Protein: IRF1
Interferon regulatory factor 1 (IRF-1)

Gene: IRF1
Organism: Homo sapiens
Interactions: 156
UniProt ID: P10914

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533921

IRF8
Interferon regulatory factor 8

5

16

Small-scale

0.920

High

533865

IRF2
Interferon regulatory factor 2

4

16

Small-scale

0.878

High

533916

IRF9
Interferon regulatory factor 9

3

15

Small-scale

0.849

High

533962

IRF7
Interferon regulatory factor 7

3

15

Small-scale

0.839

High

533894

STAT1
Signal transducer and activator of transcription 1-alpha/beta

24

20

Small-scale

0.766

High

533888

C2TA
MHC class II transactivator

11

7

Small-scale

0.751

High

533979

CHIP
E3 ubiquitin-protein ligase CHIP

7

3

Small-scale

0.749

High

533927

EP300
Histone acetyltransferase p300

6

17

Small-scale

0.726

High

533925

TF65
Transcription factor p65

5

20

Small-scale

0.702

High

533917

MDM2
E3 ubiquitin-protein ligase Mdm2

4

2

Small-scale

0.694

High

378355

IFNB
Interferon beta

4

20

Small-scale

0.676

High

390379

CXL10
C-X-C motif chemokine 10

4

10

Small-scale

0.676

High

533875

NFKB1
Nuclear factor NF-kappa-B p105 subunit

4

20

Small-scale

0.676

High

533892

STAT3
Signal transducer and activator of transcription 3

4

20

Small-scale

0.676

High

533871

SPI1
Transcription factor PU.1

2

10

Small-scale

0.646

High

533934

IRF3
Interferon regulatory factor 3

1

16

Small-scale

0.646

High

533923

TAP1
Antigen peptide transporter 1

5

3

Small-scale

0.641

High

533929

TIF1B
Transcription intermediary factor 1-beta

2

13

Small-scale

0.639

High

227335

SPOP
Speckle-type POZ protein

2

2

Small-scale

0.625

High

533930

BIRC3
Baculoviral IAP repeat-containing protein 3

2

3

Small-scale

0.624

High

533931

IRF5
Interferon regulatory factor 5

1

15

Small-scale

0.618

High

533885

IL12A
Interleukin-12 subunit alpha

4

7

Small-scale

0.617

High

191199

TLR3
Toll-like receptor 3

2

13

Small-scale

0.601

High

193191

SOCS1
Suppressor of cytokine signaling 1

2

8

Small-scale

0.601

High

378227

IFNA1
Interferon alpha-1/13

2

20

Small-scale

0.601

High

533900

TNF10
Tumor necrosis factor ligand superfamily member 10

2

7

Small-scale

0.601

High

533936

CASP8
Caspase-8

2

3

Small-scale

0.601

High

533943

XAF1
XIAP-associated factor 1

2

0

Small-scale

0.598

High

533958

CBP
CREB-binding protein

2

17

Small-scale

0.595

High

533960

KAT2B
Histone acetyltransferase KAT2B

2

8

Small-scale

0.595

High

416944

CY24B
NADPH oxidase 2

3

3

Small-scale

0.585

High

533872

VCAM1
Vascular cell adhesion protein 1

3

1

Small-scale

0.585

High

425275

ISG15
Ubiquitin-like protein ISG15

2

10

Small-scale

0.584

High

488041

IFI6
Interferon alpha-inducible protein 6

2

1

Small-scale

0.584

High

518753

IL8
Interleukin-8

2

10

Small-scale

0.584

High

533891

PSB10
Proteasome subunit beta type-10

2

9

Small-scale

0.584

High

533935

STAT4
Signal transducer and activator of transcription 4

2

20

Small-scale

0.584

High

533947

IFNL1
Interferon lambda-1

2

7

Small-scale

0.584

High

533982

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.584

High

533940

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.582

High

533928

TRAF3
TNF receptor-associated factor 3

1

20

High-throughput

0.578

High

533959

KAT2A
Histone acetyltransferase KAT2A

1

14

Small-scale

0.561

High

533981

DCAF1
DDB1- and CUL4-associated factor 1

1

1

Small-scale

0.561

High

446586

NPM
Nucleophosmin

1

0

Small-scale

0.554

High

533899

GSK3B
Glycogen synthase kinase-3 beta

1

0

Small-scale

0.554

High

533911

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.554

High

533932

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.554

High

533910

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.536

High

345039

RIGI
Antiviral innate immune response receptor RIG-I

1

7

Small-scale

0.534

High

533867

INGR1
Interferon gamma receptor 1

1

3

Small-scale

0.534

High

533897

