Protein: ATG5
Autophagy protein 5 (APG5-like) (Apoptosis-specific protein)

Gene: ATG5
Organism: Homo sapiens
Interactions: 199
UniProt ID: Q9H1Y0

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000423 - mitophagy
GO:0001974 - blood vessel remodeling
GO:0002718 - regulation of cytokine production involved in immune response
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

296761

ATG12
Ubiquitin-like protein ATG12

10

3

Small-scale

0.975

High

1146827

A16L1
Autophagy-related protein 16-1

26

6

Small-scale

0.769

High

1328908

ATG3
Ubiquitin-like-conjugating enzyme ATG3

7

4

Small-scale

0.749

High

1191976

TCPR1
Tectonin beta-propeller repeat-containing protein 1

8

0

Small-scale

0.723

High

1239056

A16L2
Protein Atg16l2

5

6

Small-scale

0.719

High

1328920

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

5

4

Small-scale

0.714

High

1254504

CCHCR
Coiled-coil alpha-helical rod protein 1

5

2

High-throughput

0.705

High

1049327

KEAP1
Kelch-like ECH-associated protein 1

4

1

High-throughput

0.683

High

1255689

RBCC1
RB1-inducible coiled-coil protein 1

3

3

Small-scale

0.667

High

1328386

ATG10
Ubiquitin-like-conjugating enzyme ATG10

3

4

Small-scale

0.658

High

1326139

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

2

9

High-throughput

0.639

High

1287378

OPTN
Optineurin

2

3

Small-scale

0.629

High

1262199

TEKT4
Tektin-4

4

1

High-throughput

0.623

High

1327298

RB33B
Ras-related protein Rab-33B

2

3

Small-scale

0.619

High

60965

PSB11
Proteasome subunit beta type-11

2

5

High-throughput

0.606

High

1118359

GRAP1
GRIP1-associated protein 1

2

2

High-throughput

0.606

High

1289552

HOOK2
Protein Hook homolog 2

2

3

High-throughput

0.606

High

1328921

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

2

2

High-throughput

0.606

High

1224702

WDFY3
WD repeat and FYVE domain-containing protein 3

1

1

Small-scale

0.602

High

456645

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

2

1

High-throughput

0.601

High

347865

MYC
Myc proto-oncogene protein

2

0

Small-scale

0.598

High

1036894

SQSTM
Sequestosome-1

2

0

Small-scale

0.598

High

1026648

FADD
FAS-associated death domain protein

1

4

Small-scale

0.586

High

156355

PSA7
Proteasome subunit alpha type-7

2

3

Small-scale

0.584

High

1190087

MAVS
Mitochondrial antiviral-signaling protein

2

2

Small-scale

0.583

High

1012347

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1328922

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.580

High

875306

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.576

High

255202

ATG13
Autophagy-related protein 13

2

0

Small-scale

0.576

High

1328905

ATG5
Autophagy protein 5

1

1

High-throughput

0.575

High

427923

CAN1
Calpain-1 catalytic subunit

1

1

Small-scale

0.569

High

569011

CAN2
Calpain-2 catalytic subunit

1

1

Small-scale

0.569

High

321934

RIGI
Antiviral innate immune response receptor RIG-I

1

1

Small-scale

0.569

High

929655

RACK1
Small ribosomal subunit protein RACK1

1

1

Small-scale

0.561

High

632398

TNR6
Tumor necrosis factor receptor superfamily member 6

2

0

Small-scale

0.559

High

1048033

RB33A
Ras-related protein Rab-33A

2

4

Small-scale

0.558

High

1273577

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

Small-scale

0.554

High

1022450

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.541

High

585064

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.537

High

886383

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

Small-scale

0.537

High

262318

ULK1
Serine/threonine-protein kinase ULK1

1

2

Small-scale

0.536

High

280918

KRT37
Keratin, type I cuticular Ha7

1

1

High-throughput

0.536

High

281061

KRT38
Keratin, type I cuticular Ha8

1

1

High-throughput

0.536

High

943479

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.536

High

1189653

K1C27
Keratin, type I cytoskeletal 27

1

2

High-throughput

0.536

High

1315802

MLP3C
Microtubule-associated proteins 1A/1B light chain 3C

1

9

High-throughput

0.536

High

49668

IRGM
Immunity-related GTPase family M protein

1

0

Small-scale

0.529

High

306313

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

9

High-throughput

0.527

High

1289432

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.515

High

1221397

Q8IXW7
FMR1 protein

1

1

High-throughput

0.515

High

666965

TKT
Transketolase

1

0

High-throughput

0.513

High

719610

MERL
Merlin

1

0

High-throughput

0.513

High

791970

HD
Huntingtin

1

0

Small-scale

0.513

High

1146491

KAZRN
Kazrin

1

0

High-throughput

0.513

High

1174420

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.513

High

1184470

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1283637

EXOC4
Exocyst complex component 4

1

0

Small-scale

0.513

High

1284804

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1306676

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.513

High

1310981

ATGA1
Autophagy-related protein 101

1

0

Small-scale

0.513

High

609529

FGFR3
Fibroblast growth factor receptor 3

