Protein: ECHM
Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH)

Gene: ECHM, ECHS1
Organism: Homo sapiens
Interactions: 201
UniProt ID: P30084

Gene Ontology (top 5):
GO:0004165 - delta(3)-delta(2)-enoyl-CoA isomerase activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006635 - fatty acid beta-oxidation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

539292

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

3

6

High-throughput

0.667

High

717097

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

6

Small-scale

0.656

High

717114

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

3

0

High-throughput

0.638

High

717035

ECHM
Enoyl-CoA hydratase, mitochondrial

1

15

High-throughput

0.621

High

717080

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

16

High-throughput

0.618

High

717036

LONM
Lon protease homolog, mitochondrial

2

4

High-throughput

0.611

High

717091

HERC1
Probable E3 ubiquitin-protein ligase HERC1

3

11

High-throughput

0.609

High

717094

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

5

High-throughput

0.602

High

279665

CISY
Citrate synthase, mitochondrial

2

8

High-throughput

0.584

High

400346

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

4

High-throughput

0.584

High

559877

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

3

High-throughput

0.584

High

717074

GRSF1
G-rich sequence factor 1

2

4

High-throughput

0.584

High

717075

TRAP1
Heat shock protein 75 kDa, mitochondrial

2

6

High-throughput

0.584

High

717093

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

5

High-throughput

0.584

High

717186

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

3

Small-scale

0.584

High

717168

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

5

Small-scale

0.561

High

717079

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

3

High-throughput

0.558

High

717084

CUL7
Cullin-7

2

7

High-throughput

0.558

High

484396

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

647483

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

High-throughput

0.518

High

717121

KAT2A
Histone acetyltransferase KAT2A

1

6

Small-scale

0.512

High

425995

CP2E1
Cytochrome P450 2E1

1

1

High-throughput

0.494

High

717050

FXR1
RNA-binding protein FXR1

1

5

High-throughput

0.494

High

717051

FXR2
RNA-binding protein FXR2

1

5

High-throughput

0.494

High

213828

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.489

High

340297

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.489

High

717068

KPCZ
Protein kinase C zeta type

1

6

High-throughput

0.489

High

717110

CUL9
Cullin-9

1

7

High-throughput

0.489

High

717117

NEDD1
Protein NEDD1

1

3

High-throughput

0.489

High

717144

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.489

High

457048

CAN1
Calpain-1 catalytic subunit

1

1

Small-scale

0.481

High

61436

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

66136

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

2

High-throughput

0.479

High

183592

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

240845

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

281894

MPPB
Mitochondrial-processing peptidase subunit beta

1

7

High-throughput

0.479

High

287243

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

350798

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

3

High-throughput

0.479

High

411428

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

470868

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

9

High-throughput

0.479

High

486995

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

519054

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

4

High-throughput

0.479

High

532386

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

717040

MDHM
Malate dehydrogenase, mitochondrial

1

8

High-throughput

0.479

High

717041

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

717042

EFTS
Elongation factor Ts, mitochondrial

1

5

High-throughput

0.479

High

717044

IF2M
Translation initiation factor IF-2, mitochondrial

1

8

High-throughput

0.479

High

717048

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

717064

TFAM
Transcription factor A, mitochondrial

1

7

High-throughput

0.479

High

717065

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

717067

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

717069

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

4

High-throughput

0.479

High

717072

QOR
Quinone oxidoreductase

1

3

High-throughput

0.479

High

717073

MPPA
Mitochondrial-processing peptidase subunit alpha

1

7

High-throughput

0.479

High

717083

ICT1
Large ribosomal subunit protein mL62

1

3

High-throughput

0.479

High

717088

PDK1
[Pyruvate dehydrogenase

1

6

High-throughput

0.479

High

717096

SYAM
Alanine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

717099

MRM1
rRNA methyltransferase 1, mitochondrial

1

4

High-throughput

0.479

High

717100

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

717107

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

9

High-throughput

0.479

High

717109

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

4

High-throughput

0.479

High

717123

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

7

High-throughput

0.479

High

717124

FAKD4
FAST kinase domain-containing protein 4

1

9

High-throughput

0.479

High

717125

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

717128

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

717129

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

3

High-throughput

0.479

High

717130

RRFM
Ribosome-recycling factor, mitochondrial

1

3

High-throughput

0.479

High

717131

MTEF3
Transcription termination factor 3, mitochondrial

1

2

High-throughput

0.479

High

717132

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

717133

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

717134

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

717135

EFGM
Elongation factor G, mitochondrial

1

8

High-throughput

0.479

High

717136

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

717139

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

717140

CQ080
Mitochondrial nucleoid-associated protein 1

1

2

High-throughput

0.479

High

717141

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.479

High

717143

TR61B
tRNA

1

3

High-throughput

0.479

High

717145

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

717147

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.479

High

717149

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

5

High-throughput

0.479

High

717150

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

717152

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

717155

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

717157

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

717159

MTG2
Mitochondrial ribosome-associated GTPase 2

1

4

High-throughput

0.479

High

717161

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

717162

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

9

High-throughput

0.479

High

717164

NGRN
Neugrin

1

1

High-throughput

0.479

High

717169

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.479

High

717170

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

717171

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

717172

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.479

High

717173

AKIP
Small ribosomal subunit protein mS38

1

2

High-throughput

0.479

High

717175

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

9

High-throughput

0.479

High

717176

MRES1
Mitochondrial transcription rescue factor 1

1

3

