HitPredict

Interactor 1: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Interactor 2: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Hs			1 151
+	Hs
		849322 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919722 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895788 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		927749 BIRC2_HUMAN (1-618): 0: 702: 100.00		UBE2B_HUMAN (1-146): 2.42e-63: 192: 33.33
+	Hs
		1206094 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849363 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		849321 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919776 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		919721 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895841 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		895787 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1206017 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00
+	Mm
		620834 MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21		UB2D1_MOUSE (4-150): 2.02e-69: 207: 34.69
+	Hs
		849309 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Mm
		620833 MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21		UB2D3_MOUSE (4-150): 3.12e-67: 202: 33.33
+	Hs
		919708 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895778 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		851803 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		828987 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UBE2A_HUMAN (1-146): 7.59e-64: 193: 31.97
+	Hs
		927746 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UBE2B_HUMAN (1-146): 2.42e-63: 192: 33.33