Protein: CDK5
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)

Gene: CDK5
Organism: Homo sapiens
Interactions: 213
UniProt ID: Q00535

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001764 - neuron migration
GO:0001963 - synaptic transmission, dopaminergic
GO:0002039 - p53 binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1025461

CD5R1
Cyclin-dependent kinase 5 activator 1

20

7

Small-scale

0.990

High

718803

CCND2
G1/S-specific cyclin-D2

12

20

Small-scale

0.985

High

857311

CDN1B
Cyclin-dependent kinase inhibitor 1B

11

20

Small-scale

0.983

High

573802

CCNB1
G2/mitotic-specific cyclin-B1

9

20

High-throughput

0.976

High

1025491

CABL1
CDK5 and ABL1 enzyme substrate 1

9

8

Small-scale

0.975

High

718883

CCND3
G1/S-specific cyclin-D3

8

20

High-throughput

0.973

High

808023

CDN1A
Cyclin-dependent kinase inhibitor 1

6

20

Small-scale

0.956

High

1025503

CABL2
CDK5 and ABL1 enzyme substrate 2

6

8

Small-scale

0.950

High

1025459

CCNI
Cyclin-I

5

20

High-throughput

0.924

High

664710

CCND1
G1/S-specific cyclin-D1

5

20

High-throughput

0.916

High

1025251

CDK3
Cyclin-dependent kinase 3

4

17

High-throughput

0.909

High

629102

CCNA2
Cyclin-A2

4

20

High-throughput

0.903

High

1025474

CCNI2
Cyclin-I2

4

20

High-throughput

0.892

High

241410

PRKN
E3 ubiquitin-protein ligase parkin

3

9

Small-scale

0.865

High

322099

CDK14
Cyclin-dependent kinase 14

3

18

High-throughput

0.861

High

666975

CCNE1
G1/S-specific cyclin-E1

3

20

High-throughput

0.861

High

1025485

CDK20
Cyclin-dependent kinase 20

3

15

High-throughput

0.861

High

1025464

CDC37
Hsp90 co-chaperone Cdc37

2

6

High-throughput

0.817

High

1025505

DCLK3
Serine/threonine-protein kinase DCLK3

2

12

High-throughput

0.811

High

1025446

CDK16
Cyclin-dependent kinase 16

2

17

Small-scale

0.799

High

1025469

SPDYA
Speedy protein A

2

17

High-throughput

0.783

High

1025504

CNPD1
Protein CNPPD1

2

0

High-throughput

0.770

High

719211

MPIP2
M-phase inducer phosphatase 2

2

18

Small-scale

0.768

High

66883

SPDE4
Speedy protein E4

3

17

High-throughput

0.768

High

529637

TAU
Microtubule-associated protein tau

13

8

Small-scale

0.761

High

1025445

CDK5
Cyclin-dependent kinase 5

2

17

High-throughput

0.754

High

1025480

C2CD5
C2 domain-containing protein 5

8

3

High-throughput

0.754

High

1025475

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

Small-scale

0.747

High

1025470

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

12

Small-scale

0.737

High

1025455

PAK1
Serine/threonine-protein kinase PAK 1

1

11

Small-scale

0.724

High

216001

FIBP
Acidic fibroblast growth factor intracellular-binding protein

9

0

High-throughput

0.723

High

789471

PPARG
Peroxisome proliferator-activated receptor gamma

4

9

Small-scale

0.699

High

1025528

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

11

High-throughput

0.698

High

461363

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

468269

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.691

High

651126

CCNO
Cyclin-O

1

20

High-throughput

0.691

High

667779

CDK2
Cyclin-dependent kinase 2

1

18

High-throughput

0.691

High

1025320

CDK6
Cyclin-dependent kinase 6

1

18

High-throughput

0.691

High

1025451

FAK1
Focal adhesion kinase 1

1

16

High-throughput

0.691

High

1025452

CDK18
Cyclin-dependent kinase 18

1

17

High-throughput

0.691

High

1025454

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

9

High-throughput

0.691

High

1025490

MK15
Mitogen-activated protein kinase 15

1

19

High-throughput

0.691

High

1025525

AURKC
Aurora kinase C

1

8

High-throughput

0.691

High

1025447

H11
Histone H1.1

4

20

Small-scale

0.686

High

1025484

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

Small-scale

0.680

High

881883

TCPG
T-complex protein 1 subunit gamma

3

19

High-throughput

0.675

High

899000

TCPQ
T-complex protein 1 subunit theta

3

20

High-throughput

0.675

High

899350

TCPD
T-complex protein 1 subunit delta

3

15

High-throughput

0.675

High

1025501

TCPH
T-complex protein 1 subunit eta

3