High-throughput

0.479

High

717179

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

717184

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.479

High

717189

DJC15
DnaJ homolog subfamily C member 15

1

3

High-throughput

0.479

High

538885

EPB41
Protein 4.1

1

3

High-throughput

0.470

High

717085

SLMAP
Sarcolemmal membrane-associated protein

1

1

High-throughput

0.470

High

717060

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.464

High

717039

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.462

High

361606

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

717038

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

717090

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

717101

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

717106

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

717126

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

717127

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

717142

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

717156

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

717056

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.457

High

717066

ERCC6
DNA excision repair protein ERCC-6

1

4

High-throughput

0.457

High

529166

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

653146

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.445

High

717086

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

9

Small-scale

0.445

High

717154

S2532
Solute carrier family 25 member 32

1

2

High-throughput

0.445

High

717190

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

5

High-throughput

0.445

High

369317

A1AT
Alpha-1-antitrypsin

1

1

High-throughput

0.439

High

208466

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.437

High

210870

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.437

High

214393

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

5

High-throughput

0.437

High

353015

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.437

High

379897

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.437

High

473810

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.437

High

536574

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

590816

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

659368

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.437

High

717043

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.437

High

717046

PRC2A
Protein PRRC2A

1

1

Small-scale

0.437

High

717047

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

717049

CDK7
Cyclin-dependent kinase 7

1

5

High-throughput

0.437

High

717053

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

4

Small-scale

0.437

High

717055

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

7

High-throughput

0.437

High

717057

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

High-throughput

0.437

High

717058

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.437

High

717061

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.437

High

717063

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.437

High

717070

KLC1
Kinesin light chain 1

1

1

High-throughput

0.437

High

717071

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.437

High

717076

PAK2
Serine/threonine-protein kinase PAK 2

1

1

High-throughput

0.437

High

717077

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.437

High

717078

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

3

High-throughput

0.437

High

717082

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.437

High

717087

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.437

High

717092

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.437

High

717095

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.437

High

717098

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

Small-scale

0.437

High

717102

BRWD3
Bromodomain and WD repeat-containing protein 3

1

8

Small-scale

0.437

High

717103

WDR87
WD repeat-containing protein 87

1

1

Small-scale

0.437

High

717104

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

717105

SND1
Staphylococcal nuclease domain-containing protein 1

1

3

High-throughput

0.437

High

717111

CC146
Coiled-coil domain-containing protein 146

1

5

Small-scale

0.437

High

717116

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.437

High

717119

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

2

Small-scale

0.437

High

717120

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.437

High

717138

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.437

High

717151

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.437

High

717160

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

717165

ANLN
Anillin

1

3

High-throughput

0.437

High

717167

BRWD1
Bromodomain and WD repeat-containing protein 1

1

6

Small-scale

0.437

High

717178

EPHA6
Ephrin type-A receptor 6

1

11

High-throughput

0.437

High

717180

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.437

High

717181

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

3

Small-scale

0.437

High

717182

TNIK
TRAF2 and NCK-interacting protein kinase

1

2

High-throughput

0.437

High

717183

PA2G4
Proliferation-associated protein 2G4

1

1

High-throughput

0.437

High

717185

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.437

High

717187

TRAF6
TNF receptor-associated factor 6

1

12

High-throughput

0.437

High

717188

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.437

High

717089

TLR1
Toll-like receptor 1

1

1

Small-scale

0.417

High

717122

TRI63
E3 ubiquitin-protein ligase TRIM63

1

13

High-throughput

0.417

High

717146

TLR10
Toll-like receptor 10

1

1

Small-scale

0.417

High

717158

SAV1
Protein salvador homolog 1

1

6

Small-scale

0.417

High

717163

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

6

High-throughput

0.417

High

563266

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.407

High

598695

ANFB
Natriuretic peptides B

1

2

High-throughput

0.407

High

689801

CD27
CD27 antigen

1

3

High-throughput

0.407

High

717081

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.407

High

717148

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

717166

ITM2C
Integral membrane protein 2C

1

2

High-throughput

0.407

High

290868

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.282

High

717054

CLD12
Claudin-12

1

0

High-throughput

0.282

High

717108

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.282

High

250473

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.279

Low

717037

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.279

Low

717045

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.279

Low

717059

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.279

Low

717118

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.279

Low

717052

ZN157
Zinc finger protein 157

1

0

High-throughput

0.269

Low

254535

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

377183

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

624222

TFE3
Transcription factor E3

1

0

High-throughput

0.249

Low

717112

RBIS
Ribosomal biogenesis factor

1

0

High-throughput

0.249

Low

717115

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

717137

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

Small-scale

0.249

Low

717153

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

717174

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

717177

TRM7
tRNA

1

0

High-throughput

0.249

Low

717062

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.232

Low

717113

THMS1
Protein THEMIS

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025