Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1
Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.72 | 1.00 | 0.853 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 27631370, 29519959 |
| Identification Methods | affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, protein kinase assay |
| Interaction Type | physical association, direct interaction, phosphorylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PB1~Pkinase |
| Common GO terms | GO:0001934 - positive regulation of protein phosphorylation GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol and 9 others more... |
| Homologous interactions | 7 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
