HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: AGO4 (Q9HCK5)
Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)
Gene: AGO4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 861
+	Hs
		1035043 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AGO1_HUMAN (8-861): 0: 1157: 83.49
+	Hs
		1035042 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AGO2_HUMAN (12-861): 0: 1151: 78.94
+	Hs
		1035002 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AGO3_HUMAN (5-861): 0: 1146: 81.18
+	Mm
		1145401 FKBP5_MOUSE (1-457): 1.26e-140: 412: 86.87		AGO2_MOUSE (5-861): 0: 1153: 78.19
+	Hs
		972609 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		AGO2_HUMAN (12-861): 0: 1151: 78.94
+	Hs
		59978 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		A4FVC0_HUMAN (62-861): 0: 1080: 79.88
+	Dm
		1103850 FKB59_DROME (20-450): 5.8e-123: 366: 40.69		Q32KD4_DROME (5-861): 0: 1110: 70.68
+	Hs
		118802 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		AGO1_HUMAN (8-861): 0: 1157: 83.49
+	Hs
		1034966 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		PIWL1_HUMAN (17-828): 0: 739: 22.24
+	Hs
		1034939 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		PIWL2_HUMAN (6-824): 0: 699: 22.24
+	Hs
		1034913 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		PIWL4_HUMAN (21-824): 0: 672: 21.68
+	Dm
		1186010 FKB59_DROME (20-450): 5.8e-123: 366: 40.69		AGO3_DROME (21-828): 0: 609: 20.36
+	Hs
		259953 FKBP6_HUMAN (2-137): 2.27e-35: 135: 35.97		PIWL4_HUMAN (21-824): 0: 672: 21.68
+	Hs
		684905 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		PIWL2_HUMAN (6-824): 0: 699: 22.24
+	Dm
		1186011 Q9VPN5_DROME (265-393): 3.01e-20: 94.9: 19.38		AGO3_DROME (21-828): 0: 609: 20.36
+	Dm
		1369530 Q9VPN5_DROME (265-393): 3.01e-20: 94.9: 19.38		PIWI_DROME (21-819): 0: 557: 21.36