19

High-throughput

0.675

High

1025488

MDGA1
MAM domain-containing glycosylphosphatidylinositol anchor protein 1

1

2

High-throughput

0.665

High

958084

ARP3
Actin-related protein 3

1

6

High-throughput

0.665

High

1025523

FZR1
Fizzy-related protein homolog

3

16

Small-scale

0.664

High

1025453

TMM94
Transmembrane protein 94

5

1

High-throughput

0.659

High

550988

PCNA
Proliferating cell nuclear antigen

3

6

Small-scale

0.656

High

719131

MPIP1
M-phase inducer phosphatase 1

1

18

Small-scale

0.647

High

719312

MPIP3
M-phase inducer phosphatase 3

1

18

Small-scale

0.647

High

1025450

DYN1
Dynamin-1

1

3

Small-scale

0.647

High

610625

TCPA
T-complex protein 1 subunit alpha

2

16

High-throughput

0.628

High

821311

TCPZ
T-complex protein 1 subunit zeta

2

14

High-throughput

0.628

High

875920

TCPE
T-complex protein 1 subunit epsilon

2

19

High-throughput

0.628

High

1006980

TCPB
T-complex protein 1 subunit beta

2

19

High-throughput

0.628

High

876578

NEST
Nestin

2

18

Small-scale

0.624

High

856640

BAG6
Large proline-rich protein BAG6

1

10

High-throughput

0.621

High

1025522

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.618

High

126549

RHOD
Rho-related GTP-binding protein RhoD

1

13

High-throughput

0.618

High

171693

GAK
Cyclin-G-associated kinase

1

7

Small-scale

0.618

High

296981

CCNK
Cyclin-K

1

20

High-throughput

0.618

High

318726

RHBT1
Rho-related BTB domain-containing protein 1

1

11

High-throughput

0.618

High

325481

CCNB2
G2/mitotic-specific cyclin-B2

1

20

High-throughput

0.618

High

363138

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.618

High

373882

RASN
GTPase NRas

1

14

High-throughput

0.618

High

411745

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.618

High

580992

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.618

High

601240

RHOQ
Rho-related GTP-binding protein RhoQ

1

11

High-throughput

0.618

High

666823

CCNC
Cyclin-C

1

20

High-throughput

0.618

High

710176

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.618

High

753914

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

20

High-throughput

0.618

High

830571

CCNF
Cyclin-F

1

20

High-throughput

0.618

High

845603

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

891453

GSK3B
Glycogen synthase kinase-3 beta

1

19

Small-scale

0.618

High

897237

CDK7
Cyclin-dependent kinase 7

1

17

High-throughput

0.618

High

910011

RND2
Rho-related GTP-binding protein RhoN

1

15

High-throughput

0.618

High

953394

RAC3
Ras-related C3 botulinum toxin substrate 3

1

9

High-throughput

0.618

High

955064

CDC42
Cell division control protein 42 homolog

1

10

High-throughput

0.618

High

956647

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

20

High-throughput

0.618

High

961956

RHOA
Transforming protein RhoA

1

10

High-throughput

0.618

High

962708

RND3
Rho-related GTP-binding protein RhoE

1

15

High-throughput

0.618

High

977938

RHOB
Rho-related GTP-binding protein RhoB

1

11

High-throughput

0.618

High

988282

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.618

High

1015369

RHOG
Rho-related GTP-binding protein RhoG

1

8

High-throughput

0.618

High

1025448

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

9

Small-scale

0.618

High

1025458

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

9

Small-scale

0.618

High

1025462

RHOH
Rho-related GTP-binding protein RhoH

1

12

High-throughput

0.618

High

1025468

LARP7
La-related protein 7

1

20

High-throughput

0.618

High

1025472

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.618

High

1025476

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

1025478

RHOU
Rho-related GTP-binding protein RhoU

1

11

High-throughput

0.618

High

1025493

RND1
Rho-related GTP-binding protein Rho6

1

14

High-throughput

0.618

High

1025497

CHFR
E3 ubiquitin-protein ligase CHFR

1

6

Small-scale

0.618

High

1025508

RHOJ
Rho-related GTP-binding protein RhoJ

1

11

High-throughput

0.618

High

1025509

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.618

High

1025513

RHOF
