HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 694 Hs			1 839
+	Hs
		1035376 GAB1_HUMAN (1-694): 0: 547: 100.00		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Mm
		546325 GAB1_MOUSE (1-694): 0: 544: 89.93		NTRK2_MOUSE (6-839): 0: 555: 53.29
+	Hs
		384791 GAB1_HUMAN (1-694): 0: 547: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		507983 GAB1_HUMAN (1-694): 0: 547: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		607961 GAB1_HUMAN (1-694): 0: 547: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		385735 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		1081607 PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		434188 GAB1_HUMAN (1-694): 0: 547: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Mm
		724173 GAB1_MOUSE (1-694): 0: 544: 89.93		RET_MOUSE (493-837): 4.82e-107: 356: 33.62
+	Hs
		435634 GAB1_HUMAN (1-694): 0: 547: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		1035415 GAB1_HUMAN (1-694): 0: 547: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Hs
		508062 PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		508203 PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		385750 PKHA6_HUMAN (5-495): 5.54e-58: 214: 13.33		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		608137 PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		609340 PKHS1_HUMAN (5-310): 1.59e-42: 162: 17.13		FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73
+	Hs
		385546 PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		435765 PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		411498 PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435768 PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16