HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: TSSK1 (Q9BXA7)
Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A)
Gene: TSSK1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 367
+	Hs
		1034972 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		TSSK2_HUMAN (1-352): 3.05e-145: 416: 68.27
+	Hs
		682173 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT2_HUMAN (4-352): 1.83e-136: 399: 25.92
+	Hs
		1035058 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT3_HUMAN (4-352): 7.69e-136: 397: 25.49
+	Hs
		681830 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT1_HUMAN (4-349): 6.92e-135: 395: 26.35
+	Hs
		972568 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		TSSK2_HUMAN (1-352): 3.05e-145: 416: 68.27
+	Hs
		1035034 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KS6B2_HUMAN (4-366): 6.4e-133: 390: 23.32
+	Hs
		972577 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		TSSK1_HUMAN (1-367): 1.04e-136: 395: 100.00
+	Hs
		1034987 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		TSSK6_HUMAN (1-278): 2.93e-79: 245: 46.24
+	Hs
		1035062 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		SIK3_HUMAN (12-273): 2.18e-53: 191: 40.91
+	Hs
		118785 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		TSSK1_HUMAN (1-367): 1.04e-136: 395: 100.00
+	Hs
		684963 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		TSSK2_HUMAN (1-352): 3.05e-145: 416: 68.27
+	Hs
		1053243 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		KS6B2_HUMAN (4-366): 6.4e-133: 390: 23.32
+	Hs
		684999 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		TSSK1_HUMAN (1-367): 1.04e-136: 395: 100.00
+	Rn
		193486 STIP1_RAT (265-457): 1.25e-22: 102: 18.14		AKT3_RAT (4-352): 6.58e-134: 392: 25.49
+	Hs
		118784 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		TSSK6_HUMAN (1-278): 2.93e-79: 245: 46.24
+	Hs
		685124 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		SIK3_HUMAN (12-273): 2.18e-53: 191: 40.91