Rho-related GTP-binding protein RhoF

1

12

High-throughput

0.618

High

1025518

AFF4
AF4/FMR2 family member 4

1

4

High-throughput

0.618

High

421933

A4
Amyloid-beta precursor protein

2

7

High-throughput

0.611

High

895196

5HT6R
5-hydroxytryptamine receptor 6

1

0

Small-scale

0.586

High

1025481

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.586

High

413630

P53
Cellular tumor antigen p53

1

6

Small-scale

0.561

High

1025467

ANR55
Ankyrin repeat domain-containing protein 55

1

1

High-throughput

0.553

High

1025489

SPDE1
Speedy protein E1

1

17

Small-scale

0.553

High

861568

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

High-throughput

0.536

High

488455

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

Small-scale

0.536

High

731204

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.536

High

1025482

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1025495

ARRD3
Arrestin domain-containing protein 3

1

3

High-throughput

0.536

High

1025496

RSPRY
RING finger and SPRY domain-containing protein 1

1

5

High-throughput

0.536

High

1025483

TRI59
Tripartite motif-containing protein 59

1

12

Small-scale

0.528

High

599750

YBOX3
Y-box-binding protein 3

1

1

Small-scale

0.527

High

880285

RL34
Large ribosomal subunit protein eL34

1

2

Small-scale

0.527

High

889967

PSN1
Presenilin-1

1

0

High-throughput

0.518

High

1025507

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

408810

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

10

High-throughput

0.515

High

986343

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.515

High

1025471

Q6FHY5
MEOX2 protein

1

9

High-throughput

0.515

High

1025520

HOOK1
Protein Hook homolog 1

1

16

High-throughput

0.515

High

1025533

NUMBL
Numb-like protein

1

4

High-throughput

0.515

High

66001

U119B
Protein unc-119 homolog B

1

0

High-throughput

0.513

High

359637

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.513

High

772603

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.513

High

1025492

POF1B
Protein POF1B

1

0

High-throughput

0.513

High

560849

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

1

High-throughput

0.508

High

216669

HTRA2
Serine protease HTRA2, mitochondrial

1

2

Small-scale

0.501

High

245800

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

6

Small-scale

0.501

High

286360

DAB1
Disabled homolog 1

1

4

Small-scale

0.501

High

388061

MBP
Myelin basic protein

1

2

Small-scale

0.501

High

442671

RB
Retinoblastoma-associated protein

1

10

Small-scale

0.501

High

455748

H10
Histone H1.0

1

8

Small-scale

0.501

High

595396

H15
Histone H1.5

1

20

Small-scale

0.501

High

883035

AMPH
Amphiphysin

1

2

Small-scale

0.501

High

967666

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

13

Small-scale

0.501

High

1025465

STX1A
Syntaxin-1A

1

2

Small-scale

0.501

High

1025466

KI26B
Kinesin-like protein KIF26B

1

10

Small-scale

0.501

High

1025499

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

6

High-throughput

0.501

High

1025500

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

Small-scale

0.501

High

1025506

NDEL1
Nuclear distribution protein nudE-like 1

1

9

Small-scale

0.501

High

1025529

FYV1
1-phosphatidylinositol 3-phosphate 5-kinase

1

18

Small-scale

0.501

High

1025532

TLN1
Talin-1

1

13

Small-scale

0.501

High

460498

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

4

Small-scale

0.500

High

628748

TBP
TATA-box-binding protein

1

0

High-throughput

0.493

High

660255

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.493

High

893821

MEOX2
Homeobox protein MOX-2

1

9

High-throughput

0.481

High

130069

PGRC1
Membrane-associated progesterone receptor component 1

1

4

Small-scale

0.479

High

256834

H2B1K
Histone H2B type 1-K

1

7

High-throughput

0.479

High

258106

IF2P
Eukaryotic translation initiation factor 5B

1

5

High-throughput

0.479

High

259801

BRD4
Bromodomain-containing protein 4

1

11

High-throughput

0.479

High

279342

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

293569