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

High-throughput

0.518

High

424311

IL4
Interleukin-4

1

3

Small-scale

0.515

High

533864

CCL5
C-C motif chemokine 5

1

10

Small-scale

0.515

High

533869

CEBPB
CCAAT/enhancer-binding protein beta

1

3

Small-scale

0.515

High

533873

NUCL
Nucleolin

1

1

High-throughput

0.515

High

533903

HCFC1
Host cell factor 1

1

4

High-throughput

0.515

High

533909

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

5

Small-scale

0.515

High

533950

TRM2A
tRNA

1

1

High-throughput

0.515

High

533969

MYD88
Myeloid differentiation primary response protein MyD88

1

20

Small-scale

0.515

High

378408

IFNG
Interferon gamma

1

0

Small-scale

0.512

High

533898

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.481

High

533868

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.480

High

533918

SET
Protein SET

1

0

Small-scale

0.480

High

137373

BT3A3
Butyrophilin subfamily 3 member A3

1

11

Small-scale

0.479

High

154613

ARI1A
AT-rich interactive domain-containing protein 1A

1

9

High-throughput

0.479

High

225400

CIKS
E3 ubiquitin ligase TRAF3IP2

1

1

Small-scale

0.479

High

282663

E2F6
Transcription factor E2F6

1

1

High-throughput

0.479

High

299040

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

369151

OAS1
2'-5'-oligoadenylate synthase 1

1

2

Small-scale

0.479

High

377931

TNFA
Tumor necrosis factor

1

7

Small-scale

0.479

High

378248

IFNA2
Interferon alpha-2

1

20

Small-scale

0.479

High

378326

IFN14
Interferon alpha-14

1

20

Small-scale

0.479

High

378602

IL2RA
Interleukin-2 receptor subunit alpha

1

1

Small-scale

0.479

High

403777

GCR
Glucocorticoid receptor

1

5

Small-scale

0.479

High

461073

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

517510

GLI3
Transcriptional activator GLI3

1

1

Small-scale

0.479

High

519321

MYB
Transcriptional activator Myb

1

2

Small-scale

0.479

High

519688

ANDR
Androgen receptor

1

4

Small-scale

0.479

High

533870

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

1

Small-scale

0.479

High

533874

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

1

Small-scale

0.479

High

533876

NCF2
Neutrophil cytosol factor 2

1

3

Small-scale

0.479

High

533879

CBL
E3 ubiquitin-protein ligase CBL

1

13

Small-scale

0.479

High

533881

RBTN2
Rhombotin-2

1

1

Small-scale

0.479

High

533882

PSB8
Proteasome subunit beta type-8

1

9

Small-scale

0.479

High

533886

IL12B
Interleukin-12 subunit beta

1

8

Small-scale

0.479

High

533887

GBP1
Guanylate-binding protein 1

1

9

Small-scale

0.479

High

533890

MYH9
Myosin-9

1

2

Small-scale

0.479

High

533893

OX2G
OX-2 membrane glycoprotein

1

2

Small-scale

0.479

High

533895

STAT6
Signal transducer and activator of transcription 6

1

20

Small-scale

0.479

High

533896

STA5A
Signal transducer and activator of transcription 5A

1

20

Small-scale

0.479

High

533901

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

4

High-throughput

0.479

High

533902

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

4

Small-scale

0.479

High

533904

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.479

High

533905

IMA1
Importin subunit alpha-1

1

5

Small-scale

0.479

High

533906

STAT2
Signal transducer and activator of transcription 2

1

20

Small-scale

0.479

High

533907

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

Small-scale

0.479

High

533908

CXCR4
C-X-C chemokine receptor type 4

1

3

Small-scale

0.479

High

533913

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.479

High

533915

TF2B
Transcription initiation factor IIB

1

2

Small-scale

0.479

High

533920

SP2
Transcription factor Sp2

1

1

Small-scale

0.479

High

533922

DYST
Dystonin

1

1

Small-scale

0.479

High

533926

UBE3A
Ubiquitin-protein ligase E3A

1

6

Small-scale

0.479

High

533938

NFIX
Nuclear factor 1 X-type

1

4

Small-scale

0.479

High

533939

SSXT
Protein SSXT

1

5

