HitPredict

Interactor 1: PRP4K (Q13523)
Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)
Gene: PRP4K

Interactor 2: U5S1 (Q15029)
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)
Gene: EFTUD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1007 Hs			1 972
+	Hs
		414924 CDK1_HUMAN (684-1005): 4.59e-124: 381: 25.00		U5S1_HUMAN (1-972): 0: 1062: 100.00
+	Hs
		625443 CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45		U5S1_HUMAN (1-972): 0: 1062: 100.00
+	Hs
		531033 CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45		EF2_HUMAN (111-957): 0: 915: 38.16
+	Sc
		565497 PHO85_YEAST (686-1005): 4.97e-117: 363: 27.74		EF2_YEAST (111-957): 0: 879: 36.04
+	Sc
		339503 CDK1_YEAST (686-1005): 2.59e-111: 347: 28.27		EF2_YEAST (111-957): 0: 879: 36.04
+	Hs
		531146 DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65		EF2_HUMAN (111-957): 0: 915: 38.16
+	Zm
		5851 A0A1D6MUS9_MAIZE (7-506): 1.43e-17: 90.3: 11.31		A0A1D6E4M0_MAIZE (120-924): 0: 579: 20.35