1

1

Small-scale

0.512

High

175199

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

1025552

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

Small-scale

0.501

High

1317603

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

1

Small-scale

0.500

High

992130

B2CL1
Bcl-2-like protein 1

1

0

Small-scale

0.493

High

1056980

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.489

High

838265

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

989117

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.481

High

163264

XPO1
Exportin-1

1

1

High-throughput

0.479

High

234991

SNX3
Sorting nexin-3

1

1

High-throughput

0.479

High

334287

LDHA
L-lactate dehydrogenase A chain

1

1

High-throughput

0.479

High

416512

S10A9
Protein S100-A9

1

1

High-throughput

0.479

High

508189

FGFR1
Fibroblast growth factor receptor 1

1

1

High-throughput

0.479

High

567259

CXA1
Gap junction alpha-1 protein

1

2

Small-scale

0.479

High

596320

FILA
Filaggrin

1

1

High-throughput

0.479

High

637552

PSA1
Proteasome subunit alpha type-1

1

2

High-throughput

0.479

High

637742

PSA2
Proteasome subunit alpha type-2

1

3

High-throughput

0.479

High

638006

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.479

High

656775

PSB5
Proteasome subunit beta type-5

1

3

Small-scale

0.479

High

741911

TAGL2
Transgelin-2

1

1

High-throughput

0.479

High

776816

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.479

High

786427

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

High-throughput

0.479

High

790876

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.479

High

845234

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

891317

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

9

High-throughput

0.479

High

906921

PRS4
26S proteasome regulatory subunit 4

1

1

High-throughput

0.479

High

994332

DHX9
ATP-dependent RNA helicase A

1

1

High-throughput

0.479

High

1031832

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

3

High-throughput

0.479

High

1038319

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

Small-scale

0.479

High

1043751

ASPP2
Apoptosis-stimulating of p53 protein 2

1

2

Small-scale

0.479

High

1173714

VP13C
Intermembrane lipid transfer protein VPS13C

1

1

High-throughput

0.479

High

1201009

LUZP1
Leucine zipper protein 1

1

2

High-throughput

0.479

High

1260092

IASPP
RelA-associated inhibitor

1

2

Small-scale

0.479

High

1284734

TTC28
Tetratricopeptide repeat protein 28

1

2

High-throughput

0.479

High

1286029

ATG2B
Autophagy-related protein 2 homolog B

1

1

High-throughput

0.479

High

1305819

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.479

High

1328026

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

9

High-throughput

0.479

High

1328912

BSN
Protein bassoon

1

2

Small-scale

0.479

High

123716

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.458

High

177721

BIRC5
Baculoviral IAP repeat-containing protein 5

1

0

Small-scale

0.458

High

182206

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

0

Small-scale

0.458

High

228660

PRKN
E3 ubiquitin-protein ligase parkin

1

0

Small-scale

0.458

High

276213

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

0

Small-scale

0.458

High

330285

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.458

High

337127

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.458

High

340527

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

360403

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

376010

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

382522

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.458

High

398092

ISG15
Ubiquitin-like protein ISG15

1

0

High-throughput

0.458

High

423357

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.458

High

430336

PROF1
Profilin-1

1

0

High-throughput

0.458

High

518765

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.458

High

535931

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

597544

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.458

High

597775

CSRP1
Cysteine and glycine-rich protein 1

1

0

High-throughput

0.458

High

603237

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.458

High

616078

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

621276

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

High-throughput

0.458

High

623173

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.458

High

671590

KCY
UMP-CMP kinase

1

0

High-throughput

0.458

High

690122

GBP1
Guanylate-binding protein 1

1

0

High-throughput

0.458

High

727190

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.458

High

739832

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.458

High

760306

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

809166

UTRN
Utrophin

1

0

High-throughput

0.458

High

838684

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.458

High

857212

CAZA1
F-actin-capping protein subunit alpha-1

1

0

High-throughput

0.458

High

868735

