HitPredict

Interactor 1: TFE2 (P15806)
Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1)
Gene: Tcf3

Interactor 2: FER3L (Q923Z4)
Fer3-like protein (Basic helix-loop-helix protein N-twist) (Nephew of atonal 3) (Neuronal twist)
Gene: Ferd3l

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	12217327
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0048468 - cell development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Mm			1 168
+	Mm
		550176 TFE2_MOUSE (1-651): 0: 901: 100.00		TFE2_MOUSE (2-168): 4.84e-31: 119: 24.28
+	Mm
		550186 TFE2_MOUSE (1-651): 0: 901: 100.00		ATOH1_MOUSE (18-167): 5.22e-27: 105: 29.33
+	Mm
		550197 TFE2_MOUSE (1-651): 0: 901: 100.00		NGN2_MOUSE (22-168): 1.41e-27: 105: 27.39
+	Mm
		550212 TFE2_MOUSE (1-651): 0: 901: 100.00		HTF4_MOUSE (1-168): 4.8e-26: 105: 18.44
+	Mm
		550204 TFE2_MOUSE (1-651): 0: 901: 100.00		ITF2_MOUSE (1-168): 7.5e-26: 104: 15.68
+	Mm
		192773 TFE2_MOUSE (1-651): 0: 901: 100.00		TCF21_MOUSE (49-167): 6.05e-27: 101: 24.37
+	Mm
		550207 TFE2_MOUSE (1-651): 0: 901: 100.00		NDF1_MOUSE (94-166): 2.57e-25: 101: 42.47
+	Mm
		550205 TFE2_MOUSE (1-651): 0: 901: 100.00		TCF15_MOUSE (54-166): 1.83e-26: 100: 33.63
+	Mm
		550211 TFE2_MOUSE (1-651): 0: 901: 100.00		HAND2_MOUSE (102-164): 1.97e-25: 98.6: 38.10
+	Rn
		600265 TFE2_RAT (1-651): 0: 899: 95.08		Q9EPJ1_RAT (58-163): 1.91e-25: 98.2: 36.79
+	Mm
		550182 TFE2_MOUSE (1-651): 0: 901: 100.00		TWST1_MOUSE (95-163): 3.75e-24: 95.1: 44.93
+	Hs
		551462 TFE2_HUMAN (2-651): 0: 854: 80.52		TFE2_HUMAN (2-168): 5.84e-33: 124: 21.39
+	Hs
		526739 TFE2_HUMAN (2-651): 0: 854: 80.52		MYF5_HUMAN (33-162): 6.56e-29: 108: 25.56
+	Hs
		551056 TFE2_HUMAN (2-651): 0: 854: 80.52		ITF2_HUMAN (1-168): 3.17e-25: 102: 16.02
+	Hs
		551521 TFE2_HUMAN (2-651): 0: 854: 80.52		NDF1_HUMAN (94-166): 8.68e-26: 102: 42.47
+	Hs
		210857 TFE2_HUMAN (2-651): 0: 854: 80.52		TCF21_HUMAN (49-167): 2.18e-26: 100: 24.37
+	Hs
		551472 TFE2_HUMAN (2-651): 0: 854: 80.52		MYF6_HUMAN (32-166): 6.99e-26: 100: 25.19
+	Hs
		551490 TFE2_HUMAN (2-651): 0: 854: 80.52		HAND2_HUMAN (102-164): 1.97e-25: 98.6: 38.10
+	Hs
		551505 TFE2_HUMAN (2-651): 0: 854: 80.52		HEN2_HUMAN (40-160): 3.46e-25: 95.6: 30.77
+	Hs
		551504 TFE2_HUMAN (2-651): 0: 854: 80.52		HEN1_HUMAN (100-159): 6.35e-24: 92.4: 46.67