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

324795

HEXI1
Protein HEXIM1

1

7

High-throughput

0.479

High

521646

H14
Histone H1.4

1

20

High-throughput

0.479

High

588478

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

596045

H12
Histone H1.2

1

20

High-throughput

0.479

High

684975

DNMT1
DNA

1

8

Small-scale

0.479

High

687218

HMGB2
High mobility group protein B2

1

9

High-throughput

0.479

High

695226

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

767169

MERL
Merlin

1

3

High-throughput

0.479

High

767969

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

835435

GRM5
Metabotropic glutamate receptor 5

1

1

Small-scale

0.479

High

858764

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

6

Small-scale

0.479

High

884317

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

2

High-throughput

0.479

High

925901

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

3

High-throughput

0.479

High

940917

HDAC4
Histone deacetylase 4

1

6

Small-scale

0.479

High

963403

STXB1
Syntaxin-binding protein 1

1

2

Small-scale

0.479

High

970343

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

980699

H2B1C
Histone H2B type 1-C/E/F/G/I

1

7

High-throughput

0.479

High

1013127

SARNP
SAP domain-containing ribonucleoprotein

1

2

High-throughput

0.479

High

1025449

ENL
Protein ENL

1

6

High-throughput

0.479

High

1025456

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.479

High

1025457

SKP2
S-phase kinase-associated protein 2

1

5

High-throughput

0.479

High

1025463

SEPT7
Septin-7

1

5

High-throughput

0.479

High

1025479

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1025486

RPTOR
Regulatory-associated protein of mTOR

1

7

High-throughput

0.479

High

1025487

SERB1
SERPINE1 mRNA-binding protein 1

1

9

High-throughput

0.479

High

1025498

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1025502

LZTS2
Leucine zipper putative tumor suppressor 2

1

17

High-throughput

0.479

High

1025510

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.479

High

1025511

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

1025512

GORS2
Golgi reassembly-stacking protein 2

1

4

High-throughput

0.479

High

1025515

SEP11
Septin-11

1

5

High-throughput

0.479

High

1025516

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

4

High-throughput

0.479

High

1025517

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1025519

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

1

High-throughput

0.479

High

1025521

FBW1B
F-box/WD repeat-containing protein 11

1

9

High-throughput

0.479

High

1025524

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

Small-scale

0.479

High

1025527

DRG1
Developmentally-regulated GTP-binding protein 1

1

3

High-throughput

0.479

High

1025530

RRP44
Exosome complex exonuclease RRP44

1

3

High-throughput

0.479

High

1025531

SHLB1
Endophilin-B1

1

2

High-throughput

0.479

High

142940

NFIB
Nuclear factor 1 B-type

1

0

High-throughput

0.458

High

377538

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

963993

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.458

High

1025460

ODFP1
Outer dense fiber protein 1

1

0

Small-scale

0.458

High

1025494

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.458

High

1025514

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

409352

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.445

High

1025526

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

431551

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.438

High

1025477

CE128
Centrosomal protein of 128 kDa

1

17

High-throughput

0.437

High

591277

CD44
CD44 antigen

1

0

High-throughput

0.426

High

616740

SDC1
Syndecan-1

1

0

High-throughput

0.426

High

1010020

DLK1
Protein delta homolog 1

1

0

High-throughput

0.426

High

296699

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

389732

FETUA
Alpha-2-HS-glycoprotein

1

0

High-throughput

0.279

Low

528438

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.249

Low

1025473

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025