HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007173 - epidermal growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 694 Hs			1 594
+	Hs
		666100 GAB1_HUMAN (1-694): 0: 547: 100.00		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Mm
		957247 GAB1_MOUSE (1-694): 0: 544: 89.93		SHC1_MOUSE (3-593): 1.24e-176: 514: 47.55
+	Hs
		666193 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		275569 GAB1_HUMAN (1-694): 0: 547: 100.00		BCAR3_HUMAN (342-592): 6.06e-51: 190: 21.13
+	Hs
		986372 GAB1_HUMAN (1-694): 0: 547: 100.00		BTK_HUMAN (312-593): 4.07e-49: 182: 14.47
+	Hs
		522965 GAB1_HUMAN (1-694): 0: 547: 100.00		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		433345 GAB1_HUMAN (1-694): 0: 547: 100.00		YES_HUMAN (355-594): 1.37e-48: 179: 17.31
+	Mm
		403466 GAB1_MOUSE (1-694): 0: 544: 89.93		SRC_MOUSE (361-594): 1.83e-49: 181: 17.46
+	Hs
		442825 GAB1_HUMAN (1-694): 0: 547: 100.00		HCK_HUMAN (360-594): 1.32e-47: 176: 15.54
+	Hs
		433750 GAB1_HUMAN (1-694): 0: 547: 100.00		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		426958 GAB1_HUMAN (1-694): 0: 547: 100.00		FES_HUMAN (431-594): 4.92e-36: 146: 22.56
+	Hs
		924547 GAB1_HUMAN (1-694): 0: 547: 100.00		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Mm
		1141170 GAB1_MOUSE (1-694): 0: 544: 89.93		GRB2_MOUSE (445-594): 3.77e-35: 133: 22.08
+	Hs
		523213 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		434086 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		557681 GAB1_HUMAN (1-694): 0: 547: 100.00		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56
+	Hs
		1035400 GAB1_HUMAN (1-694): 0: 547: 100.00		SH23A_HUMAN (492-590): 1.06e-12: 72.9: 30.56
+	Hs
		924959 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Mm
		69824 GAB2_MOUSE (3-691): 8.7e-141: 429: 38.33		B1AT92_MOUSE (445-594): 2.56e-35: 133: 22.08
+	Hs
		557834 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56