Protein: IMB2
Importin subunit beta-2 (Importin-104) (Karyopherin subunit beta-2) (Karyopherin-104) (Transportin) (TRN)

Gene: IMB2, KAP104
Organism: Saccharomyces cerevisiae S288C
Interactions: 170
UniProt ID: P38217

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005643 - nuclear pore
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005934 - cellular bud tip

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

796081

IMB4
Importin subunit beta-4

3

13

High-throughput

0.830

High

419414

H2A1
Histone H2A.1

2

6

Small-scale

0.778

High

738837

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

12

2

Small-scale

0.761

High

796138

HRP1
Nuclear polyadenylated RNA-binding protein 4

10

7

Small-scale

0.757

High

745716

GSP1
GTP-binding nuclear protein GSP1/CNR1

6

17

Small-scale

0.731

High

419712

H2A2
Histone H2A.2

1

6

High-throughput

0.691

High

796089

T2FB
Transcription initiation factor IIF subunit beta

3

1

Small-scale

0.672

High

755082

GCN1
eIF-2-alpha kinase activator GCN1

3

10

High-throughput

0.662

High

381084

H2B1
Histone H2B.1

1

3

Small-scale

0.647

High

796110

H3
Histone H3

1

13

Small-scale

0.647

High

796113

NU100
Nucleoporin NUP100/NSP100

3

20

Small-scale

0.640

High

796098

NUP57
Nucleoporin NUP57

2

20

Small-scale

0.628

High

796073

ECM29
Proteasome component ECM29

2

12

High-throughput

0.621

High

486148

TBA1
Tubulin alpha-1 chain

2

4

High-throughput

0.618

High

721880

XPO1
Exportin-1

1

10

High-throughput

0.618

High

796122

SXM1
Importin beta SMX1

1

11

High-throughput

0.618

High

796125

IMB1
Importin subunit beta-1

1

13

High-throughput

0.618

High

796070

ENP1
Essential nuclear protein 1

2

0

Small-scale

0.606

High

796099

NUP42
Nucleoporin NUP42

2

20

Small-scale

0.600

High

796117

CLU
Clustered mitochondria protein 1

2

0

High-throughput

0.595

High

392623

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.594

High

796100

NU145
Nucleoporin NUP145

2

20

Small-scale

0.586

High

386682

TBB
Tubulin beta chain

2

3

High-throughput

0.584

High

544623

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.584

High

579274

HSC82
ATP-dependent molecular chaperone HSC82

2

8

High-throughput

0.584

High

592194

VATB
V-type proton ATPase subunit B

2

4

High-throughput

0.584

High

726968

HS104
Heat shock protein 104

2

3

High-throughput

0.584

High

796114

NU116
Nucleoporin NUP116/NSP116

2

20

Small-scale

0.584

High

661619

MPCP
Mitochondrial phosphate carrier protein

2

3

High-throughput

0.565

High

796082

SSB2
Ribosome-associated molecular chaperone SSB2

2

9

High-throughput

0.552

High

416227

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.536

High

427246

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

435921

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.536

High

452732

ADR1
Regulatory protein ADR1

1

3

High-throughput

0.536

High

453557

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.536

High

523729

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.536

High

745938

GSP2
GTP-binding nuclear protein GSP2/CNR2

1

17

High-throughput

0.536

High

750071

MRT4
Ribosome assembly factor MRT4

1

2

High-throughput

0.536

High

796085

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

1

High-throughput

0.536

High

796090

YRB1
Ran-specific GTPase-activating protein 1

1

20

High-throughput

0.536

High

796104

PRS10
26S proteasome subunit RPT4

1

8

High-throughput

0.536

High

796109

YND5
Uncharacterized WD repeat-containing protein YNL035C

1

10

High-throughput

0.536

High

796135

RTN2
Reticulon-like protein 2

1

2

High-throughput

0.536

High

734771

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

2

4

High-throughput

0.521

High

435553

RS9B
Small ribosomal subunit protein uS4B

1

2

High-throughput

0.515

High

788414

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.513

High

794027

KTR3
Probable mannosyltransferase KTR3

1

0

High-throughput

0.513

High

796088

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.513

High

796095

ARC1
tRNA-aminoacylation cofactor ARC1

1

0

High-throughput

0.513

High

796129

SYO1
Synchronized import protein 1

1

0

High-throughput

0.513

High

796136

PAA1
Polyamine N-acetyltransferase 1

1

0

High-throughput

0.513

High

634232

NUP1
Nucleoporin NUP1

1

20

Small-scale

0.508

High

518005

SSBP1
Single-stranded nucleic acid-binding protein

1

6

Small-scale

0.501

High

531711

RL4A
Large ribosomal subunit protein uL4A

1

5

Small-scale

0.501

High

796076

RS14B
Small ribosomal subunit protein uS11B

1

3

Small-scale

0.501

High

796078

RS26A
Small ribosomal subunit protein eS26A

1

2

Small-scale

0.501

High

796107

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

Small-scale

0.501

High

796111

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

7

Small-scale

0.501

High

796116

STE20
Serine/threonine-protein kinase STE20

1

8

Small-scale

0.501

High

796127

TSR2
Pre-rRNA-processing protein TSR2

1

1

Small-scale

0.501

High

796128

ASR1
Alcohol-sensitive RING finger protein 1

1

2

Small-scale

0.501

High

796131

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

1

Small-scale

0.501

High

796132

POM33
Pore membrane protein of 33 kDa

1

2

Small-scale

0.501

High

796134

ARP8
Actin-like protein ARP8

1

2

Small-scale

0.501

High

359003

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.500

High

359467

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.500

High

367740

ENO1
Enolase 1

1

1

High-throughput

0.500

High

403486

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.500

High

405080

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.500

High

416422

HXKA
Hexokinase-1

1

1

High-throughput

0.500

High

420921

PMA1
Plasma membrane ATPase 1

1

3

High-throughput

0.500

High

439319

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.500

High

452892

ATPA
ATP synthase subunit alpha, mitochondrial

1

4

High-throughput

0.500

High

481599

HSP73
Heat shock protein SSA3

1

10

High-throughput

0.500

High

486452

TBA3
Tubulin alpha-3 chain

1

4

High-throughput

0.500

High

701693

URA7
CTP synthase 1

1

1

High-throughput

0.500

High

705762

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

4

High-throughput

0.500

High

709724

BMH1
Protein BMH1

1

2

High-throughput

0.500

High

750827

PRS6B
26S proteasome regulatory subunit 6B homolog

1

3

High-throughput

0.500

High

796077

MET10
Sulfite reductase [NADPH] flavoprotein component

1

2

High-throughput

0.500

High

796119

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.500

