Protein: IMB1
Importin subunit beta-1 (Importin-95) (Karyopherin subunit beta-1) (Karyopherin-95)

Gene: IMB1, KAP95
Organism: Saccharomyces cerevisiae S288C
Interactions: 216
UniProt ID: Q06142

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005643 - nuclear pore
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1039045

IMA1
Importin subunit alpha

22

20

Small-scale

0.991

High

745880

GSP1
GTP-binding nuclear protein GSP1/CNR1

19

18

Small-scale

0.987

High

734733

IMB3
Importin subunit beta-3

4

13

Small-scale

0.892

High

419509

H2A1
Histone H2A.1

3

5

Small-scale

0.840

High

634284

NUP1
Nucleoporin NUP1

25

20

Small-scale

0.768

High

813657

NUP60
Nucleoporin NUP60

14

2

Small-scale

0.762

High

738510

NUP2
Nucleoporin NUP2

14

20

Small-scale

0.761

High

1037961

NU100
Nucleoporin NUP100/NSP100

13

20

Small-scale

0.760

High

1037990

NU116
Nucleoporin NUP116/NSP116

11

20

Small-scale

0.756

High

577351

NSP1
Nucleoporin NSP1

7

20

Small-scale

0.744

High

1038105

ULP1
Ubiquitin-like-specific protease 1

7

6

Small-scale

0.743

High

1053880

RRP6
Exosome complex exonuclease RRP6

7

2

Small-scale

0.739

High

886183

NUP42
Nucleoporin NUP42

6

20

Small-scale

0.727

High

1053876

NCBP2
Nuclear cap-binding protein subunit 2

6

4

High-throughput

0.727

High

1035273

NUP49
Nucleoporin NUP49/NSP49

5

20

Small-scale

0.713

High

647840

RFA1
Replication factor A protein 1

5

7

Small-scale

0.712

High

877987

NUP57
Nucleoporin NUP57

5

20

Small-scale

0.707

High

825181

NU159
Nucleoporin NUP159

4

20

Small-scale

0.686

High

886208

NU145
Nucleoporin NUP145

4

20

Small-scale

0.683

High

757540

NCBP1
Nuclear cap-binding protein complex subunit 1

4

1

High-throughput

0.678

High

1050646

NUP59
Nucleoporin ASM4

3

4

Small-scale

0.670

High

1053866

IMB1
Importin subunit beta-1

1

11

High-throughput

0.665

High

646541

RAD53
Serine/threonine-protein kinase RAD53

3

3

High-throughput

0.657

High

1044095

NUP53
Nucleoporin NUP53

3

4

Small-scale

0.651

High

580093

HSC82
ATP-dependent molecular chaperone HSC82

3

8

High-throughput

0.633

High

740014

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

2

2

Small-scale

0.628

High

796852

SIF2
SIR4-interacting protein SIF2

2

5

High-throughput

0.621

High

893435

ZDS1
Protein ZDS1

2

2

High-throughput

0.621

High

381268

H2B1
Histone H2B.1

1

6

Small-scale

0.618

High

722270

XPO1
Exportin-1

1

9

High-throughput

0.618

High

779351

CENPA
Histone H3-like centromeric protein CSE4

1

14

High-throughput

0.618

High

796125

IMB2
Importin subunit beta-2

1

13

High-throughput

0.618

High

850578

RSC8
Chromatin structure-remodeling complex protein RSC8

2

3

High-throughput

0.612

High

919001

PESC
Pescadillo homolog

2

1

High-throughput

0.612

High

921196

THO2
THO complex subunit 2

2

1

High-throughput

0.612

High

817959

IMB4
Importin subunit beta-4

2

12

High-throughput

0.611

High

546340

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.601

High

781804

SET3
SET domain-containing protein 3

2

2

High-throughput

0.601

High

1053890

CAF1A
Chromatin assembly factor 1 subunit A

2

1

High-throughput

0.601

High

561534

TBP
TATA-box-binding protein

2

1

Small-scale

0.595

High

914998

NUP84
Nucleoporin NUP84

2

2

Small-scale

0.595

High

924589

EAF7
Chromatin modification-related protein EAF7

2

1

Small-scale

0.588

High

824795

MLP2
Protein MLP2

2

8

Small-scale

0.584

High

1053896

MEX67
mRNA export factor MEX67

2

6

High-throughput

0.584

High

626539

AP1
AP-1-like transcription factor YAP1

2

2

Small-scale

0.576

High

1044062

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

2

0

High-throughput

0.576

High

525200

HSP71
Heat shock protein SSA1

2

9

Small-scale

0.571

High

755177

GCN1
eIF-2-alpha kinase activator GCN1

2

10

High-throughput

0.571

High

817789

RT105
Regulator of Ty1 transposition protein 105

2

0

Small-scale

0.569

High

836902

MPG1
Mannose-1-phosphate guanyltransferase

2

2

High-throughput

0.562

High

916520

MIG2
Regulatory protein MIG2

1

20

Small-scale

0.561

High

527718

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

