Interactor 1: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1
Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.99 | 0.60 | 0.771 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 21737330, 25939870, 25911380, 24098568, 27810922, 27552911, 29431638, 29274253, 23429285, 33052227, 11002417, 33469115, 19060883, 18570872, 34839354, 34853447, 34389694, 35044632, 24147007, 37085671 and 28 others
more... |
| Identification Methods | affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005123 - death receptor binding GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0031264 - death-inducing signaling complex and 12 others more... |
| Homologous interactions | 8 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
