HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	29084956, 16682412
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Hist_deacetyl~MBD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0010629 - negative regulation of gene expression GO:1990841 - promoter-specific chromatin binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 1291
+	Hs
		1065669 HDAC2_HUMAN (1-478): 0: 666: 85.92		SETB1_HUMAN (1-1291): 0: 1373: 100.00
+	Hs
		1038721 HDAC1_HUMAN (1-482): 0: 668: 100.00		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Hs
		1270450 HDAC2_HUMAN (1-478): 0: 666: 85.92		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Hs
		203679 HDAC1_HUMAN (1-482): 0: 668: 100.00		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Mm
		140205 HDAC1_MOUSE (1-482): 0: 672: 99.38		SUV91_MOUSE (658-970): 1.78e-68: 238: 22.39
+	Hs
		203750 HDAC2_HUMAN (1-478): 0: 666: 85.92		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		1038631 HDAC1_HUMAN (1-482): 0: 668: 100.00		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Hs
		1270381 HDAC2_HUMAN (1-478): 0: 666: 85.92		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Mm
		222461 HDAC2_MOUSE (1-478): 0: 664: 85.71		SUV91_MOUSE (658-970): 1.78e-68: 238: 22.39
+	Mm
		140274 HDAC1_MOUSE (1-482): 0: 672: 99.38		EZH2_MOUSE (1026-1272): 1.15e-48: 188: 13.13
+	Hs
		1038412 HDAC1_HUMAN (1-482): 0: 668: 100.00		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Hs
		1080187 HDAC2_HUMAN (1-478): 0: 666: 85.92		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Dm
		115789 HDAC1_DROME (6-477): 0: 658: 77.33		M9PGH7_DROME (1001-1287): 2.2e-49: 195: 16.67
+	Mm
		936404 HDAC2_MOUSE (1-478): 0: 664: 85.71		Q6AXH7_MOUSE (1026-1272): 1.64e-48: 188: 13.13
+	Hs
		177134 HDAC3_HUMAN (9-434): 0: 574: 57.94		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Mm
		222457 HDAC3_MOUSE (9-434): 0: 574: 58.18		SUV91_MOUSE (658-970): 1.78e-68: 238: 22.39
+	Hs
		177306 HDAC3_HUMAN (9-434): 0: 574: 57.94		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Hs
		1343545 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		KMT5A_HUMAN (811-916): 4.51e-15: 80.7: 17.39