Interactor 1: IL18R (Q13478)
Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
Gene: IL18R1

Interactor 2: IL18 (Q14116)
Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
Gene: IL18

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 0.55 0.628

The method score is based on:

Property Details
Experiments 9325300, 12096920, 25261253
Identification Methods competition binding, pull down, x-ray crystallography, molecular sieving
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0006954 - inflammatory response
GO:0030101 - natural killer cell activation
GO:0032729 - positive regulation of type II interferon production
GO:0035655 - interleukin-18-mediated signaling pathway
GO:0051092 - positive regulation of NF-kappaB transcription factor activity
and 2 others

more...

Homologous interactions 0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024