

High-throughput

0.667

High

1034815

CNTP3
Contactin-associated protein-like 3

3

2

High-throughput

0.667

High

1034842

CEIP2
Cell surface hyaluronidase CEMIP2

3

1

High-throughput

0.667

High

1034851

MA2B2
Epididymis-specific alpha-mannosidase

3

2

High-throughput

0.667

High

253759

UGDH
UDP-glucose 6-dehydrogenase

3

0

High-throughput

0.638

High

932360

ANAG
Alpha-N-acetylglucosaminidase

3

0

High-throughput

0.638

High

1034736

T132A
Transmembrane protein 132A

3

0

High-throughput

0.638

High

1034766

SYVN1
E3 ubiquitin-protein ligase synoviolin

3

0

High-throughput

0.638

High

1034843

NB5R1
NADH-cytochrome b5 reductase 1

3

0

High-throughput

0.638

High

448016

ITAV
Integrin alpha-V

2

3

High-throughput

0.628

High

996912

TBA4A
Tubulin alpha-4A chain

2

3

High-throughput

0.628

High

907211

SPHM
N-sulphoglucosamine sulphohydrolase

2

6

High-throughput

0.611

High

1034762

TBA1A
Tubulin alpha-1A chain

2

3

High-throughput

0.611

High

1034813

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

2

2

High-throughput

0.611

High

896367

ERF
ETS domain-containing transcription factor ERF

3

1

High-throughput

0.609

High

1034727

OS9
Protein OS-9

3

1

High-throughput

0.609

High

1034776

PGLT1
Protein O-glucosyltransferase 1

3

2

High-throughput

0.609

High

1034789

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

3

2

High-throughput

0.609

High

1034792

PCSK5
Proprotein convertase subtilisin/kexin type 5

3

1

High-throughput

0.609

High

1034805

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

3

5

High-throughput

0.609

High

1034795

TTC17
Tetratricopeptide repeat protein 17

2

0

High-throughput

0.585

High

1034823

SIAE
Sialate O-acetylesterase

2

0

High-throughput

0.585

High

1034824

S38AA
Solute carrier family 38 member 10

2

0

High-throughput

0.585

High

1034771

SULF2
Extracellular sulfatase Sulf-2

2

6

High-throughput

0.558

High

62940

POTEF
POTE ankyrin domain family member F

1

1

High-throughput

0.536

High

211915

SPIT1
Kunitz-type protease inhibitor 1

1

1

High-throughput

0.536

High

224479

PI15
Peptidase inhibitor 15

1

1

High-throughput

0.536

High

292116

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

4

High-throughput

0.536

High

380625

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

2

High-throughput

0.536

High

408027

TBB4A
Tubulin beta-4A chain

1

3

High-throughput

0.536

High

427877

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.536

High

452090

PROS
Vitamin K-dependent protein S

1

1

High-throughput

0.536

High

457374

TBB5
Tubulin beta chain

1

3

High-throughput

0.536

High

520815

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.536

High

534950

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

548484

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.536

High

551990

ADT1
ADP/ATP translocase 1

1

2

High-throughput

0.536

High

552202

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.536

High

565600

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.536

High

582323

ARSA
Arylsulfatase A

1

6

High-throughput

0.536

High

647346

IDS
Iduronate 2-sulfatase

1

6

High-throughput

0.536

High

719710

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

2

High-throughput

0.536

High

1023330

AT2C1
Calcium-transporting ATPase type 2C member 1

1

1

High-throughput

0.536

High

1024331

S25A3
Solute carrier family 25 member 3

1

6

High-throughput

0.536

High

1030151

IL5RA
Interleukin-5 receptor subunit alpha

1

1

High-throughput

0.536

High

1034723

MFGM
Lactadherin

1

4

High-throughput

0.536

High

1034728

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.536

High

1034731

DPOD3
DNA polymerase delta subunit 3

1

1

High-throughput

0.536

High

1034737

TECT1
Tectonic-1

1

1

High-throughput

0.536

High

1034748

GP107
Protein GPR107

1

1

High-throughput

0.536

High

1034751

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

1

High-throughput

0.536

High

1034756

POTEE
POTE ankyrin domain family member E

1

1

High-throughput

0.536

High

1034788

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

1

High-throughput

0.536

High

1034807

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.536

High

1034810

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.536

High

1034819

TBB1
Tubulin beta-1 chain

1

4

High-throughput

0.536

High

1034832

PYRG2
CTP synthase 2

1

1

High-throughput

0.536

High

1034846

FBX2
F-box only protein 2

1

2

High-throughput

0.536

High

1034847

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

2

High-throughput

0.536

High

1034856

ORNT1
Mitochondrial ornithine transporter 1

1

6

High-throughput

0.536

High