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

876891

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.458

High

899033

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.458

High

901425

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

908146

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.458

High

915076

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.458

High

916372

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

917910

H4
Histone H4

1

0

High-throughput

0.458

High

964960

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

973232

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.458

High

975018

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

976761

TAP1
Antigen peptide transporter 1

1

0

High-throughput

0.458

High

990931

ZO1
Tight junction protein ZO-1

1

0

High-throughput

0.458

High

997901

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.458

High

1026225

PAK1
Serine/threonine-protein kinase PAK 1

1

0

High-throughput

0.458

High

1031272

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

1075587

TSN
Translin

1

0

High-throughput

0.458

High

1079599

NEDD8
NEDD8

1

0

High-throughput

0.458

High

1116853

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.458

High

1122079

Q53Y06
V-type proton ATPase subunit E 1

1

0

High-throughput

0.458

High

1144504

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.458

High

1164704

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

1187772

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

High-throughput

0.458

High

1216085

RHPN2
Rhophilin-2

1

0

High-throughput

0.458

High

1281382

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1284064

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1291574

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.458

High

1306775

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.458

High

1314567

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

0

High-throughput

0.458

High

1315496

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

Small-scale

0.458

High

1328907

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

1328909

RCC2
Protein RCC2

1

0

High-throughput

0.458

High

1328910

DAPK2
Death-associated protein kinase 2

1

0

Small-scale

0.458

High

1328914

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

1328915

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.458

High

1328918

ORN
Oligoribonuclease, mitochondrial

1

0

High-throughput

0.458

High

777471

MDHC
Malate dehydrogenase, cytoplasmic

1

1

High-throughput

0.445

High

1073411

CNN3
Calponin-3

1

1

High-throughput

0.445

High

1089453

Q17RG0
ATG16L1 protein

1

6

High-throughput

0.445

High

1328917

SHLB1
Endophilin-B1

1

1

High-throughput

0.445

High

1243747

PPHLN
Periphilin-1

1

0

Small-scale

0.438

High

195547

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.437

High

434854

CXB1
Gap junction beta-1 protein

1

2

Small-scale

0.437

High

661185

CXB2
Gap junction beta-2 protein

1

2

Small-scale

0.437

High

742526

SYUA
Alpha-synuclein

1

0

Small-scale

0.426

High

1054198

BECN1
Beclin-1

1

0

High-throughput

0.426

High

1252122

PUM2
Pumilio homolog 2

1

0

High-throughput

0.426

High

1263123

EDAD
Ectodysplasin-A receptor-associated adapter protein

1

0

High-throughput

0.426

High

506475

RALB
Ras-related protein Ral-B

1

1

Small-scale

0.407

High

1260020

CCD12
Coiled-coil domain-containing protein 12

4

0

High-throughput

0.359

High

1198319

K1328
Protein hinderin

2

0

High-throughput

0.316

High

1229570

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

1309429

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.279

Low

337252

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.249

Low

495755

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

Small-scale

0.249

Low

533539

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

671117

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.249

Low

671517

ECHM
Enoyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.249

Low

879716

ATPK
ATP synthase subunit f, mitochondrial

1

0

High-throughput

0.249

Low

1269586

ESR2
Estrogen receptor beta

1

0

Small-scale

0.249

Low

1287619

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

High-throughput

0.249

Low

1328911

STML2
Stomatin-like protein 2, mitochondrial

1

0

High-throughput

0.249

Low

1328913

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.249

Low

1328916

PLAK2
PALM2-AKAP2 fusion protein

1

0

High-throughput

0.249

Low

1328919

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.249

Low

129942

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

0

High-throughput

0.232

Low

353176

KV105
Immunoglobulin kappa variable 1-5

1

0

High-throughput

0.232

Low

354126

IGHA1
Immunoglobulin heavy constant alpha 1

1

0

High-throughput

0.232

Low

1074994

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.232

Low

1328906

PCD18
Protocadherin-18

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024