819841

SSB2
Ribosome-associated molecular chaperone SSB2

2

8

High-throughput

0.552

High

779194

NDK
Nucleoside diphosphate kinase

1

2

High-throughput

0.541

High

416569

HXKB
Hexokinase-2

1

0

Small-scale

0.537

High

1053872

RRP44
Exosome complex exonuclease DIS3

1

0

Small-scale

0.537

High

453798

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.536

High

531405

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

621408

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.536

High

742435

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.536

High

790520

CCL1
Cyclin CCL1

1

3

High-throughput

0.536

High

843149

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

1

High-throughput

0.536

High

858071

RSSA2
Small ribosomal subunit protein uS2B

1

3

High-throughput

0.536

High

1053875

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

3

High-throughput

0.536

High

479699

F16P
Fructose-1,6-bisphosphatase

1

0

High-throughput

0.518

High

753041

SPC29
Spindle pole component 29

1

0

High-throughput

0.518

High

444798

SIR2
NAD-dependent histone deacetylase SIR2

1

7

Small-scale

0.515

High

671141

SIS1
Protein SIS1

1

2

High-throughput

0.515

High

735465

AAR2
A1 cistron-splicing factor AAR2

1

3

High-throughput

0.515

High

805139

YNG2
Chromatin modification-related protein YNG2

1

2

High-throughput

0.515

High

808666

AURK
Aurora kinase

1

3

High-throughput

0.515

High

1030546

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

High-throughput

0.515

High

1051563

RT103
Regulator of Ty1 transposition protein 103

1

1

High-throughput

0.515

High

1053873

SGT1
Protein SGT1

1

1

High-throughput

0.515

High

1053888

NOP56
Nucleolar protein 56

1

2

High-throughput

0.515

High

617818

SNF6
Transcription regulatory protein SNF6

1

0

High-throughput

0.513

High

820507

PIG2
GSY2-interacting protein PIG2

1

0

High-throughput

0.513

High

923768

POP3
Ribonucleases P/MRP protein subunit POP3

1

0

High-throughput

0.513

High

1053883

RLM1
Transcription factor RLM1

1

0

High-throughput

0.513

High

756664

NIC96
Nucleoporin NIC96

1

4

Small-scale

0.501

High

812020

RS14B
Small ribosomal subunit protein uS11B

1

3

Small-scale

0.501

High

916429

SEH1
Nucleoporin SEH1

1

7

Small-scale

0.501

High

1053868

ASR1
Alcohol-sensitive RING finger protein 1

1

2

Small-scale

0.501

High

1053881

POM33
Pore membrane protein of 33 kDa

1

3

Small-scale

0.501

High

1053884

GLE1
mRNA export factor GLE1

1

2

Small-scale

0.501

High

432366

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.493

High

511858

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.493

High

624943

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

High-throughput

0.493

High

865421

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.493

High

887763

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.493

High

916926

TAN1
tRNA acetyltransferase TAN1

1

0

High-throughput

0.493

High

920921

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

High-throughput

0.493

High

1052781

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.493

High

738563

NDC1
Nucleoporin NDC1

1

0

Small-scale

0.480

High

1053886

POM34
Nucleoporin POM34

1

0

Small-scale

0.480

High

393357

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.479

High

434444

RL15A
Large ribosomal subunit protein eL15A

1

2

Small-scale

0.479

High

509725

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

10

High-throughput

0.479

High

509925

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

7

High-throughput

0.479

High

514064

RL18B
Large ribosomal subunit protein eL18B

1

2

Small-scale

0.479

High

518392

IF4A
ATP-dependent RNA helicase eIF4A

1

4

High-throughput

0.479

High

531896

RL4A
Large ribosomal subunit protein uL4A

1

4

Small-scale

0.479

High

536171

ARF1
ADP-ribosylation factor 1

1

1

High-throughput

0.479

High

548727

RNA1
Ran GTPase-activating protein 1

1

5

High-throughput

0.479

High

632439

CG12
G1/S-specific cyclin CLN2

1

2

Small-scale

0.479

High

639070

VPS1
Vacuolar protein sorting-associated protein 1

