Protein: KLF6
Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9)

Gene: KLF6
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q99612

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001650 - fibrillar center

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

465028

SP1
Transcription factor Sp1

3

17

Small-scale

0.857

High

1085816

TF3C1
General transcription factor 3C polypeptide 1

1

2

High-throughput

0.698

High

216987

KLF4
Krueppel-like factor 4

1

19

Small-scale

0.618

High

1398055

ZN512
Zinc finger protein 512

1

20

High-throughput

0.618

High

1405731

ZN644
Zinc finger protein 644

1

20

High-throughput

0.618

High

1159328

TAF9
Transcription initiation factor TFIID subunit 9

2

6

Small-scale

0.595

High

1405730

EPC1
Enhancer of polycomb homolog 1

2

10

High-throughput

0.584

High

1395274

LCOR
Ligand-dependent corepressor

1

0

Small-scale

0.549

High

1396289

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

20

High-throughput

0.541

High

1045686

TF65
Transcription factor p65

1

18

Small-scale

0.536

High

1122764

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.518

High

1405739

PNO1
RNA-binding protein PNO1

1

0

High-throughput

0.518

High

386142

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

16

High-throughput

0.515

High

834358

GARS
Glycine--tRNA ligase

1

1

High-throughput

0.515

High

1279714

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

7

High-throughput

0.515

High

141065

NOP56
Nucleolar protein 56

1

7

Small-scale

0.501

High

422963

A4
Amyloid-beta precursor protein

1

20

High-throughput

0.501

High

644009

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.501

High

552679

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.500

High

617731

XRCC1
DNA repair protein XRCC1

1

1

High-throughput

0.500

High

977059

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

5

High-throughput

0.500

High

995467

TPM4
Tropomyosin alpha-4 chain

1

10

High-throughput

0.500

High

1405752

STRAP
Serine-threonine kinase receptor-associated protein

1

19

High-throughput

0.500

High

1405744

NUFP1
FMR1-interacting protein NUFIP1

1

0

Small-scale

0.480

High

175174

SC16A
Protein transport protein Sec16A

1

14

High-throughput

0.479

High

180911

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

184742

ATX7
Ataxin-7

1

9

High-throughput

0.479

High

188348

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.479

High

284867

TADA3
Transcriptional adapter 3

1

5

High-throughput

0.479

High

284978

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

16

High-throughput

0.479

High

338176

NSA2
Ribosome biogenesis protein NSA2 homolog

1

1

High-throughput

0.479

High

340391

YETS4
YEATS domain-containing protein 4

1

2

High-throughput

0.479

High

346233

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.479

High

556301

CADH1
Cadherin-1

1

2

Small-scale

0.479

High

841436

RBM34
RNA-binding protein 34

1

13

High-throughput

0.479

High

977810

ACTA
Actin, aortic smooth muscle

1

6

High-throughput

0.479

High

1029144

E2F1
Transcription factor E2F1

1

12

Small-scale

0.479

High

1029919

RUNX1
Runt-related transcription factor 1

1

1

Small-scale

0.479

High

1053307

MBTD1
MBT domain-containing protein 1

1

15

High-throughput

0.479

High

1112329

PWP1
Periodic tryptophan protein 1 homolog

1

20

High-throughput

0.479

High

1149277

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

20

Small-scale

0.479

High

1155319

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

5

High-throughput

0.479

High

1157603

TAF12
Transcription initiation factor TFIID subunit 12

1

3

High-throughput

0.479

High

1198112

EPC2
Enhancer of polycomb homolog 2

1

10

High-throughput

0.479

High

1228273

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

1278967

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

20

High-throughput

0.479

High

1287321

TAD2B
Transcriptional adapter 2-beta

1

7

High-throughput

0.479

High

1287979

PB1
Protein polybromo-1

1

20

High-throughput

0.479

High

1310117

MGAP
MAX gene-associated protein

1

15

High-throughput

0.479

High

1314216

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

10

High-throughput

0.479

High

1332216

KRI1
Protein KRI1 homolog

1

3

High-throughput

0.479

High

1337580

SP20H
Transcription factor SPT20 homolog

1

1

High-throughput

0.479

High

1369200

KAT2B
Histone acetyltransferase KAT2B

1

20

High-throughput

0.479

High

1371256

KAT5
Histone acetyltransferase KAT5

1

8

High-throughput

0.479

High

1389679

SGF29
SAGA-associated factor 29

1

1

High-throughput

0.479

High

1392218

DDX27
Probable ATP-dependent RNA helicase DDX27

1

12

High-throughput

0.479

High

1396734

EP400
E1A-binding protein p400

1

20

High-throughput

0.479

High

1401043

PHF12
PHD finger protein 12

1

20

High-throughput

0.479

High

1405723

EBP2
Probable rRNA-processing protein EBP2

1

3

High-throughput

0.479

High

1405725

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

10

High-throughput

0.479

High

1405726

GTPB4
GTP-binding protein 4

1

7

High-throughput

0.479

High

1405728

DDX24
ATP-dependent RNA helicase DDX24

1

14

High-throughput

0.479

High

1405729

BRD8
Bromodomain-containing protein 8

1

20

High-throughput

0.479

High

1405732

EAF6
Chromatin modification-related protein MEAF6

1

1

High-throughput

0.479

High

1405733

TAF9B
Transcription initiation factor TFIID subunit 9B

1

6

High-throughput

0.479

High

1405735

DMAP1
DNA methyltransferase 1-associated protein 1

1

2

High-throughput

0.479

High

1405736

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

1405737

SSF1
Suppressor of SWI4 1 homolog

1

3

High-throughput

0.479

High

1405740

RBM28
RNA-binding protein 28

1

9

High-throughput

0.479

High

1405741

ING3
Inhibitor of growth protein 3

1

15

High-throughput

0.479

High

1405742

DDX56
Probable ATP-dependent RNA helicase DDX56

1

18

High-throughput

0.479

High

1405743

NOP53
Ribosome biogenesis protein NOP53

1

7

High-throughput

0.479

High

1405745

HERC5
E3 ISG15--protein ligase HERC5

1

12

Small-scale

0.479

High

1405746

MRT4
mRNA turnover protein 4 homolog

1

5

High-throughput

0.479

High

1405747

INO80
Chromatin-remodeling ATPase INO80

1

20

High-throughput

0.479

High

1405749

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

3

High-throughput

0.479

High

1405751

NOP16
Nucleolar protein 16

1

6

High-throughput

0.479

High

1405753

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

4

High-throughput

0.479

High

283620

SUPT3
Transcription initiation protein SPT3 homolog

1

0

High-throughput

0.458

High

319169

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.458

High

766220

NOS2
Nitric oxide synthase, inducible

1

0

Small-scale

0.458

High

1135638

AT7L3
Ataxin-7-like protein 3

1

0

High-throughput

0.458

High

1384785

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.458

High

1405738

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.458

High

1160733

DREB
Drebrin

1

8

High-throughput

0.457

High

1311385

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

3

High-throughput

0.457

High

1213434

AT7L2
Ataxin-7-like protein 2

1

4

High-throughput

0.437

High

1405724

CHOLN
Protein cholesin

1

5

High-throughput

0.437

High

1405748

AT7L1
Ataxin-7-like protein 1

1

9

High-throughput

0.437

High

1405750

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.437

High

1405734

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

1

High-throughput

0.417

High

1405727

TNG6
Transport and Golgi organization protein 6 homolog

2

0

High-throughput

0.305

High

337188

APOM
Apolipoprotein M

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025