Protein: SP3
Transcription factor Sp3 (SPR-2)

Gene: SP3
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q02447

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

464917

SP1
Transcription factor Sp1

7

18

Small-scale

0.962

High

1036874

HDAC1
Histone deacetylase 1

6

20

Small-scale

0.721

High

395947

ESR1
Estrogen receptor

4

20

Small-scale

0.683

High

1036873

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.676

High

624035

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

7

Small-scale

0.665

High

728182

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.647

High

1036894

HDAC2
Histone deacetylase 2

3

20

Small-scale

0.640

High

413659

P53
Cellular tumor antigen p53

2

10

Small-scale

0.624

High

180146

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

20

Small-scale

0.618

High

675466

TYY1
Transcriptional repressor protein YY1

1

19

Small-scale

0.618

High

574225

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

1

High-throughput

0.606

High

1036885

LIN54
Protein lin-54 homolog

2

3

High-throughput

0.606

High

1036888

POGZ
Pogo transposable element with ZNF domain

2

17

High-throughput

0.606

High

1036897

PF21A
PHD finger protein 21A

2

20

High-throughput

0.606

High

1036898

SGCZ
Zeta-sarcoglycan

3

1

High-throughput

0.599

High

843496

HD
Huntingtin

2

6

High-throughput

0.596

High

606653

CEBPB
CCAAT/enhancer-binding protein beta

2

12

Small-scale

0.584

High

1036868

TF65
Transcription factor p65

2

15

Small-scale

0.584

High

1036869

GABPA
GA-binding protein alpha chain

1

20

Small-scale

0.578

High

1029059

E2F1
Transcription factor E2F1

1

9

Small-scale

0.561

High

1036877

HLTF
Helicase-like transcription factor

1

16

Small-scale

0.561

High

1036884

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

2

6

High-throughput

0.553

High

1036899

CIB3
Calcium and integrin-binding family member 3

2

4

High-throughput

0.553

High

665570

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

1

High-throughput

0.536

High

1036876

FHL2
Four and a half LIM domains protein 2

1

9

High-throughput

0.536

High

297577

PIAS1
E3 SUMO-protein ligase PIAS1

1

4

Small-scale

0.527

High

1036891

FNDC8
Fibronectin type III domain-containing protein 8

1

0

High-throughput

0.513

High

186734

P73
Tumor protein p73

1

10

Small-scale

0.501

High

585451

VEGFA
Vascular endothelial growth factor A, long form

1

1

Small-scale

0.501

High

1036901

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.501

High

1036879

PGFRL
Platelet-derived growth factor receptor-like protein

1

1

High-throughput

0.489

High

721710

GCH1
GTP cyclohydrolase 1

1

0

Small-scale

0.486

High

891935

WHR1
Winged helix repair factor 1

1

0

Small-scale

0.486

High

993505

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.481

High

1036900

NKX31
Homeobox protein Nkx-3.1

1

16

Small-scale

0.481

High

209987

CRX
Cone-rod homeobox protein

1

8

Small-scale

0.479

High

280412

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

9

Small-scale

0.479

High

655162

SFPQ
Splicing factor, proline- and glutamine-rich

1

4

Small-scale

0.479

High

684978

DNMT1
DNA

1

11

Small-scale

0.479

High

786550

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

6

Small-scale

0.479

High

788900

TGFR2
TGF-beta receptor type-2

1

2

Small-scale

0.479

High

904617

MECP2
Methyl-CpG-binding protein 2

1

9

Small-scale

0.479

High

925902

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

Small-scale

0.479

High

1031981

TFAP4
Transcription factor AP-4

1

2

Small-scale

0.479

High

1036870

ZO1
Tight junction protein 1

1

5

Small-scale

0.479

High

1036872

RBBP4
Histone-binding protein RBBP4

1

7

Small-scale

0.479

High

1036875

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1036880

PTPA
Serine/threonine-protein phosphatase 2A activator

1

1

Small-scale

0.479

High

1036881

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

2

High-throughput

0.479

High

1036886

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.479

High

1036887

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

1036893

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1036895

CBP
CREB-binding protein

1

20

Small-scale

0.479

High

1036896

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.479

High

1036905

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1036906

XPO7
Exportin-7

1

8

High-throughput

0.479

High

954099

RS20
Small ribosomal subunit protein uS10

1

0

Small-scale

0.460

High

961264

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

467249

MDR1
ATP-dependent translocase ABCB1

1

1

Small-scale

0.457

High

1036902

LN28A
Protein lin-28 homolog A

1

10

High-throughput

0.445

High

1036904

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

539468

ITAM
Integrin alpha-M

1

3

Small-scale

0.437

High

634733

ITAX
Integrin alpha-X

1

3

Small-scale

0.437

High

834956

S19A1
Reduced folate transporter

1

1

Small-scale

0.437

High

956849

CXCR4
C-X-C chemokine receptor type 4

1

2

Small-scale

0.437

High

1036903

IL21R
Interleukin-21 receptor

1

1

Small-scale

0.437

High

880797

NRAM1
Natural resistance-associated macrophage protein 1

1

0

High-throughput

0.426

High

1036871

Q08AT0
SGCZ protein

1

1

High-throughput

0.407

High

377126

TSHB
Thyrotropin subunit beta

2

0

High-throughput

0.328

High

946231

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

2

0

High-throughput

0.318

High

1036892

ITLN1
Intelectin-1

2

0

High-throughput

0.318

High

946302

NXPH1
Neurexophilin-1

1

0

High-throughput

0.279

Low

1036878

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.279

Low

1036883

DB135
Beta-defensin 135

1

0

High-throughput

0.279

Low

1036890

PRS33
Serine protease 33

1

0

High-throughput

0.279

Low

138558

CLD5
Claudin-5

1

0

Small-scale

0.249

Low

251148

B4GT4
Beta-1,4-galactosyltransferase 4

1

0

High-throughput

0.249

Low

1036882

OCLN
Occludin

1

0

Small-scale

0.249

Low

1036889

TMM25
Transmembrane protein 25

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025