HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: SLAP2 (Q9H6Q3)
Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
Gene: SLA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035591 - signaling adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 694 Hs			1 261
+	Hs
		442825 GAB1_HUMAN (1-694): 0: 547: 100.00		HCK_HUMAN (7-259): 4.34e-81: 254: 30.39
+	Hs
		433750 GAB1_HUMAN (1-694): 0: 547: 100.00		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		433345 GAB1_HUMAN (1-694): 0: 547: 100.00		YES_HUMAN (33-259): 1.87e-78: 248: 32.34
+	Hs
		411709 GAB1_HUMAN (1-694): 0: 547: 100.00		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Hs
		522965 GAB1_HUMAN (1-694): 0: 547: 100.00		SRC_HUMAN (13-259): 9.05e-77: 243: 31.37
+	Hs
		846468 GAB1_HUMAN (1-694): 0: 547: 100.00		BLK_HUMAN (2-259): 4.45e-77: 243: 30.88
+	Mm
		403466 GAB1_MOUSE (1-694): 0: 544: 89.93		SRC_MOUSE (13-259): 1.04e-76: 243: 31.37
+	Hs
		986372 GAB1_HUMAN (1-694): 0: 547: 100.00		BTK_HUMAN (10-260): 1.44e-64: 214: 21.46
+	Hs
		996561 GAB1_HUMAN (1-694): 0: 547: 100.00		ITK_HUMAN (8-260): 7.03e-64: 211: 22.56
+	Hs
		788991 GAB1_HUMAN (1-694): 0: 547: 100.00		TEC_HUMAN (7-260): 1.36e-62: 208: 21.81
+	Hs
		1028466 GAB1_HUMAN (1-694): 0: 547: 100.00		SLAP1_HUMAN (13-259): 4.83e-60: 193: 38.49
+	Hs
		1035373 GAB1_HUMAN (1-694): 0: 547: 100.00		PTK6_HUMAN (26-251): 9.18e-58: 192: 22.88
+	Hs
		434086 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		523213 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		SRC_HUMAN (13-259): 9.05e-77: 243: 31.37
+	Hs
		275195 GAB1_HUMAN (1-694): 0: 547: 100.00		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14
+	Hs
		924547 GAB1_HUMAN (1-694): 0: 547: 100.00		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Mm
		292690 GAB1_MOUSE (1-694): 0: 544: 89.93		GRAP2_MOUSE (37-176): 1.25e-13: 71.2: 35.71
+	Mm
		1141170 GAB1_MOUSE (1-694): 0: 544: 89.93		GRB2_MOUSE (37-176): 3.68e-13: 68.6: 32.39
+	Hs
		275242 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14
+	Hs
		924959 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39