1

3

High-throughput

0.479

High

642473

MCK1
Protein kinase MCK1

1

6

High-throughput

0.479

High

689141

RL16A
Large ribosomal subunit protein uL13A

1

1

Small-scale

0.479

High

689285

RL16B
Large ribosomal subunit protein uL13B

1

1

Small-scale

0.479

High

708226

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

727319

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

735167

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

738929

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

748050

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

779513

YKT6
Synaptobrevin homolog YKT6

1

3

High-throughput

0.479

High

782226

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

1

High-throughput

0.479

High

795225

NU170
Nucleoporin NUP170

1

4

Small-scale

0.479

High

795544

ATG8
Autophagy-related protein 8

1

11

High-throughput

0.479

High

803815

BRL1
Nucleus export protein BRL1

1

1

Small-scale

0.479

High

805311

GGA2
ADP-ribosylation factor-binding protein GGA2

1

1

High-throughput

0.479

High

805577

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

5

Small-scale

0.479

High

812119

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

812672

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

816605

GEA2
ARF guanine-nucleotide exchange factor 2

1

3

High-throughput

0.479

High

825120

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

1

High-throughput

0.479

High

826848

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

836687

YRB1
Ran-specific GTPase-activating protein 1

1

20

High-throughput

0.479

High

885092

RL4B
Large ribosomal subunit protein uL4B

1

4

Small-scale

0.479

High

893299

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

High-throughput

0.479

High

932182

RL15B
Large ribosomal subunit protein eL15B

1

2

Small-scale

0.479

High

1036926

MLP1
Protein MLP1

1

8

High-throughput

0.479

High

1042237

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

1044463

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.479

High

1045090

SXM1
Importin beta SMX1

1

11

High-throughput

0.479

High

1053867

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

1053869

BRE1
E3 ubiquitin-protein ligase BRE1

1

4

Small-scale

0.479

High

1053874

ESA1
Histone acetyltransferase ESA1

1

4

Small-scale

0.479

High

1053879

ELG1
Telomere length regulation protein ELG1

1

1

Small-scale

0.479

High

1053882

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

1053887

OSH2
Oxysterol-binding protein homolog 2

1

1

High-throughput

0.479

High

1053894

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.479

High

1053891

NOP58
Nucleolar protein 58

1

2

High-throughput

0.470

High

515385

RS32B
Small ribosomal subunit protein eS32B

1

0

Small-scale

0.458

High

619444

MED14
Mediator of RNA polymerase II transcription subunit 14

1

0

High-throughput

0.458

High

743557

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

751489

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

764009

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

764158

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

795807

SHE1
Mitotic spindle-associated protein SHE1

1

0

High-throughput

0.458

High

817164

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

0

High-throughput

0.458

High

858359

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.458

High

864456

TIM54
Mitochondrial import inner membrane translocase subunit TIM54

1

0

High-throughput

0.458

High

865391

RAV1
Regulator of V-ATPase in vacuolar membrane protein 1

1

0

High-throughput

0.458

High

925062

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

1025655

NAM8
Protein NAM8

1

0

High-throughput

0.458

High

1027373

REG1
Resistance to glucose repression protein 1

1

0

Small-scale

0.458

High

1038754

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

1045005

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.458

High

1051186

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

1053895

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.458

High

359356

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

