HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	19843958, 19903815
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PB1~PB1, PB1~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 626
+	Mm
		1142139 SQSTM_MOUSE (1-440): 0: 731: 90.72		M3K3_MOUSE (1-626): 0: 585: 96.65
+	Hs
		1037017 SQSTM_HUMAN (1-440): 0: 760: 100.00		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		984491 SQSTM_HUMAN (1-440): 0: 760: 100.00		KPCD_HUMAN (22-625): 8.67e-139: 421: 17.86
+	Rn
		139610 SQSTM_RAT (1-440): 0: 746: 90.95		KPCD_RAT (22-625): 4.95e-139: 422: 17.43
+	Mm
		661009 SQSTM_MOUSE (1-440): 0: 731: 90.72		KPCD_MOUSE (22-625): 1.02e-139: 424: 17.59
+	Rn
		139624 SQSTM_RAT (1-440): 0: 746: 90.95		KPCL_RAT (207-625): 7.8e-127: 390: 19.17
+	Hs
		1056108 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		1206100 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		M3K4_HUMAN (341-624): 3.69e-51: 193: 39.10