High

598321

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.489

High

721100

LCF1
Long-chain-fatty-acid--CoA ligase 1

1

1

High-throughput

0.489

High

734366

OAC1
Mitochondrial oxaloacetate transport protein

1

1

High-throughput

0.489

High

796083

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

4

High-throughput

0.489

High

796120

YHM2
Citrate/oxoglutarate carrier protein

1

1

High-throughput

0.489

High

796137

TECR
Very-long-chain enoyl-CoA reductase

1

1

High-throughput

0.489

High

796112

NUP49
Nucleoporin NUP49/NSP49

1

20

Small-scale

0.481

High

416877

CDC25
Cell division control protein 25

1

0

Small-scale

0.480

High

796115

DIG1
Down-regulator of invasive growth 1

1

0

Small-scale

0.480

High

796118

ACL4
Assembly chaperone of RPL4

1

0

Small-scale

0.480

High

408571

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.479

High

454100

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.479

High

460335

SYV
Valine--tRNA ligase, mitochondrial

1

0

High-throughput

0.479

High

471397

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.479

High

555063

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

572565

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.479

High

590611

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

626708

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

796072

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.479

High

149723

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

435042

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

441869

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

512968

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.479

High

518271

IF4A
ATP-dependent RNA helicase eIF4A

1

5

High-throughput

0.479

High

594339

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

647088

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

674580

RS2
Small ribosomal subunit protein uS5

1

2

Small-scale

0.479

High

706905

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

734947

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

740492

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

6

High-throughput

0.479

High

740898

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

7

Small-scale

0.479

High

747815

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

753329

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

778287

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

796071

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

796092

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

5

High-throughput

0.479

High

796097

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.479

High

796105

HST2
NAD-dependent protein deacetylase HST2

1

9

High-throughput

0.479

High

796108

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

796121

LRS4
Monopolin complex subunit LRS4

1

1

Small-scale

0.479

High

796124

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

796130

SUB2
ATP-dependent RNA helicase SUB2

1

6

High-throughput

0.479

High

796133

RIO1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

514272

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.458

High

796074

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

796079

FIR1
Factor interacting with REF2

1

0

High-throughput

0.458

High

479978

PRTB
Cerevisin

1

1

Small-scale

0.457

High

700095

PRP45
Pre-mRNA-processing protein 45

1

4

High-throughput

0.457

High

456391

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.457

High

575439

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

2

High-throughput

0.457

High

796086

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

5

High-throughput

0.457

High

394488

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

417084

VDAC1
Non-selective voltage-gated ion channel 1

1

2

High-throughput

0.445

High

510427

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.445

High

526509

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

645396

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.445

High

671625

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.445

High

675942

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

741441

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

752179

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

796091

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.445

High

796094

RSSA2
Small ribosomal subunit protein uS2B

1

5

High-throughput

0.445

High

796096

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

585263

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.437

High

737562

ERG1
Squalene epoxidase ERG1

1

2

High-throughput

0.437

High

751691

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

5

High-throughput

0.437

High

796084

ELO3
Fatty acid elongase 3

1

3

High-throughput

0.437

High

684699

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

613851

ERD2
ER lumen protein-retaining receptor

1

2

High-throughput

0.407

High

796080

PIC2
Mitochondrial phosphate carrier protein 2

1

2

High-throughput

0.407

High

796101

PHB2
Prohibitin-2

1

8

High-throughput

0.407

High

796102

ERG25
C-4 methylsterol oxidase ERG25

1

1

High-throughput

0.407

High

796123

PDR15
ATP-dependent permease PDR15

1

1

High-throughput

0.407

High

796087

LCB2
Serine palmitoyltransferase 2

2

0

High-throughput

0.324

High

796093

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

2

0

High-throughput

0.318

High

453054

CBP6
Cytochrome B pre-mRNA-processing protein 6

1

0

High-throughput

0.279

Low

518718

ADH4
Alcohol dehydrogenase 4

1

0

High-throughput

0.279

Low

585550

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.279

Low

613564

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.279

Low

700235

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.279

Low

735822

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.279

Low

743676

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.279

Low

782002

PET10
Protein PET10

1

0

High-throughput

0.279

Low

796075

PSD1
Phosphatidylserine decarboxylase proenzyme 1, mitochondrial

1

0

High-throughput

0.279

Low

796126

TDA5
Uncharacterized oxidoreductase TDA5

1

0

High-throughput

0.269

Low

796106

BSC5
Bypass of stop codon protein 5

1

0

High-throughput

0.265

Low

743759

RML2
Large ribosomal subunit protein uL2m

1

0

Small-scale

0.261

Low

439124

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.261

Low

796103

YG1I
Uncharacterized membrane protein YGR026W

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025