High-throughput

0.479

High

533941

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

533942

ARID2
AT-rich interactive domain-containing protein 2

1

7

High-throughput

0.479

High

533944

ERAP2
Endoplasmic reticulum aminopeptidase 2

1

2

Small-scale

0.479

High

533945

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

3

High-throughput

0.479

High

533946

PB1
Protein polybromo-1

1

4

High-throughput

0.479

High

533949

ULK2
Serine/threonine-protein kinase ULK2

1

1

High-throughput

0.479

High

533951

IFNL3
Interferon lambda-3

1

7

Small-scale

0.479

High

533952

IL27A
Interleukin-27 subunit alpha

1

3

Small-scale

0.479

High

533953

ARI1B
AT-rich interactive domain-containing protein 1B

1

11

High-throughput

0.479

High

533954

PHF10
PHD finger protein 10

1

7

High-throughput

0.479

High

533955

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

2

High-throughput

0.479

High

533956

DPF1
Zinc finger protein neuro-d4

1

8

High-throughput

0.479

High

533957

REQU
Zinc finger protein ubi-d4

1

8

High-throughput

0.479

High

533961

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

5

High-throughput

0.479

High

533965

ISG20
Interferon-stimulated gene 20 kDa protein

1

1

Small-scale

0.479

High

533966

TRI44
Tripartite motif-containing protein 44

1

12

Small-scale

0.479

High

533967

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

3

High-throughput

0.479

High

533968

CCL19
C-C motif chemokine 19

1

10

Small-scale

0.479

High

533971

FOXP3
Forkhead box protein P3

1

6

Small-scale

0.479

High

533972

SP110
Sp110 nuclear body protein

1

6

Small-scale

0.479

High

533974

BRD7
Bromodomain-containing protein 7

1

16

High-throughput

0.479

High

533977

EVL
Ena/VASP-like protein

1

1

Small-scale

0.479

High

533980

SATB2
DNA-binding protein SATB2

1

2

High-throughput

0.479

High

533863

IL7
Interleukin-7

1

2

Small-scale

0.470

High

533975

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

1

Small-scale

0.470

High

166111

AIM2
Interferon-inducible protein AIM2

1

0

Small-scale

0.458

High

426973

IL6
Interleukin-6

1

0

Small-scale

0.458

High

533866

MMP9
Matrix metalloproteinase-9

1

0

Small-scale

0.458

High

533877

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

533883

CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

1

0

Small-scale

0.458

High

533889

T2FA
General transcription factor IIF subunit 1

1

0

Small-scale

0.458

High

533912

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.458

High

533914

H31
Histone H3.1

1

0

Small-scale

0.458

High

533919

NC2B
Protein Dr1

1

0

Small-scale

0.458

High

533937

NC2A
Dr1-associated corepressor

1

0

Small-scale

0.458

High

533948

MGAP
MAX gene-associated protein

1

0

High-throughput

0.458

High

533963

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

533964

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

0

High-throughput

0.458

High

533970

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

Small-scale

0.458

High

533978

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

Small-scale

0.458

High

533884

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

3

Small-scale

0.445

High

533933

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

14

Small-scale

0.445

High

158929

CXL11
C-X-C motif chemokine 11

1

10

Small-scale

0.437

High

193671

TPSN
Tapasin

1

3

Small-scale

0.437

High

465928

CO1A2
Collagen alpha-2(I) chain

1

1

Small-scale

0.437

High

533880

CATS
Cathepsin S

1

3

Small-scale

0.437

High

533924

TAP2
Antigen peptide transporter 2

1

3

Small-scale

0.437

High

533973

IL21R
Interleukin-21 receptor

1

3

Small-scale

0.437

High

533976

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.269

Low

139174

UPK2
Uroplakin-2

1

0

Small-scale

0.249

Low

353833

I18BP
Interleukin-18-binding protein

1

0

Small-scale

0.249

Low

533878

MIME
Mimecan

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025