High-throughput

0.445

High

386867

TBB
Tubulin beta chain

1

2

High-throughput

0.445

High

394920

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

694644

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.445

High

736733

ASF1
Histone chaperone ASF1

1

3

High-throughput

0.445

High

739468

ZUO1
Zuotin

1

3

High-throughput

0.445

High

752753

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

796184

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.445

High

864964

NOP9
Nucleolar protein 9

1

1

High-throughput

0.445

High

922670

HST3
NAD-dependent histone deacetylase HST3

1

7

High-throughput

0.445

High

1025784

RAD25
General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2

1

2

High-throughput

0.445

High

1048414

RCO1
Transcriptional regulatory protein RCO1

1

13

High-throughput

0.445

High

1053892

RKM4
Ribosomal lysine N-methyltransferase 4

1

2

High-throughput

0.445

High

1053893

SET6
Potential protein lysine methyltransferase SET6

1

1

High-throughput

0.445

High

578251

TAL1
Transaldolase

1

0

High-throughput

0.438

High

528641

CP51
Lanosterol 14-alpha demethylase CYP51

1

1

High-throughput

0.437

High

646270

SEC22
Protein transport protein SEC22

1

3

High-throughput

0.437

High

682386

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

688769

RFA2
Replication factor A protein 2

1

6

Small-scale

0.437

High

734788

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

4

High-throughput

0.437

High

735361

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

1

High-throughput

0.437

High

737590

ERG1
Squalene epoxidase ERG1

1

2

High-throughput

0.437

High

751717

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

5

High-throughput

0.437

High

796246

CST26
2-acyl-1-lysophosphatidylinositol acyltransferase

1

1

High-throughput

0.437

High

822344

ELO3
Fatty acid elongase 3

1

3

High-throughput

0.437

High

877911

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

1038556

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

High-throughput

0.437

High

1053871

COQ10
Coenzyme Q-binding protein COQ10, mitochondrial

1

1

High-throughput

0.437

High

1053877

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

1053885

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

561094

PCY1
Choline-phosphate cytidylyltransferase

1

0

High-throughput

0.426

High

811404

CAJ1
Protein CAJ1

1

0

High-throughput

0.426

High

813856

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.426

High

1025178

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

1045030

YHP1
Homeobox protein YHP1

1

0

High-throughput

0.426

High

703850

LAC1
Ceramide synthase LAC1

1

5

High-throughput

0.407

High

802497

LAG1
Ceramide synthase LAG1

1

5

High-throughput

0.407

High

808999

HXT7
High-affinity hexose transporter HXT7

1

2

High-throughput

0.407

High

811169

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.407

High

864241

GWT1
GPI-anchored wall transfer protein 1

1

1

High-throughput

0.407

High

1045147

PDR15
ATP-dependent permease PDR15

1

2

High-throughput

0.407

High

1053889

AIR2
Protein AIR2

1

1

High-throughput

0.407

High

1047341

SSL1
General transcription and DNA repair factor IIH subunit SSL1

2

0

High-throughput

0.307

High

533496

TIR1
Cold shock-induced protein TIR1

2

0

Small-scale

0.305

High

793845

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.282

High

688824

RFA3
Replication factor A protein 3

1

0

High-throughput

0.279

Low

1053870

NOP6
Nucleolar protein 6

1

0

High-throughput

0.279

Low

438492

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.269

Low

805092

RPF1
Ribosome production factor 1

1

0

Small-scale

0.261

Low

677087

MGR1
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1

1

0

High-throughput

0.249

Low

808311

RRP8
25S rRNA

1

0

High-throughput

0.249

Low

823172

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.249

Low

922985

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.249

Low

923046

YN8O
Uncharacterized protein YNR040W

1

0

High-throughput

0.249

Low

1053878

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025