Protein: ECHA
Trifunctional enzyme subunit alpha, mitochondrial (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]

Gene: ECHA, Hadha
Organism: Mus musculus
Interactions: 61
UniProt ID: Q8BMS1

Gene Ontology (top 5):
GO:0004300 - enoyl-CoA hydratase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006635 - fatty acid beta-oxidation
GO:0016507 - mitochondrial fatty acid beta-oxidation multienzyme complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1296994

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

3

19

High-throughput

0.827

High

1297002

ECHB
Trifunctional enzyme subunit beta, mitochondrial

3

7

High-throughput

0.827

High

1297013

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

3

5

High-throughput

0.640

High

1297016

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

3

2

High-throughput

0.640

High

397828

ATP8
ATP synthase F(0) complex subunit 8

3

0

High-throughput

0.613

High

469612

MDHM
Malate dehydrogenase, mitochondrial

2

8

High-throughput

0.584

High

878148

ADT1
ADP/ATP translocase 1

2

1

High-throughput

0.584

High

1021432

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

2

1

High-throughput

0.584

High

1297005

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

2

2

High-throughput

0.584

High

968142

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

6

High-throughput

0.521

High

426400

AATM
Aspartate aminotransferase, mitochondrial

1

3

High-throughput

0.479

High

771714

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

9

High-throughput

0.479

High

853087

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

9

High-throughput

0.479

High

866547

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

939850

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

1

High-throughput

0.479

High

940836

ATPB
ATP synthase F(1) complex catalytic subunit beta, mitochondrial

1

8

High-throughput

0.479

High

989410

MPC1
Mitochondrial pyruvate carrier 1

1

1

High-throughput

0.479

High

1042146

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

8

High-throughput

0.479

High

1054091

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

1

High-throughput

0.479

High

1221173

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

8

High-throughput

0.479

High

1282903

Q80X68
Citrate synthase

1

9

High-throughput

0.479

High

1296999

S25A3
Solute carrier family 25 member 3

1

2

High-throughput

0.479

High

1297000

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

1

High-throughput

0.479

High

1297003

ACON
Aconitate hydratase, mitochondrial

1

2

High-throughput

0.479

High

1297004

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

1297006

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

High-throughput

0.479

High

1297008

TOM34
Mitochondrial import receptor subunit TOM34

1

4

High-throughput

0.479

High

1297009

MPC2
Mitochondrial pyruvate carrier 2

1

1

High-throughput

0.479

High

1297011

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

1

High-throughput

0.479

High

1297012

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.479

High

1297015

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

1297001

EED
Polycomb protein EED

1

2

High-throughput

0.470

High

204367

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.458

High

926042

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

1297007

ACO13
Acyl-coenzyme A thioesterase 13

1

0

High-throughput

0.458

High

1297010

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

591063

KPCE
Protein kinase C epsilon type

1

3

Small-scale

0.445

High

1021709

THIOM
Thioredoxin, mitochondrial

1

2

High-throughput

0.445

High

108756

G3X9H5
Huntingtin

1

3

High-throughput

0.437

High

147835

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.437

High

398651

CFAD
Complement factor D

1

7

High-throughput

0.437

High

555195

FABPL
Fatty acid-binding protein, liver

1

1

High-throughput

0.437

High

629355

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.437

High

789749

THB
Thyroid hormone receptor beta

1

2

High-throughput

0.437

High

1210784

CLU
Clustered mitochondria protein homolog

1

1

High-throughput

0.437

High

1221318

PPP5
Serine/threonine-protein phosphatase 5

1

6

High-throughput

0.437

High

1257370

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.437

High

1282142

FACD2
Fanconi anemia group D2 protein homolog

1

2

High-throughput

0.437

High

1296017

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

4

High-throughput

0.437

High

1296995

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

2

High-throughput

0.437

High

1296998

FNDC5
Fibronectin type III domain-containing protein 5

1

5

High-throughput

0.437

High

1297014

RBCC1
RB1-inducible coiled-coil protein 1

1

1

Small-scale

0.437

High

1193824

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.407

High

1296997

FTM
Protein fantom

1

2

High-throughput

0.407

High

927888

ATX1
Ataxin-1

1

0

High-throughput

0.269

Low

313265

NOE1
Noelin

1

0

Small-scale

0.249

Low

727609

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

0

High-throughput

0.249

Low

898050

TNNT2
Troponin T, cardiac muscle

1

0

High-throughput

0.249

Low

1233030

TEDC2
Tubulin epsilon and delta complex protein 2

1

0

High-throughput

0.249

Low

1296996

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025