133488

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

161021

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

0

High-throughput

0.513

High

162189

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.513

High

166901

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.513

High

212947

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.513

High

254283

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

1

0

High-throughput

0.513

High

257824

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.513

High

276957

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

High-throughput

0.513

High

341413

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.513

High

547134

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.513

High

567833

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.513

High

592641

ITB4
Integrin beta-4

1

0

High-throughput

0.513

High

600605

NAGAB
Alpha-N-acetylgalactosaminidase

1

0

High-throughput

0.513

High

663357

KTHY
Thymidylate kinase

1

0

High-throughput

0.513

High

684490

CTNA2
Catenin alpha-2

1

0

High-throughput

0.513

High

755474

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.513

High

771660

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.513

High

889968

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

905543

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

1022381

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.513

High

1029801

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.513

High

1034721

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.513

High

1034724

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

0

High-throughput

0.513

High

1034732

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

1034741

OCAD2
OCIA domain-containing protein 2

1

0

High-throughput

0.513

High

1034749

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

0

High-throughput

0.513

High

1034750

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.513

High

1034752

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.513

High

1034759

ENPP7
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

1

0

High-throughput

0.513

High

1034761

NFXL1
NF-X1-type zinc finger protein NFXL1

1

0

High-throughput

0.513

High

1034763

RD3
Protein RD3

1

0

High-throughput

0.513

High

1034765

AGRG6
Adhesion G-protein coupled receptor G6

1

0

High-throughput

0.513

High

1034773

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

0

High-throughput

0.513

High

1034775

SUMF1
Formylglycine-generating enzyme

1

0

High-throughput

0.513

High

1034779

NLGN2
Neuroligin-2

1

0

High-throughput

0.513

High

1034786

TM263
Transmembrane protein 263

1

0

High-throughput

0.513

High

1034791

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1034794

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1034797

RUSF1
RUS family member 1

1

0

High-throughput

0.513

High

1034800

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.513

High

1034803

F210A
Protein FAM210A

1

0

High-throughput

0.513

High

1034806

TM209
Transmembrane protein 209

1

0

High-throughput

0.513

High

1034808

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.513

High

1034809

PKP2
Plakophilin-2

1

0

High-throughput

0.513

High

1034816

LMA2L
VIP36-like protein

1

0

High-throughput

0.513

High

1034822

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1034826

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

1034827

SEC12
Guanine nucleotide-exchange factor SEC12

1

0

High-throughput

0.513

High

1034835

DJB12
DnaJ homolog subfamily B member 12

1

0

High-throughput

0.513

High

1034837

CHPF2
Chondroitin sulfate glucuronyltransferase

1

0

High-throughput

0.513

High

1034841

SUSD2
Sushi domain-containing protein 2

1

0

High-throughput

0.513

High

1034848

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.513

High

1034849

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.513

High

1034853

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.513

High

1034854

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.513

High

1034857

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.513

High

1034859

S23IP
SEC23-interacting protein

1

0

High-throughput

0.513

High

421947

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

597796

CRIS2
Cysteine-rich secretory protein 2

1

1

High-throughput

0.489

High

603775

ITA2
Integrin alpha-2

1

3

High-throughput

0.489

High

832510

ETV3
ETS translocation variant 3

1

1

High-throughput

0.489

High

885465

MA2A2
Alpha-mannosidase 2x

1

2

High-throughput

0.489

High

1034720

BDH
D-beta-hydroxybutyrate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1034729

