HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: TRI55 (Q9BYV6)
Tripartite motif-containing protein 55 (EC 2.3.2.27) (Muscle-specific RING finger protein 2) (MuRF-2) (MuRF2) (RING finger protein 29)
Gene: TRIM55

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	18157088, 15802564
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0030674 - protein-macromolecule adaptor activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 548
+	Mm
		102616 SQSTM_MOUSE (1-440): 0: 731: 90.72		TRI55_MOUSE (1-548): 7.17e-125: 378: 84.00
+	Hs
		1036785 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI63_HUMAN (8-329): 1.6e-80: 257: 61.30
+	Hs
		584950 SQSTM_HUMAN (1-440): 0: 760: 100.00		RO52_HUMAN (12-405): 3.8e-74: 245: 15.87
+	Hs
		1036876 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRIM5_HUMAN (13-396): 3.08e-68: 230: 14.32
+	Hs
		1019298 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI26_HUMAN (12-339): 5.62e-65: 222: 16.23
+	Hs
		536812 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI27_HUMAN (12-434): 9.25e-65: 221: 14.51
+	Hs
		1036807 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI11_HUMAN (12-402): 5.69e-62: 212: 16.88
+	Hs
		242847 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI13_HUMAN (17-333): 3.8e-62: 211: 22.64
+	Mm
		548985 SQSTM_MOUSE (1-440): 0: 731: 90.72		TR30A_MOUSE (13-395): 6.82e-64: 218: 17.78
+	Hs
		1036682 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI67_HUMAN (122-326): 8.33e-14: 76.3: 24.39
+	Hs
		584963 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		RO52_HUMAN (12-405): 3.8e-74: 245: 15.87
+	Hs
		1170674 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		TRI67_HUMAN (122-326): 8.33e-14: 76.3: 24.39
+	Mm
		1118130 HERC2_MOUSE (120-197): 2.07e-12: 71.7: 32.50		TRI67_MOUSE (122-326): 1.29e-13: 75.9: 23.90
+	Hs
		319890 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		TRI67_HUMAN (122-326): 8.33e-14: 76.3: 24.39