Protein: TOF2
Topoisomerase 1-associated factor 2

Gene: TOF2
Organism: Saccharomyces cerevisiae S288C
Interactions: 56
UniProt ID: Q02208

Gene Ontology (top 5):
GO:0000182 - rDNA binding
GO:0000183 - rDNA heterochromatin formation
GO:0005730 - nucleolus
GO:0005739 - mitochondrion
GO:0007000 - nucleolus organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026805

CDC14
Tyrosine-protein phosphatase CDC14

6

1

Small-scale

0.738

High

678891

CSM1
Monopolin complex subunit CSM1

8

0

Small-scale

0.718

High

864315

NET1
Nucleolar protein NET1

4

2

Small-scale

0.693

High

444791

SIR2
NAD-dependent histone deacetylase SIR2

3

1

Small-scale

0.667

High

149226

FOB1
DNA replication fork-blocking protein FOB1

3

1

Small-scale

0.660

High

1035372

LRS4
Monopolin complex subunit LRS4

2

1

Small-scale

0.584

High

586005

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.536

High

623002

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.536

High

415239

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.529

High

823022

ATAD2
ATPase histone chaperone YTA7

2

2

High-throughput

0.521

High

897491

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.512

High

545953

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.489

High

667148

CG23
G2/mitotic-specific cyclin-3

1

2

High-throughput

0.489

High

794290

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.489

High

1035371

VHS1
Serine/threonine-protein kinase VHS1

1

2

High-throughput

0.489

High

1035375

RIO1
Serine/threonine-protein kinase RIO1

1

1

Small-scale

0.481

High

534301

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.479

High

644974

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

2

High-throughput

0.479

High

692610

NSR1
Nuclear localization sequence-binding protein

1

1

High-throughput

0.479

High

740747

SRP40
Suppressor protein SRP40

1

1

High-throughput

0.479

High

763977

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

864037

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

920932

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

1

High-throughput

0.479

High

1028599

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

679985

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

1035373

RTN1
Reticulon-like protein 1

1

0

Small-scale

0.458

High

1035368

TOF2
Topoisomerase 1-associated factor 2

1

2

High-throughput

0.457

High

527466

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

579922

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.445

High

382292

H4
Histone H4

1

1

Small-scale

0.437

High

459149

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.437

High

646506

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.437

High

700040

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.437

High

707943

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

739552

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

1

High-throughput

0.437

High

740000

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

1

High-throughput

0.437

High

826761

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

858244

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

High-throughput

0.437

High

865709

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

381218

H2B1
Histone H2B.1

1

1

High-throughput

0.407

High

524888

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.407

High

676277

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.407

High

736706

ASF1
Histone chaperone ASF1

1

1

High-throughput

0.407

High

738771

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

1

High-throughput

0.407

High

742210

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.407

High

781786

SET3
SET domain-containing protein 3

1

2

High-throughput

0.407

High

819555

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.407

High

917108

HOS2
Probable histone deacetylase HOS2

1

1

High-throughput

0.407

High

1035369

LGE1
Transcriptional regulatory protein LGE1

1

1

High-throughput

0.407

High

1035377

CAF1A
Chromatin assembly factor 1 subunit A

1

1

High-throughput

0.407

High

1030395

CTF4
DNA polymerase alpha-binding protein

1

0

Small-scale

0.309

High

917625

MLC1
Myosin light chain 1

1

0

High-throughput

0.269

Low

1035370

SLD5
DNA replication complex GINS protein SLD5

1

0

Small-scale

0.249

Low

1035374

CDC45
Cell division control protein 45

1

0

Small-scale

0.249

Low

1035376

SMT3
Ubiquitin-like protein SMT3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025