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

3

High-throughput

0.489

High

1034730

MBTP1
Membrane-bound transcription factor site-1 protease

1

1

High-throughput

0.489

High

1034753

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

4

High-throughput

0.489

High

1034754

SFXN4
Sideroflexin-4

1

2

High-throughput

0.489

High

1034757

PLGT2
Protein O-glucosyltransferase 2

1

2

High-throughput

0.489

High

1034764

PLGT3
Protein O-glucosyltransferase 3

1

2

High-throughput

0.489

High

1034774

S2529
Mitochondrial basic amino acids transporter

1

5

High-throughput

0.489

High

1034777

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.489

High

1034783

S2540
Mitochondrial glutathione transporter SLC25A40

1

5

High-throughput

0.489

High

1034796

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.489

High

1034802

SFXN2
Sideroflexin-2

1

2

High-throughput

0.489

High

1034814

SFXN3
Sideroflexin-3

1

2

High-throughput

0.489

High

1034825

TPC
Mitochondrial thiamine pyrophosphate carrier

1

4

High-throughput

0.489

High

1034834

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.489

High

1034840

DIC
Mitochondrial dicarboxylate carrier

1

4

High-throughput

0.489

High

1034844

BTNL2
Butyrophilin-like protein 2

1

1

High-throughput

0.489

High

1034850

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

1

High-throughput

0.489

High

1034735

MA2A1
Alpha-mannosidase 2

1

2

High-throughput

0.479

High

1034798

TECT2
Tectonic-2

1

1

High-throughput

0.479

High

1034831

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

284391

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

High-throughput

0.458

High

774299

BASI
Basigin

1

0

High-throughput

0.458

High

1034755

WDR73
Integrator complex assembly factor WDR73

1

0

High-throughput

0.458

High

1034785

SCRB1
Scavenger receptor class B member 1

1

0

High-throughput

0.458

High

1034830

CHSTC
Carbohydrate sulfotransferase 12

1

0

High-throughput

0.458

High

409355

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.445

High

1034804

CNT3B
Contactin-associated protein-like 3B

1

2

High-throughput

0.445

High

218074

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

222263

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

611721

BMP7
Bone morphogenetic protein 7

3

0

High-throughput

0.347

High

914840

NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

3

0

High-throughput

0.347

High

1034733

EXT1
Exostosin-1

3

0

High-throughput

0.347

High

1034739

OFUT4
GDP-fucose protein O-fucosyltransferase 4

3

0

High-throughput

0.347

High

1034747

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

3

0

High-throughput

0.347

High

1034767

OAF
Out at first protein homolog

3

0

High-throughput

0.347

High

277008

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

2

0

High-throughput

0.318

High

327106

NXPH4
Neurexophilin-4

2

0

High-throughput

0.318

High

933997

PLTP
Phospholipid transfer protein

2

0

High-throughput

0.318

High

124312

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

158987

ZN195
Zinc finger protein 195

1

0

High-throughput

0.279

Low

282834

CRLF1
Cytokine receptor-like factor 1

1

0

High-throughput

0.279

Low

342541

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

388708

C1QB
Complement C1q subcomponent subunit B

1

0

High-throughput

0.279

Low

416607

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.279

Low

426072

PPB1
Alkaline phosphatase, placental type

1

0

High-throughput

0.279

Low

570662

EDN3
Endothelin-3

1

0

High-throughput

0.279

Low

894463

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

935714

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.279

Low

943037

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

1012167

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.279

Low

1034722

RON
Macrophage-stimulating protein receptor

1

0

High-throughput

0.279

Low

1034725

SEM3B
Semaphorin-3B

1

0

High-throughput

0.279

Low

1034726

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1034734

TAZ
Tafazzin

1

0

High-throughput

0.279

Low

1034740

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

0

High-throughput

0.279

Low

1034742

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

0

High-throughput

0.279

Low

1034744

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.279

Low

1034745

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1034746

GT253
Inactive glycosyltransferase 25 family member 3

1

0

High-throughput

0.279

Low

1034758

LYZL1
Lysozyme-like protein 1

1

0

High-throughput

0.279

Low

1034768

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.279

Low

1034770

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

1034772

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

0

High-throughput

0.279

Low

1034780

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.279

Low

1034781

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.279

Low

1034782

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.279

Low

1034787

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.279

Low

1034793

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1034799

KIRR1
Kin of IRRE-like protein 1

1

0

High-throughput

0.279

Low

1034801

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.279

Low

1034811

MIC25
MICOS complex subunit MIC25

1

0

High-throughput

0.279

Low

1034812

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

0

High-throughput

0.279

Low

1034817

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.279

Low

1034818

KLK15
Kallikrein-15

1

0

High-throughput

0.279

Low

1034820

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

1034821

ANTR1
Anthrax toxin receptor 1

1

0

High-throughput

0.279

Low

1034828

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

1034829

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.279

Low

1034833

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.279

Low

1034836

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.279

Low

1034838

FA8A1
Protein FAM8A1

1

0

High-throughput

0.279

Low

1034839

SE1L1
Protein sel-1 homolog 1

1

0

High-throughput

0.279

Low

1034845

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.279

Low

1034852

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.279

Low

1034855

LIPG
Endothelial lipase

1

0

High-throughput

0.279

Low

1034858

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.279

Low

319094

SC24D
Protein transport protein Sec24D

1

0

High-throughput

0.249

Low

1034743

NHLC3
NHL repeat-containing protein 3

1

0

High-throughput

0.249

Low

1034769

GLBL2
Beta-galactosidase-1-like protein 2

1

0

High-throughput

0.249

Low

1034778

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.249

Low

1034784

ZN507
Zinc finger protein 507

1

0

High-throughput

0.249

Low

1034790

SC65
Endoplasmic reticulum protein SC65

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025